Explanipedia

Evaluation of antigen and antibody assays for surveillance of Lassa virus in peri-domestic rodents in southeastern Sierra Leone: a cross-sectional study Open

Allison R. Smither, James Koninga, Franklyn Kanneh, Momoh Foday, Matthew L. Boisen , et al. · 2025

Summary: Background: Lassa fever, caused by Lassa mammarenavirus (LASV), is a rodent-borne disease endemic to west Africa. Zoonotic surveillance of LASV provides epidemiological insights into its potential presence. We aimed to assess LASV…

Continuous vital sign monitoring of acute Lassa fever using wearable biosensor devices in West Africa Open

Brady Page, Raphaëlle Klitting, Matthias Pauthner, Steven R. Steinhubl, Stephan Wegerich , et al. · 2025

Continuous vital sign monitoring of individuals with acute Lassa fever using wearable biosensor devices Open

Brady Page, Raphaëlle Klitting, Matthias Pauthner, Steven R. Steinhubl, Stephan Wegerich , et al. · 2024

Background Lassa fever is a fulminant viral illness associated with high in-hospital mortality. This disease constitutes a serious public health concern in West Africa, in particular Nigeria and the Mano River Union region (Guinea, Liberia…

Priming antibody responses to the fusion peptide in rhesus macaques Open

Christopher A. Cottrell, Payal Pratap, Kimberly M. Cirelli, Diane G. Carnathan, Chiamaka A. Enemuo , et al. · 2024

Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever Open

Dylan Kotliar, Siddharth S. Raju, Shervin Tabrizi, Ikponmwosa Odia, Augustine Goba , et al. · 2024

Focusing antibody responses to the fusion peptide in rhesus macaques Open

Christopher A. Cottrell, Payal Pratap, Kimberly M. Cirelli, Diane G. Carnathan, Chiamaka A. Enemuo , et al. · 2023

Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the developm…

Novel Tools for Lassa Virus Surveillance in Peri-domestic Rodents Open

Allison R. Smither, James Koninga, Franklyn Kanneh, Momoh Foday, Matthew L. Boisen , et al. · 2023

Background Lassa fever (LF) is a rodent-borne disease endemic to West Africa. In the absence of licensed therapeutics or vaccines, rodent exclusion from living spaces remains the primary method of preventing LF. Zoonotic surveillance of La…

Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades Open

Raphaëlle Klitting, Liana E. Kafetzopoulou, Wim Thiery, Gytis Dudas, Sophie Gryseels , et al. · 2022

Predicting the evolution of Lassa Virus endemic area and population at risk over the next decades Open

Raphaëlle Klitting, Liana E. Kafetzopoulou, Wim Thiery, Gytis Dudas, Sophie Gryseels , et al. · 2021

Lassa fever is listed among the diseases that pose the greatest risks to public health by the World Health Organization. This severe viral hemorrhagic fever is caused by Lassa virus, a zoonotic pathogen that repeatedly spills over to human…

A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus Open

Bronwyn M. Gunn, Richard Lu, Matthew D. Slein, Philipp A. Ilinykh, Kai Huang , et al. · 2021

Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo Open

Eddy Kinganda-Lusamaki, Allison Black, Daniel Bamuleka Mukadi, James Hadfield, Placide Mbala‐Kingebeni , et al. · 2021

Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease Open

Placide Mbala‐Kingebeni, Catherine Pratt, Mbusa Mutafali-Ruffin, Matthias Pauthner, Faustin N. Bile , et al. · 2021

During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV…

Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome Open

Maurício A. Martins, Lucas Gonzalez-Nieto, Michael J. Ricciardi, Varian K. Bailey, Christine M. Dang , et al. · 2020

Our results are relevant to HIV vaccine development efforts because they suggest that increasing the number of booster immunizations or delivering additional viral antigens may not necessarily improve vaccine efficacy against immunodeficie…

Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Open

Fangzhu Zhao, Collin Joyce, Alison Burns, Bartek Nogal, Christopher A. Cottrell , et al. · 2020

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers Open

Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru , et al. · 2020

T follicular helper (T_FH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. T…

HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Open

Bartek Nogal, Laura E. McCoy, Marit J. van Gils, Christopher A. Cottrell, James E. Voss , et al. · 2020

Strain-specific autologous neutralizing antibodies may compete with N332 supersite targeting broadly neutralizing precursors.

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies Open

Núria Pedreño-López, Christine M. Dang, Brandon C. Rosen, Michael J. Ricciardi, Varian K. Bailey , et al. · 2020

Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits Open

Yuhe R. Yang, Laura E. McCoy, Marit J. van Gils, Raiees Andrabi, Hannah L. Turner , et al. · 2020

A glycan hole is one of the most dominant autologous neutralizing epitopes targeted on BG505 and B41 SOSIP trimer-immunized rabbits. Our high-resolution cryo-electron microscopy (cryoEM) studies of B41 in complex with a B41-specific antibo…

A Fc-Engineering Approach to Define Functional Humoral Correlates of Immunity Against Ebola Virus Open

Bronwyn M. Gunn, Richard Lu, Matthew D. Slein, Philipp A. Ilinykh, Kai Huang , et al. · 2020

Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Open

Fangzhu Zhao, Collin Joyce, Alison Burns, Bartek Nogal, Alejandra Ramos , et al. · 2020

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance Open

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, Jacob T. Martin, Oscar L. Rodriguez , et al. · 2020

Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Open

Fangzhu Zhao, Collin Joyce, Alison Burns, Bartek Nogal, Alejandra Ramos , et al. · 2020

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite Open

Bartek Nogal, Laura E. McCoy, Marit J. van Gils, Christopher A. Cottrell, James E. Voss , et al. · 2019

To date, immunization studies of rabbits with the BG505 SOSIP.664 HIV envelope glycoprotein trimers have revealed the 241/289 glycan hole as the dominant neutralizing antibody epitope. Here, we isolated monoclonal antibodies from a rabbit …

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened Open

Yuhe R. Yang, Laura E. McCoy, Marit J. van Gils, Raiees Andrabi, Hannah L. Turner , et al. · 2019

Extensive studies with subtype A BG505-derived HIV envelope glycoprotein (Env) SOSIP immunogens have revealed that the dominant autologous neutralizing site in rabbits is located in an exposed region of the heavily glycosylated trimer that…

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge Open

Amarendra Pegu, Bhavesh Borate, Yunda Huang, Matthias Pauthner, Ann J. Hessell , et al. · 2019

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance Open

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, Jacob T. Martin, Oscar L. Rodriguez , et al. · 2019

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template Open

Raiees Andrabi, Jesper Pallesen, Joel D. Allen, Ge Song, Jinsong Zhang , et al. · 2019

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers Open

Matthias Pauthner, Joseph P. Nkolola, Colin Havenar‐Daughton, Ben Murrell, Samantha Reiss , et al. · 2018

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template Open

Raiees Andrabi, Jesper Pallesen, Joel D. Allen, Ge Song, Jinsong Zhang , et al. · 2018

Summary Epitope-targeted HIV vaccine design seeks to focus antibody responses to broadly neutralizing antibody (bnAb) sites by sequential immunization. Chimpanzee SIV Envelope (Env) shares a single bnAb site, the V2-apex, with HIV, suggest…

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates Open

Matthias Pauthner, Joseph P. Nkolola, Colin Havenar‐Daughton, Ben Murrell, Samantha Reiss , et al. · 2018

SUMMARY Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (Tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge. However, conditions for nAb-mediated protection follo…

Matthias Pauthner YOU? Author Swipe