Matthias Pawlowski
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View article: The examination of the spatial and contextual disparities of determinant factors of adult obesity among communities in Chicago
The examination of the spatial and contextual disparities of determinant factors of adult obesity among communities in Chicago Open
The issue of adult obesity has multiple complexes contributing factors and is becoming a significant public health concern worldwide, including in the neighborhoods of Chicago. This study utilized data on nineteen demographic, environmenta…
View article: Cytoskeletal disruption-induced calcium dysregulation drives cell death in anti-IgLON5 disease
Cytoskeletal disruption-induced calcium dysregulation drives cell death in anti-IgLON5 disease Open
View article: CSF and blood signatures support classification of limbic encephalitis subtypes
CSF and blood signatures support classification of limbic encephalitis subtypes Open
Autoimmune limbic encephalitis (ALE) represents a heterogeneous disease associated with antibodies targeting extracellular (ALEextra) epitopes, intracellular (ALEintra) epitopes, anti-glutamic acid decarboxylase65 ALE…
View article: Forward programming human pluripotent stem cells into microglia
Forward programming human pluripotent stem cells into microglia Open
Microglia play vital roles in embryonic and post-natal development, homeostasis, and pathogen defence in the central nervous system. Human induced pluripotent stem cell (hiPSC)-based methods have emerged as an important source for the stud…
View article: Quantitative Analysis of Retinal Perfusion in Patients with Frontotemporal Dementia Using Optical Coherence Tomography Angiography
Quantitative Analysis of Retinal Perfusion in Patients with Frontotemporal Dementia Using Optical Coherence Tomography Angiography Open
Background: Optical coherence tomography angiography (OCT-A) provides detailed visualization of the perfusion of the vascular network of the eye. While in other forms of dementia, such as Alzheimer’s disease and mild cognitive impairment, …
View article: NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores
NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores Open
View article: MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD
MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD Open
View article: Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease
Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease Open
Microglia, the resident immune cells of the central nervous system (CNS), are derived from yolk-sac macrophages that populate the developing CNS during early embryonic development. Once established, the microglia population is self-maintai…
View article: Patients with a relapsing course of steroid‐responsive encephalopathy associated with autoimmune thyroiditis exhibit persistent intrathecal CD4+ T‐cell activation
Patients with a relapsing course of steroid‐responsive encephalopathy associated with autoimmune thyroiditis exhibit persistent intrathecal CD4+ T‐cell activation Open
Background and purpose Steroid‐responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare condition defined by encephalopathy with acute or subacute onset, the presence of serum anti‐thyroid antibodies, and reasonab…
View article: Autoimmunity complicating SARS-CoV-2 infection in selective IgA-deficiency
Autoimmunity complicating SARS-CoV-2 infection in selective IgA-deficiency Open
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 can result in severe disease and become critically challenging to hospitals via high demand for intensive care and mechanical ventilation. Guillain-Barré syndrome (GBS) and its varia…
View article: Früh beginnende Demenzen
Früh beginnende Demenzen Open
View article: Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids Open
The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic strictures, is restricted by the lack of biliary tissue from healthy donors suitable for surgical reconstruction. Here we report a new method for the is…
View article: Comorbidities in dementia: state of knowledge
Comorbidities in dementia: state of knowledge Open
View article: Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration
Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration Open
Microglia play an essential role for central nervous system (CNS) development and homeostasis and have been implicated in the onset, progression, and clearance of numerous diseases affecting the CNS. Previous in vitro research on human mic…
View article: Substance P Saliva Reduction Predicts Pharyngeal Dysphagia in Parkinson's Disease
Substance P Saliva Reduction Predicts Pharyngeal Dysphagia in Parkinson's Disease Open
Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotr…
View article: Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease
Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease Open
Background: Parkinson's disease (PD) is a common neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood. Methods: In this study, we performed comprehensive immune…
View article: Distinguishing neurocognitive deficits in adult patients with NP-C from early onset Alzheimer’s dementia
Distinguishing neurocognitive deficits in adult patients with NP-C from early onset Alzheimer’s dementia Open
A combination of detailed yet easy-to-apply neurocognitive tests assessing verbal memory, executive functions and verbal fluency may help distinguish NP-C cases from those with primary dementia due to eAD.
View article: Conditional Manipulation of Gene Function in Human Cells with Optimized Inducible shRNA
Conditional Manipulation of Gene Function in Human Cells with Optimized Inducible shRNA Open
The difficulties involved in conditionally perturbing complex gene expression networks represent major challenges toward defining the mechanisms controlling human development, physiology, and disease. We developed an OPTimized inducible Kn…
View article: Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside
Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside Open
Alzheimer’s disease is the most common cause of dementia. Over the last three decades, research has advanced dramatically and provided a detailed understanding of the molecular events underlying the pathogenesis of Alzheimer’s disease. In …
View article: Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids Open
View article: Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes
Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes Open
View article: Replacement of the murine common bile duct with a bioengineered conduit incorporating primary human cholangiocyte organoids
Replacement of the murine common bile duct with a bioengineered conduit incorporating primary human cholangiocyte organoids Open
View article: Effectiveness of immunotherapy in children depends on place of living – A pilot study
Effectiveness of immunotherapy in children depends on place of living – A pilot study Open
The current analysis of the better AIT effectiveness in the farm population has shown the protective influence of environmental exposures on asthma and allergic rhinitis in our children.
View article: Optimized inducible shRNA and CRISPR/Cas9 platforms for <i>in vitro</i> studies of human development using hPSCs
Optimized inducible shRNA and CRISPR/Cas9 platforms for <i>in vitro</i> studies of human development using hPSCs Open
Inducible loss of gene function experiments are necessary to uncover mechanisms underlying development, physiology and disease. However, current methods are complex, lack robustness and do not work in multiple cell types. Here we address t…