Matthias S. Leisegang
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View article: Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents
Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents Open
View article: Mutant p53-specific CD8TCR-therapy combined with a CD4TCR prevents relapse of cancer and outgrowth of micrometastases
Mutant p53-specific CD8TCR-therapy combined with a CD4TCR prevents relapse of cancer and outgrowth of micrometastases Open
Relapse remains challenging in the treatment of metastatic cancers. More than 50% of human cancers harbor mutant p53 (mp53) as a cancer-specific target. We present the spontaneously metastasizing tumor model Ag104A to advance mp53-specific…
View article: The relevance of RNA–DNA interactions as regulators of physiological functions
The relevance of RNA–DNA interactions as regulators of physiological functions Open
View article: GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data
GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data Open
Extraction of meaningful biological insight from gene expression profiling often focuses on the identification of statistically enriched terms or pathways. These methods typically use gene sets as input data, and subsequently return overre…
View article: Revealing microRNA regulation in single cells
Revealing microRNA regulation in single cells Open
MicroRNAs (miRNAs) are key regulators of gene expression and control cellular functions in physiological and pathophysiological states. miRNAs play important roles in disease, stress, and development, and are now being investigated for the…
View article: Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers
Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers Open
The coordination of chromatin remodeling is essential for DNA accessibility and gene expression control. The highly conserved and ubiquitously expressed SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex plays a central …
View article: Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents
Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents Open
Background The regulatory network that coordinates gene expression ultimately determines the phenotype of an organism. Micro-RNAs (miRNAs) are post-transcriptional regulators involved in key biological processes. Lineage-specific losses of…
View article: The endocannabinoid anandamide mediates anti‐inflammatory effects through activation of NR4A nuclear receptors
The endocannabinoid anandamide mediates anti‐inflammatory effects through activation of NR4A nuclear receptors Open
Background and purpose Endocannabinoids are lipid mediators, which elicit complex biological effects that extend beyond the central nervous system. Tissue concentrations of endocannabinoids increase in atherosclerosis, and for the endocann…
View article: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions
RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions Open
Monocytes, the circulating macrophage precursors, contribute to diseases like atherosclerosis and asthma. Long non-coding RNAs (lncRNAs) have been shown to modulate the phenotype and inflammatory capacity of monocytes. We previously discov…
View article: LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses
LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses Open
The functional role of long noncoding RNAs in the endothelium is highly diverse. Among their many functions, regulation of transcription factor activity and abundance is one of the most relevant. This review summarizes the recent progress …
View article: The transaminase-ω-amidase pathway is a redox switch in glutamine metabolism that generates α-ketoglutarate
The transaminase-ω-amidase pathway is a redox switch in glutamine metabolism that generates α-ketoglutarate Open
Summary Oxidative stress is caused by short-lived molecules and metabolic changes belong to the fastest cellular responses. Here we studied how the endothelial cell metabolome reacts to acute oxidative challenges (menadione or H 2 O 2 ) to…
View article: GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data
GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data Open
Extraction of meaningful biological insight from gene expression profiling often focuses on the identification of statistically enriched terms or pathways. These methods typically use gene sets as input data, and subsequently return overre…
View article: RNA-DNA triplexes: molecular mechanisms and functional relevance
RNA-DNA triplexes: molecular mechanisms and functional relevance Open
Interactions of RNA with DNA are principles of gene expression control that have recently gained considerable attention. Among RNA-DNA interactions are R-loops and RNA-DNA hybrid G-quadruplexes, as well as RNA-DNA triplexes. It is proposed…
View article: Long non-coding RNAs direct the SWI/SNF complex to cell-specific enhancers
Long non-coding RNAs direct the SWI/SNF complex to cell-specific enhancers Open
The coordination of chromatin remodeling is essential for DNA accessibility and gene expression control 1 . The highly conserved and ubiquitously expressed SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex plays a centr…
View article: Biophysical Investigation of RNA ⋅ DNA : DNA Triple Helix and RNA : DNA Heteroduplex Formation by the lncRNAs <i>MEG3</i> and <i>Fendrr</i>
Biophysical Investigation of RNA ⋅ DNA : DNA Triple Helix and RNA : DNA Heteroduplex Formation by the lncRNAs <i>MEG3</i> and <i>Fendrr</i> Open
Long non‐coding RNAs (lncRNAs) are important regulators of gene expression and can associate with DNA as RNA : DNA heteroduplexes or RNA ⋅ DNA : DNA triple helix structures. Here, we review in vitro biochemical and biophysical experiments …
View article: The aging-induced long non-coding RNA<i>MIRIAL</i>controls endothelial cell and mitochondrial function
The aging-induced long non-coding RNA<i>MIRIAL</i>controls endothelial cell and mitochondrial function Open
Aims Vascular aging is characterized by the progressive deterioration of endothelial function. Long non-coding RNAs (lncRNAs) are critical regulators of gene expression and protein function. However, their involvement in aging-related dysr…
View article: <scp>ADPGK‐AS1</scp> long noncoding <scp>RNA</scp> switches macrophage metabolic and phenotypic state to promote lung cancer growth
<span>ADPGK‐AS1</span> long noncoding <span>RNA</span> switches macrophage metabolic and phenotypic state to promote lung cancer growth Open
View article: Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4
Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4 Open
Circular RNAs are generated by backsplicing and control cellular signaling and phenotypes. Pericytes stabilize capillary structures and play important roles in the formation and maintenance of blood vessels. Here, we characterize hypoxia-r…
View article: Adhesion of human pathogenic bacteria to endothelial cells is facilitated by fibronectin interaction
Adhesion of human pathogenic bacteria to endothelial cells is facilitated by fibronectin interaction Open
View article: ncOrtho: efficient and reliable identification of miRNA orthologs
ncOrtho: efficient and reliable identification of miRNA orthologs Open
MicroRNAs (miRNAs) are post-transcriptional regulators that finetune gene expression via translational repression or degradation of their target mRNAs. Despite their functional relevance, frameworks for the scalable and accurate detection …
View article: Supplementary Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors
Supplementary Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors Open
Supplementary information containing Supplementary Methods, Supplementary References, Supplementary Figure 1, and Supplementary Figure 2.
View article: Supplementary Table S1 from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors
Supplementary Table S1 from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors Open
Supplementary Table S1
View article: Supplementary Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors
Supplementary Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors Open
Supplementary information containing Supplementary Methods, Supplementary References, Supplementary Figure 1, and Supplementary Figure 2.
View article: Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors
Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors Open
Burnet postulated that the diversity of T-cell receptors (TCR) allows T cells to protect against the development of cancers that display antigens with a similar, seemingly endless diversity. To test this hypothesis, we developed a strategy…
View article: Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors
Data from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors Open
Burnet postulated that the diversity of T-cell receptors (TCR) allows T cells to protect against the development of cancers that display antigens with a similar, seemingly endless diversity. To test this hypothesis, we developed a strategy…
View article: Supplementary Table S1 from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors
Supplementary Table S1 from Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors Open
Supplementary Table S1
View article: Data from T-Cell Receptor Gene–Modified T Cells with Shared Renal Cell Carcinoma Specificity for Adoptive T-Cell Therapy
Data from T-Cell Receptor Gene–Modified T Cells with Shared Renal Cell Carcinoma Specificity for Adoptive T-Cell Therapy Open
Purpose: Adoptive therapy with genetically engineered T cells carrying redirected antigen specificity is a new option for the treatment of cancer. This approach is not yet available for metastatic renal cell carcinoma (RCC), due to …
View article: methods from Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
methods from Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy Open
constructs, murine HCC model, spheroid and imaging, RCC tissue pathology
View article: Table S3 from Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor–Engineered T Cells for Ovarian Cancer
Table S3 from Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor–Engineered T Cells for Ovarian Cancer Open
Sequences of TCRs for generating TCR-engineered T cells.
View article: Table S1 from Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus
Table S1 from Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus Open
V-J segment usage as well as CDR3 sequences of TCRs isolated from ABabDII mice after immunization with SMF or KLL epitope petide, respectively.