Matthias Schmid
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View article: Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions
Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions Open
Metabolic responses to dietary interventions often show high inter-individual variations, but the factors explaining these variations as well as underlying mechanisms and their interrelation remain largely unknown. Knowing which factors ar…
View article: Differential effects of Nordic and Vegetarian diets on lipid metabolism, gut microbiome and cardiometabolic risk factors: A multi-omic perspective from a randomized clinical intervention trial
Differential effects of Nordic and Vegetarian diets on lipid metabolism, gut microbiome and cardiometabolic risk factors: A multi-omic perspective from a randomized clinical intervention trial Open
Background Beneficial effects of diets with predominance of plant-based foods as fruits, vegetables, whole grain and plant-protein and less animal-based foods, or so-called “ plant-based ” diets, on cardiometabolic risk have been reported.…
View article: Achieving interpretable machine learning by functional decomposition of black-box models into explainable predictor effects
Achieving interpretable machine learning by functional decomposition of black-box models into explainable predictor effects Open
Machine learning (ML) models are often based on complex black-box architectures that are difficult to interpret. This interpretability problem can hinder the use of ML in fields like medicine, ecology, and insurance, and has boosted resear…
View article: Improved Implementation of Tumor Board Decisions: A Retrospective Single Center Observational Study in Germany
Improved Implementation of Tumor Board Decisions: A Retrospective Single Center Observational Study in Germany Open
Most TUB recommendations across ten medical disciplines were fully or partially implemented. However, there remains potential for improvement, particularly in ensuring consistent documentation and integrating patient preferences into clini…
View article: Correction: Dementia as a predictor of palliative care: uncovering patient patterns based on German claims data
Correction: Dementia as a predictor of palliative care: uncovering patient patterns based on German claims data Open
View article: Patient-reported vision impairment in low luminance relates to visual function in age-related macular degeneration: A MACUSTAR study report
Patient-reported vision impairment in low luminance relates to visual function in age-related macular degeneration: A MACUSTAR study report Open
View article: Analysis of drug-drug interactions in spontaneous adverse drug reaction reports from EudraVigilance focusing on psychiatric drugs and somatic medication
Analysis of drug-drug interactions in spontaneous adverse drug reaction reports from EudraVigilance focusing on psychiatric drugs and somatic medication Open
View article: #1498 The role of trimethylamine N-oxide in chronic kidney disease progression and mortality: insights from the GCKD study
#1498 The role of trimethylamine N-oxide in chronic kidney disease progression and mortality: insights from the GCKD study Open
Background and Aims Trimethylamine N-oxide (TMAO) is a gut microbial metabolite derived from dietary phosphatidylcholine and carnitine. Recently, we have shown that TMAO accumulates in patients with chronic kidney disease (CKD), not only d…
View article: ChatGPT as a Tool for Biostatisticians: A Tutorial on Applications, Opportunities, and Limitations
ChatGPT as a Tool for Biostatisticians: A Tutorial on Applications, Opportunities, and Limitations Open
Modern large language models (LLMs) have reshaped the workflows of people across countless fields—and biostatistics is no exception. These models offer novel support in drafting study plans, generating software code, or writing reports. Ho…
View article: Associations Between Structural Phenotype and Polygenic Risk Scores in Intermediate Age-Related Macular Degeneration – A MACUSTAR Report
Associations Between Structural Phenotype and Polygenic Risk Scores in Intermediate Age-Related Macular Degeneration – A MACUSTAR Report Open
Our findings reveal subgroups in iAMD based on genotype-phenotype associations which can help identifying patients at high risk for iAMD and establish new endpoints for clinical trials in iAMD.
View article: A Systematic Categorization of Performance Measures for Estimated Non‐Linear Associations Between an Outcome and Continuous Predictors
A Systematic Categorization of Performance Measures for Estimated Non‐Linear Associations Between an Outcome and Continuous Predictors Open
In regression analysis, associations between continuous predictors and the outcome are often assumed to be linear. However, modeling the associations as non‐linear can improve model fit. Many flexible modeling techniques, like (fractional)…
View article: Interprofessional, risk-adapted medication management in older patients with cancer (IrMa)
Interprofessional, risk-adapted medication management in older patients with cancer (IrMa) Open
View article: Multi-Wavelength Autofluorescence Characteristics and Association With Inflammation in Acute Posterior Multifocal Placoid Pigment Epitheliopathy
Multi-Wavelength Autofluorescence Characteristics and Association With Inflammation in Acute Posterior Multifocal Placoid Pigment Epitheliopathy Open
FAF can aid phenotyping APMPPE lesions and assessing inflammatory activity and should therefore be routinely included in clinical management and studies. Especially 787 nm FAF allows visualization of APMPPE lesions not visible on clinical …
View article: Plea for routine endoscopic tracheostomy tube adjustment
Plea for routine endoscopic tracheostomy tube adjustment Open
Introduction Tracheostomy is one of the standard procedures in intensive care medicine. In the context of tracheostomy tube-, dysphagia- and decannulation management the selection of the appropriate tracheostomy tube model (angle, diameter…
View article: Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort
Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort Open
View article: Factors associated with the completeness of information provided in adverse drug reaction reports of physicians, pharmacists and consumers from Germany
Factors associated with the completeness of information provided in adverse drug reaction reports of physicians, pharmacists and consumers from Germany Open
View article: Disease stage–specific atrophy markers in Alzheimer's disease
Disease stage–specific atrophy markers in Alzheimer's disease Open
INTRODUCTION Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrop…
View article: Severe drug-associated anaphylaxis: a complementary descriptive analyses of registry cases and spontaneous reports
Severe drug-associated anaphylaxis: a complementary descriptive analyses of registry cases and spontaneous reports Open
Purpose Drugs are among the most common triggers of severe anaphylactic reactions in adults. The aim of our study was to identify the most frequently suspected drugs and associated factors of severe drug-associated anaphylactic reactions i…
View article: Evidence for a transgenerational mutational signature from ionizing radiation exposure in humans
Evidence for a transgenerational mutational signature from ionizing radiation exposure in humans Open
View article: Ellipsoid zone reflectivity as a functional imaging biomarker for age-related macular degeneration: a MACUSTAR study report
Ellipsoid zone reflectivity as a functional imaging biomarker for age-related macular degeneration: a MACUSTAR study report Open
View article: Smartphone-based detection of memory decline in prodromal Alzheimer’s disease
Smartphone-based detection of memory decline in prodromal Alzheimer’s disease Open
The slow progression of Alzheimer’s disease (AD) poses a challenge for the rapid and individual quantification of early disease-driven cognitive decline. Here, we show that frequently administered remote and unsupervised digital cognitive …
View article: Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease
Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is characterised by the accumulation of beta-amyloid (Aβ) and tau proteins, leading to neurodegeneration and cognitive decline. While Aβ and tau are known to disrupt synaptic function, the mechanisms linking these …
View article: GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy
GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy Open
View article: Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema
Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema Open
Background Angioedema (AE) rarely occurs as a potentially life‐threatening adverse drug reaction (ADR) to angiotensin‐converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). The aim of the present study was to investiga…
View article: Measurement properties of the German version of the birth satisfaction scale-revised (BSS-R) in women with pre-existing medical conditions and high-risk pregnancy
Measurement properties of the German version of the birth satisfaction scale-revised (BSS-R) in women with pre-existing medical conditions and high-risk pregnancy Open
Background The Birth Satisfaction Scale-Revised (BSS-R) is a validated questionnaire for assessment of childbirth experience which has been translated into many languages. It is the instrument of choice in the International Consortium for …
View article: Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease Open
View article: Model‐Based Recursive Partitioning for Discrete Event Times
Model‐Based Recursive Partitioning for Discrete Event Times Open
Model‐based recursive partitioning (MOB) is used to identify subgroups based on various outcome measures, including time‐to‐event outcomes. Discrete time‐to‐event data are typically fitted using the generalized linear model (GLM) framework…
View article: An analysis of spontaneous adverse drug reaction reports of psychiatric patients stratified by reporter type provides differentiated data
An analysis of spontaneous adverse drug reaction reports of psychiatric patients stratified by reporter type provides differentiated data Open
Introduction In Germany, psychiatric drugs are one of the most frequently prescribed drug class with more than two billion defined daily doses. As a consequence, a high number of patients carries a potential risk to develop an adverse drug…
View article: Characteristics and outcomes of older patients undergoing out‐ versus inpatient surgery in Europe. A secondary analysis of the Peri‐interventional Outcome Study in the Elderly (<scp>POSE</scp>)
Characteristics and outcomes of older patients undergoing out‐ versus inpatient surgery in Europe. A secondary analysis of the Peri‐interventional Outcome Study in the Elderly (<span>POSE</span>) Open
Background The number of older patients undergoing surgical procedures with anaesthesia care is projected to rise. In order to cope with the increased demand, the expansion of outpatient surgery may play a decisive role. We aim to investig…
View article: Disease stage-specific atrophy markers in Alzheimer’s disease
Disease stage-specific atrophy markers in Alzheimer’s disease Open
INTRODUCTION Structural MRI often lacks diagnostic, prognostic, and monitoring value in Alzheimer’s disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal MRI readouts for different use cas…