Matthias Schoenberger
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View article: Disease Onset and Burden in Patients With Chronic Bronchitis and COPD: A Real-World Evidence Study
Disease Onset and Burden in Patients With Chronic Bronchitis and COPD: A Real-World Evidence Study Open
View article: Disease Onset and Burden in Patients With Chronic Bronchitis and COPD: A Real-World Evidence Study
Disease Onset and Burden in Patients With Chronic Bronchitis and COPD: A Real-World Evidence Study Open
These results highlight the importance of increased attention to CB. CB often precedes the diagnosis of COPD and subsequently leads to high HCRU. Interventions to better manage CB and prevent the progression of CB to COPD could improve mor…
View article: Novel Far-Red Fluorescent 1,4-Dihydropyridines for L-Type Calcium Channel Imaging
Novel Far-Red Fluorescent 1,4-Dihydropyridines for L-Type Calcium Channel Imaging Open
Upregulation of L-type calcium channels (LTCCs) is implicated in a range of cardiovascular and neurological disorders. Therefore, the development of toolboxes that unlock fast imaging protocols in live cells is coveted. Herein, we report a…
View article: Novel far-red fluorescent 1,4-dihydropyridines for L-type calcium channel imaging
Novel far-red fluorescent 1,4-dihydropyridines for L-type calcium channel imaging Open
Upregulation of L-type calcium channels (LTCCs) is implicated in a range of cardiovascular and neurological disorders. Therefore, the development of toolboxes that unlocks fast imaging protocols in live cells are coveted. Herein, we report…
View article: Multimorbidities in COPD are Associated With Increased Exacerbations and Health Care Resource Utilization in Real-World Patients from a U.S. Database
Multimorbidities in COPD are Associated With Increased Exacerbations and Health Care Resource Utilization in Real-World Patients from a U.S. Database Open
These real-world data confirm that GERD, diabetes, and osteoporosis are common morbidities in patients with COPD and, moreover, that they affect frequency of exacerbation and HCRU. Determining and addressing the mechanisms behind the syste…
View article: Novel far-red fluorescent 1,4-dihydropyridines for L-type calcium channels imaging
Novel far-red fluorescent 1,4-dihydropyridines for L-type calcium channels imaging Open
Upregulation of L-type calcium channels (LTCCs) is implicated in a range of cardiovascular and neurological disorders. Therefore, the development of toolboxes that unlocks fast imaging protocols in live cells are coveted. Herein, we report…
View article: Impact of COVID-19 measures on exacerbation rates and healthcare visits in US asthma patients
Impact of COVID-19 measures on exacerbation rates and healthcare visits in US asthma patients Open
Objective: To compare exacerbation rates and healthcare resource utilization (HCRU) in real-world patients in the United States who had moderate-to-severe asthma on medium- or high-dose inhaled corticosteroid/long-acting β 2 -agonist thera…
View article: Long-term functional cardiac changes in takotsubo syndrome
Long-term functional cardiac changes in takotsubo syndrome Open
Background Takotsubo syndrome has long been thought to be a benign condition once the acute event has been overcome. However, an increasing number of studies suggest that there might be long-term consequences. The aim of the present study …
View article: Cystic fibrosis transmembrane conductance regulator in COPD: a role in respiratory epithelium and beyond
Cystic fibrosis transmembrane conductance regulator in COPD: a role in respiratory epithelium and beyond Open
The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel for transport of chloride and bicarbonate anions. Functional roles of CFTR have been identified in a broad range of cell types including epithelial, en…
View article: <i>In Vivo</i> [<sup>18</sup>F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates
<i>In Vivo</i> [<sup>18</sup>F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates Open
As one of the major excitatory ion channels in the brain, NMDA receptors have been a leading research target for neuroscientists, physicians, medicinal chemists, and pharmaceutical companies for decades. Molecular imaging of NMDA receptors…
View article: Molecular Imaging of Cardiac Metabolism, Innervation, and Conduction
Molecular Imaging of Cardiac Metabolism, Innervation, and Conduction Open
Cardiac diseases have complex molecular origins. However, current clinical diagnostic tools are often inadequate to uncover specific molecular components of cardiac pathologies. Thus, we are still lacking a detailed understanding of diseas…
View article: Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine
Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine Open
The key function of the heart, a well-orchestrated series of contractions, is controlled by cardiac action potentials. These action potentials are initiated and propagated by a single isoform of voltage gated sodium channels – SCN5A. Howev…