Matthieu Jouffroy
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View article: Transfer Hydrodehalogenation of Aryl Halides Mediated by [Pd(IPr*)(cinnamyl)Cl]
Transfer Hydrodehalogenation of Aryl Halides Mediated by [Pd(IPr*)(cinnamyl)Cl] Open
We report the dehalogenation of aryl halides mediated by a palladium NHC (N-Heterocyclic Carbene) catalyst in alcohol solvents and using potassium phosphate as a mild base. A broad range of substrates, including sterically congested…
View article: Suzuki–Miyaura Coupling of Pinacolboronic Esters Catalyzed by a Well-Defined Palladium <i>N</i>-Heterocyclic Carbene (NHC) Catalyst
Suzuki–Miyaura Coupling of Pinacolboronic Esters Catalyzed by a Well-Defined Palladium <i>N</i>-Heterocyclic Carbene (NHC) Catalyst Open
We report a versatile synthetic method for coupling heteroaryl chlorides and bromides with (hetero)-aryl pinacolboronic esters of pharmaceutical interest at low catalyst loading of a well-defined palladium-NHC catalyst providing products i…
View article: <i>Cis</i> ‐Chelating Diphosphanes for Intracavity Nickel(II)‐Catalyzed Ethylene Oligomerization
<i>Cis</i> ‐Chelating Diphosphanes for Intracavity Nickel(II)‐Catalyzed Ethylene Oligomerization Open
Four cis ‐chelating diphosphanes derived from cyclodextrins (CDs), each featuring a distinct intracavity environment, compel Ni II or Pd II metal centers to reside within α ‐ or β ‐CD cavities. Nickel(II) complexes of these metal‐confining…
View article: A Well‐Defined Pd‐NHC Pre‐Catalyst for the Borylation of Aryl Chlorides
A Well‐Defined Pd‐NHC Pre‐Catalyst for the Borylation of Aryl Chlorides Open
We report on the design of a new well‐defined Pd‐NHC pre‐catalyst [Pd(IMes Me )(cinnamyl)Cl] as effective catalyst in the Miyaura borylation of a series of aryl chlorides. This complex was designed and developed after a screening of differ…
View article: Penta- <i>versus</i> hexa-coordinated iridium catalysts control the reactivity of the direct reductive amination between aliphatic amines and aliphatic ketones: a DFT-guided mechanism
Penta- <i>versus</i> hexa-coordinated iridium catalysts control the reactivity of the direct reductive amination between aliphatic amines and aliphatic ketones: a DFT-guided mechanism Open
The mechanism of the iridium-catalysed direct reductive amination between aliphatic partners was studied by DFT calculations leading to important changes in the rate-determining step depending on the nature of the ligand coordinating to ir…
View article: Stabilization of Luminescent Mononuclear Three‐Coordinate Cu<sup>I</sup> Complexes by Two Distinct Cavity‐Shaped Diphosphanes Obtained from a Single α‐Cyclodextrin Precursor
Stabilization of Luminescent Mononuclear Three‐Coordinate Cu<sup>I</sup> Complexes by Two Distinct Cavity‐Shaped Diphosphanes Obtained from a Single α‐Cyclodextrin Precursor Open
Slightly different reaction conditions afforded two distinct cavity‐shaped cis ‐chelating diphosphanes from the same starting materials, namely diphenyl(2‐phosphanylphenyl)phosphane and an α–cyclodextrin‐derived dimesylate. Thanks to their…
View article: Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1
Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1 Open
Myeloid cell leukemia-1 (MCL-1) is a member of the antiapoptotic BCL-2 proteins family and a key regulator of mitochondrial homeostasis. Overexpression of MCL-1 is found in many cancer cells and contributes to tumor progression, which make…
View article: CCDC 2129686: Experimental Crystal Structure Determination
CCDC 2129686: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2129687: Experimental Crystal Structure Determination
CCDC 2129687: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2129688: Experimental Crystal Structure Determination
CCDC 2129688: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2129684: Experimental Crystal Structure Determination
CCDC 2129684: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2129685: Experimental Crystal Structure Determination
CCDC 2129685: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Iridium‐Catalyzed Direct Reductive Amination of Ketones and Secondary Amines: Breaking the Aliphatic Wall
Iridium‐Catalyzed Direct Reductive Amination of Ketones and Secondary Amines: Breaking the Aliphatic Wall Open
Direct reductive amination (DRA) is a ubiquitous reaction in organic chemistry. This transformation between a carbonyl group and an amine is most often achieved by using a super stoichiometric amount of hazardous hydride reagents, thus bei…
View article: Regioselective Diversification of 2,1-Borazaronaphthalenes: Unlocking Isosteric Space via C–H Activation
Regioselective Diversification of 2,1-Borazaronaphthalenes: Unlocking Isosteric Space via C–H Activation Open
Methods for the regioselective C-H borylation and subsequent cross-coupling of the 2,1-borazaronaphthalene core are reported. Azaborines are dependent on B-N/C═C isosterism when employed in strategies for developing diverse heterocyclic sc…
View article: CCDC 1551365: Experimental Crystal Structure Determination
CCDC 1551365: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1546409: Experimental Crystal Structure Determination
CCDC 1546409: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1551364: Experimental Crystal Structure Determination
CCDC 1551364: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Preparation of Diisopropylammonium Bis(catecholato)cyclohexylsilicate
Preparation of Diisopropylammonium Bis(catecholato)cyclohexylsilicate Open
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View article: Method for Accessing Nitrogen-Containing, <i>B</i>-Heteroaryl-Substituted 2,1-Borazaronaphthalenes
Method for Accessing Nitrogen-Containing, <i>B</i>-Heteroaryl-Substituted 2,1-Borazaronaphthalenes Open
The azaborine motif provides a mimic of aromatic systems through replacement of a C═C bond with a B-N bond. In particular, 2,1-borazaronaphthalenes, accessible through robust methods of synthesis and subsequent functionalization, afford an…
View article: C(sp<sup>3</sup>)–C(sp<sup>2</sup>) cross-coupling of alkylsilicates with borylated aryl bromides – an iterative platform to alkylated aryl- and heteroaryl boronates
C(sp<sup>3</sup>)–C(sp<sup>2</sup>) cross-coupling of alkylsilicates with borylated aryl bromides – an iterative platform to alkylated aryl- and heteroaryl boronates Open
Primary and secondary ammonium alkylsilicates undergo facile C(sp3)–C(sp2) cross-coupling with borylated aryl bromides under mild photoredox/nickel dual catalysis conditions.
View article: Single-Electron Transmetalation via Photoredox/Nickel Dual Catalysis: Unlocking a New Paradigm for sp<sup>3</sup>–sp<sup>2</sup> Cross-Coupling
Single-Electron Transmetalation via Photoredox/Nickel Dual Catalysis: Unlocking a New Paradigm for sp<sup>3</sup>–sp<sup>2</sup> Cross-Coupling Open
The important role of transition metal-catalyzed cross-coupling in expanding the frontiers of accessible chemical territory is unquestionable. Despite empowering chemists with Herculean capabilities in complex molecule construction, contem…
View article: Accessing Elaborated 2,1-Borazaronaphthalene Cores Using Photoredox/Nickel Dual-Catalytic Functionalization
Accessing Elaborated 2,1-Borazaronaphthalene Cores Using Photoredox/Nickel Dual-Catalytic Functionalization Open
A highly effective method for derivatizing 2,1-borazaronaphthalene cores using ammonium alkylbis(catecholato)silicates via photoredox/nickel dual catalysis is reported. By forging C(sp)(3)-C(sp)(2) bonds via this approach, alkyl fragments …
View article: Thioetherification via Photoredox/Nickel Dual Catalysis
Thioetherification via Photoredox/Nickel Dual Catalysis Open
Hypervalent alkylsilicates represent new and readily accessible precursors for the generation of alkyl radicals under photoredox conditions. Alkyl radicals generated from such silicates serve as effective hydrogen atom abstractors from thi…
View article: Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis
Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis Open
Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp(3)-Csp(2) bonds through the transfer of alkyl radicals under very mild reaction conditions. A general procedure for t…
View article: Base-FreePhotoredox/Nickel Dual-Catalytic Cross-Couplingof Ammonium Alkylsilicates
Base-FreePhotoredox/Nickel Dual-Catalytic Cross-Couplingof Ammonium Alkylsilicates Open
View article: Base-Free Photoredox/Nickel Dual-Catalytic Cross-Coupling of Ammonium Alkylsilicates
Base-Free Photoredox/Nickel Dual-Catalytic Cross-Coupling of Ammonium Alkylsilicates Open
Single-electron transmetalation is recognized as an enabling technology for the mild transfer of alkyl groups to transition metal catalysts in cross-coupling reactions. Hypercoordinate silicates represent a new and improved class of radica…
View article: Cyclodextrin and phosphorus(<scp>iii</scp>): a versatile combination for coordination chemistry and catalysis
Cyclodextrin and phosphorus(<span>iii</span>): a versatile combination for coordination chemistry and catalysis Open
The relevance of cyclodextrins equipped with P(iii) atoms in coordination chemistry and homogeneous catalysis is discussed.