Matthijs Cluitmans
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View article: WEIGHT LOSS REVERSES ADVERSE STRUCTURAL, ELECTROPHYSIOLOGICAL AND AUTONOMIC REMODELLING IN OBESITY
WEIGHT LOSS REVERSES ADVERSE STRUCTURAL, ELECTROPHYSIOLOGICAL AND AUTONOMIC REMODELLING IN OBESITY Open
Background Obesity is a global health problem that associates with cardiovascular disease and is an independent risk factor for cardiac arrhythmias. We previously showed QTc interval prolongs with increasing adiposity at a population level…
View article: The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability
The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability Open
The apicobasal repolarization gradient (ABRG) plays an important role in determining the sequence of ventricular repolarization, but the effects of sex and age on ABRG are unknown. In this study, we investigate the age‐ and sex‐related dif…
View article: The influence of delayed ventricular activation on cardiac repolarization: insights from electrocardiographic imaging
The influence of delayed ventricular activation on cardiac repolarization: insights from electrocardiographic imaging Open
Background In the normal human heart, the polarity of the T-wave is concordant with the QRS-complex. This phenomenon is often explained by the negative relationship between the activation (AT) and repolarization time (RT). Patients with a …
View article: Premature ventricular complexes in survivors of idiopathic ventricular fibrillation: short-coupled near major arrhythmic events, but longer-coupled remotely
Premature ventricular complexes in survivors of idiopathic ventricular fibrillation: short-coupled near major arrhythmic events, but longer-coupled remotely Open
Background/Introduction Idiopathic ventricular fibrillation (VF) and polymorphic ventricular tachycardia (pVT) are often triggered by short-coupled premature ventricular complexes (SC-PVCs), with coupling intervals (CI) <350 ms. However…
View article: The value of vectorcardiographic T-wave area in assessing repolarization heterogeneity: insights from ECG-imaging
The value of vectorcardiographic T-wave area in assessing repolarization heterogeneity: insights from ECG-imaging Open
Background Repolarization abnormalities play an important role in arrhythmogenesis in patients with and without structural heart disease. In clinical practice, the QT interval from the 12-lead ECG is commonly used to assess arrhythmic risk…
View article: Characterization of static and dynamic depolarization and repolarization characteristics in the short-QT syndrome
Characterization of static and dynamic depolarization and repolarization characteristics in the short-QT syndrome Open
Background The short-QT syndrome (SQTS) is a rare cardiac disorder associated with abnormally short repolarization duration and increased risk of ventricular tachyarrhythmia (VT). In-vivo depolarization and repolarization patterns in patie…
View article: Static and dynamic abnormalities in electromechanical and autonomic cardiac function characterize the proarrhythmic substrate in the long-QT syndrome
Static and dynamic abnormalities in electromechanical and autonomic cardiac function characterize the proarrhythmic substrate in the long-QT syndrome Open
Background Arrhythmogenesis in long-QT syndrome (LQTS) is driven by electrical instabilities, proarrhythmic electromechanical reciprocity, and swift autonomic nervous system (ANS) fluctuations. Purpose Characterizing the proarrhythmic elec…
View article: Deep learning based estimation of heart surface potentials
Deep learning based estimation of heart surface potentials Open
View article: 3D target definition and initial results from the electroanatomic substrate-guided stereotactic ablative radiotherapy for refractory ventricular tachycardia (ELSTAR-VT)
3D target definition and initial results from the electroanatomic substrate-guided stereotactic ablative radiotherapy for refractory ventricular tachycardia (ELSTAR-VT) Open
Background/introduction Noninvasive stereotactic radiotherapy (STAR) is an emerging transmural ablative therapy for refractory ventricular tachycardia (VT). Delineation of the arrhythmogenic gross target volume (GTV) relies on electrical (…
View article: Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia
Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia Open
Aims There is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic processing approach …
View article: Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging
Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging Open
Aims Although electrical activity of the normal human heart is well characterized by the electrocardiogram, detailed insights into within-subject and between-subject variations of ventricular activation and recovery by noninvasive electroa…
View article: Bariatric surgery partially reverses subclinical proarrhythmic structural, electrophysiological, and autonomic changes in obesity
Bariatric surgery partially reverses subclinical proarrhythmic structural, electrophysiological, and autonomic changes in obesity Open
Obesity is associated with adverse electrophysiological, structural, and autonomic remodeling that is partially reversed after bariatric surgery. These data have important implications for bariatric surgery weight thresholds and weight los…
View article: Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia
Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia Open
Introduction In the clinic, complete characterization of reentrant ventricular tachycardia (VT) circuits using classical electrophysiological criteria and state-of-the-art high density mapping during VT is complex, and often cannot be comp…
View article: The electrical substrate of vectorcardiographic QRS area in cardiac resynchronization therapy: insights from ECG-imaging
The electrical substrate of vectorcardiographic QRS area in cardiac resynchronization therapy: insights from ECG-imaging Open
Background The QRS area shows promise as a vectorcardiographic (VCG) marker for electrical dyssynchrony in patient selection for cardiac resynchronization therapy (CRT). Nevertheless, little information is known about the underlying cardia…
View article: Variant electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging
Variant electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging Open
Background and aims Although electrical activity of the normal human heart is well-characterized by the 12-lead electrocardiogram, detailed insights into within-subject and between-subject variations of ventricular activation and recovery …
View article: The Dutch Idiopathic Ventricular Fibrillation Registry: progress report on the quest to identify the unidentifiable
The Dutch Idiopathic Ventricular Fibrillation Registry: progress report on the quest to identify the unidentifiable Open
Background Idiopathic ventricular fibrillation (iVF) is a rare cause of sudden cardiac arrest and, by definition, a diagnosis of exclusion. Due to the rarity of the disease, previous and current studies are limited by their retrospective d…
View article: Digital twins for cardiac electrophysiology: state of the art and future challenges
Digital twins for cardiac electrophysiology: state of the art and future challenges Open
View article: Strain-controlled electrophysiological wave propagation alters in silico scar-based substrate for ventricular tachycardia
Strain-controlled electrophysiological wave propagation alters in silico scar-based substrate for ventricular tachycardia Open
Introduction: Assessing a patient’s risk of scar-based ventricular tachycardia (VT) after myocardial infarction is a challenging task. It can take months to years after infarction for VT to occur. Also, if selected for ablation therapy, su…
View article: Methodological and Mechanistic Considerations in Local Repolarization Mapping
Methodological and Mechanistic Considerations in Local Repolarization Mapping Open
View article: Deep Learning Based Estimation of Heart Surface Potentials
Deep Learning Based Estimation of Heart Surface Potentials Open
View article: Arrhythmogenic vulnerability of reentrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling
Arrhythmogenic vulnerability of reentrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling Open
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View article: Editorial: Computational methods in cardiac electrophysiology
Editorial: Computational methods in cardiac electrophysiology Open
EDITORIAL article Front. Physiol., 21 June 2023Sec. Cardiac Electrophysiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1231342
View article: Delayed ventricular conduction alters ventricular repolarization in patients with heart failure: an electrocardiographic imaging study
Delayed ventricular conduction alters ventricular repolarization in patients with heart failure: an electrocardiographic imaging study Open
Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Personal grant from the Dutch Heart Foundation. Background In the normal human heart, the polarity of the T-wave is concordant with the QRS compl…
View article: The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest
The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest Open
Sudden cardiac death is often caused by ventricular arrhythmias driven by reentry. Comprehensive characterization of the potential triggers and substrate in survivors of sudden cardiac arrest has provided insights into the trigger-substrat…
View article: Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited
Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited Open
Background: The optimal way to determine repolarization time (RT) from the intracardiac unipolar electrogram (UEG) has been a topic of debate for decades. RT is typically determined by either the Wyatt method or the “alternative method,” w…
View article: High-resolution structural-functional substrate-trigger characterization: Future roadmap for catheter ablation of ventricular tachycardia
High-resolution structural-functional substrate-trigger characterization: Future roadmap for catheter ablation of ventricular tachycardia Open
Introduction Patients with ventricular tachyarrhythmias (VT) are at high risk of sudden cardiac death. When appropriate, catheter ablation is modestly effective, with relatively high VT recurrence and complication rates. Personalized model…
View article: Sensitivity of Repolarization Gradients to Infarct Borderzone Properties Assessed with the Ten Tusscher and Modified Mitchell-Schaeffer Model
Sensitivity of Repolarization Gradients to Infarct Borderzone Properties Assessed with the Ten Tusscher and Modified Mitchell-Schaeffer Model Open
View article: Isogeometric-Mechanics-Driven Electrophysiology Simulations of Ventricular Tachycardia
Isogeometric-Mechanics-Driven Electrophysiology Simulations of Ventricular Tachycardia Open
View article: Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T‐wave parameters
Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T‐wave parameters Open
Background The T wave of the electrocardiogram (ECG) reflects ventricular repolarization. Repolarization heterogeneity is associated with reentrant arrhythmias. Several T‐wave markers (including QT interval) have been associated with ventr…
View article: From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22
From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22 Open
Here, we review the highlights of cardiovascular basic science published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as c…