Mattia Asti
YOU?
Author Swipe
View article: Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization
Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization Open
Monocarboxylate Transporters (MCTs), particularly MCT1, are increasingly recognized as key regulators of cancer metabolism, facilitating lactate exchange and contributing to tumor aggressiveness. Their overexpression in various malignancie…
View article: Thwarting Isomerization through Rigidity: A Promising HBED Derivative for the Chelation of Gallium-68
Thwarting Isomerization through Rigidity: A Promising HBED Derivative for the Chelation of Gallium-68 Open
The hexadentate acyclic ligand, N,N'-di(2-hydroxybenzyl)-(1,2-cyclohexanediamine)-N,N'-diacetic acid (HBCD) designed for the chelation of the positron-emitting radiometal 68Ga was developed by replacing the flexible ethylenediam…
View article: 111Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project
111Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project Open
View article: Bridging pyrimidine hemicurcumin and Cisplatin: Synthesis, coordination chemistry, and in vitro activity assessment of a novel Pt(II) complex
Bridging pyrimidine hemicurcumin and Cisplatin: Synthesis, coordination chemistry, and in vitro activity assessment of a novel Pt(II) complex Open
In the upcoming decades, the incidence and mortality rates of cancer are expected to rise globally, with colorectal and prostate cancers among the most prevalent types. Despite advancements in molecular targeted therapy, platinum-based che…
View article: Navigating through the coordination preferences of heavy alkaline earth metals: Laying the foundations for 223Ra- and 131/135mBa-based targeted alpha therapy and theranostics of cancer
Navigating through the coordination preferences of heavy alkaline earth metals: Laying the foundations for 223Ra- and 131/135mBa-based targeted alpha therapy and theranostics of cancer Open
View article: Biodistribution Assessment of a Novel 68Ga-Labeled Radiopharmaceutical in a Cancer Overexpressing CCK2R Mouse Model: Conventional and Radiomics Methods for Analysis
Biodistribution Assessment of a Novel 68Ga-Labeled Radiopharmaceutical in a Cancer Overexpressing CCK2R Mouse Model: Conventional and Radiomics Methods for Analysis Open
The aim of the present study consists of the evaluation of the biodistribution of a novel 68Ga-labeled radiopharmaceutical, [68Ga]Ga-NODAGA-Z360, injected into Balb/c nude mice through histopathological analysis on bioptic samples and radi…
View article: Chromatographic separation of silver-111 from neutron-irradiated palladium target: toward direct labeling of radiotracers
Chromatographic separation of silver-111 from neutron-irradiated palladium target: toward direct labeling of radiotracers Open
Background Silver-111 is a promising β − -emitting radioisotope with ideal characteristics for targeted radionuclide therapy and associated single photon emission tomography imaging. Its decay properties closely resemble the clinically est…
View article: Chromatographic Separation of Silver-111 from Neutron-Irradiated Palladium Target: Toward Direct Labeling of Radiotracers
Chromatographic Separation of Silver-111 from Neutron-Irradiated Palladium Target: Toward Direct Labeling of Radiotracers Open
Background: Silver-111 is a promising β−-emitting radioisotope with ideal characteristics for targeted radionuclide therapy and associated single photon emission tomography imaging. Its decay properties closely resemble the cli…
View article: Development of Stable Amino-Pyrimidine–Curcumin Analogs: Synthesis, Equilibria in Solution, and Potential Anti-Proliferative Activity
Development of Stable Amino-Pyrimidine–Curcumin Analogs: Synthesis, Equilibria in Solution, and Potential Anti-Proliferative Activity Open
With the clear need for better cancer treatment, naturally occurring molecules represent a powerful inspiration. Recently, curcumin has attracted attention for its pleiotropic anticancer activity in vitro, especially against colorectal and…
View article: Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods
Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods Open
The interest in silver radioisotopes of medical appeal (silver-103, silver-104m,g and silver-111) has been recently awakened by the versatile nature of their nuclear decays, which combine emissions potentially suitable for non-invasive ima…
View article: CCDC 2067484: Experimental Crystal Structure Determination
CCDC 2067484: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Is Smaller Better? Cu<sup>2+</sup>/Cu<sup>+</sup> Coordination Chemistry and Copper-64 Radiochemical Investigation of a 1,4,7-Triazacyclononane-Based Sulfur-Rich Chelator
Is Smaller Better? Cu<sup>2+</sup>/Cu<sup>+</sup> Coordination Chemistry and Copper-64 Radiochemical Investigation of a 1,4,7-Triazacyclononane-Based Sulfur-Rich Chelator Open
The biologically triggered reduction of Cu2+ to Cu+ has been postulated as a possible in vivo decomplexation pathway in 64/67Cu-based radiopharmaceuticals. In an attempt to hinder this phenomenon, we…
View article: Radiolabeled Chalcone Derivatives as Potential Radiotracers for β-Amyloid Plaques Imaging
Radiolabeled Chalcone Derivatives as Potential Radiotracers for β-Amyloid Plaques Imaging Open
Natural products often provide a pool of pharmacologically relevant precursors for the development of various drug-related molecules. In this review, the research performed on some radiolabeled chalcone derivatives characterized by the pre…
View article: Production and characterization of 111Ag radioisotope for medical use in a TRIGA Mark II nuclear research reactor
Production and characterization of 111Ag radioisotope for medical use in a TRIGA Mark II nuclear research reactor Open
View article: Towards in vivo applications of 111Ag perturbed angular correlation of γ-rays (PAC) spectroscopy
Towards in vivo applications of 111Ag perturbed angular correlation of γ-rays (PAC) spectroscopy Open
View article: Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs
Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs Open
Curcumin is known for its therapeutic properties; among these, antioxidant, anti-inflammatory and anti-cancer ones stand out. Besides, curcumin metal complexes have shown widespread application in medicine and can be exploited as lead stru…
View article: Chelation of Theranostic Copper Radioisotopes with S-Rich Macrocycles: From Radiolabelling of Copper-64 to In Vivo Investigation
Chelation of Theranostic Copper Radioisotopes with S-Rich Macrocycles: From Radiolabelling of Copper-64 to In Vivo Investigation Open
Copper radioisotopes are generally employed for cancer imaging and therapy when firmly coordinated via a chelating agent coupled to a tumor-seeking vector. However, the biologically triggered Cu2+-Cu+ redox switching may constrain the in v…
View article: When ring makes the difference: coordination properties of Cu<sup>2+</sup>/Cu<sup>+</sup> complexes with sulfur-pendant polyazamacrocycles for radiopharmaceutical applications
When ring makes the difference: coordination properties of Cu<sup>2+</sup>/Cu<sup>+</sup> complexes with sulfur-pendant polyazamacrocycles for radiopharmaceutical applications Open
The Cu 2+/+ complexes formed by sulfur-containing polyazamacrocycles were studied in aqueous solution using potentiometry, UV-Vis, NMR, EPR, and cyclic voltammetry.
View article: The ISOLPHARM project at LNL: A new production method of high specific activity radionuclides towards innovative radiopharmaceuticals
The ISOLPHARM project at LNL: A new production method of high specific activity radionuclides towards innovative radiopharmaceuticals Open
View article: Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry
Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry Open
Curcumin is a natural occurring molecule that has aroused much interest among researchers over the years due to its pleiotropic set of biological properties. In the nuclear medicine field, radiolabelled curcumin and curcumin derivatives ha…
View article: Methods for preparation and administration of lutetium-177 oxodotreotide 3.7 GBq: proceedings from an Italian advisory board
Methods for preparation and administration of lutetium-177 oxodotreotide 3.7 GBq: proceedings from an Italian advisory board Open
View article: Preliminary Study of a 1,5-Benzodiazepine-Derivative Labelled with Indium-111 for CCK-2 Receptor Targeting
Preliminary Study of a 1,5-Benzodiazepine-Derivative Labelled with Indium-111 for CCK-2 Receptor Targeting Open
The cholecystokinin-2 receptor (CCK-2R) is overexpressed in several human cancers but displays limited expression in normal tissues. For this reason, it is a suitable target for developing specific radiotracers. In this study, a nastorazep…
View article: Complete response of cutaneous SCC to topical treatment with ascorbic acid solution: A case report
Complete response of cutaneous SCC to topical treatment with ascorbic acid solution: A case report Open
Clinical use of topical ascorbic acid solution could have both the role as an adjunct to consolidated therapies and as an alternative to them, for the treatment of BCC and SCC of the skin.
View article: Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms: A Step Toward Silver-111 Labeled Radiopharmaceuticals
Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms: A Step Toward Silver-111 Labeled Radiopharmaceuticals Open
With a half-life of 7.45 days, silver-111 (βmax 1.04 MeV, Eγ 245.4 keV [Iγ 1.24%], Eγ 342.1 keV [Iγ 6.7%]) is a promising candidate for targeted cancer ther…
View article: 64Cu and fluorescein labeled anti-miRNA peptide nucleic acids for the detection of miRNA expression in living cells
64Cu and fluorescein labeled anti-miRNA peptide nucleic acids for the detection of miRNA expression in living cells Open
View article: Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies
Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies Open
Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women worldwide. We have recently reported that curcuminoid complexes labelled with gallium-68 have demonstrated preferen…
View article: Curcumin derivatives and Aβ-fibrillar aggregates: An interactions’ study for diagnostic/therapeutic purposes in neurodegenerative diseases
Curcumin derivatives and Aβ-fibrillar aggregates: An interactions’ study for diagnostic/therapeutic purposes in neurodegenerative diseases Open
View article: Diagnostic performances of [18F]fluorocholine positron emission tomography in brain tumors
Diagnostic performances of [18F]fluorocholine positron emission tomography in brain tumors Open
Our results, worthy of further investigations, show high diagnostic performances of [18F]FECH PET/CT, and a correlation between PET imaging derived parameters and survival.
View article: New curcumin-derived ligands and their affinity towards Ga<sup>3+</sup>, Fe<sup>3+</sup> and Cu<sup>2+</sup>: spectroscopic studies on complex formation and stability in solution
New curcumin-derived ligands and their affinity towards Ga<sup>3+</sup>, Fe<sup>3+</sup> and Cu<sup>2+</sup>: spectroscopic studies on complex formation and stability in solution Open
Chemico-physical properties, metal chelating ability, antiproliferative activity and DNA binding of new curcuminoids with improved stability.
View article: Uptake of Ga-curcumin derivatives in different cancer cell lines: Toward the development of new potential 68 Ga-labelled curcuminoids-based radiotracers for tumour imaging
Uptake of Ga-curcumin derivatives in different cancer cell lines: Toward the development of new potential 68 Ga-labelled curcuminoids-based radiotracers for tumour imaging Open