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View article: Intrawound vancomycin powder for prevention of surgical site infections after open instrumented posterior spinal fusion (VANCO Trial)—methodology of a randomized, controlled, multicenter study
Intrawound vancomycin powder for prevention of surgical site infections after open instrumented posterior spinal fusion (VANCO Trial)—methodology of a randomized, controlled, multicenter study Open
ClinicalTrials.gov NCT04017468.
View article: Anticoagulant versus antiplatelet treatment for secondary stroke prevention in patients with active cancer
Anticoagulant versus antiplatelet treatment for secondary stroke prevention in patients with active cancer Open
Background Approximately 5–10% of patients with acute ischemic stroke (AIS) have known active cancer. These patients are at high risk for both recurrent AIS and major bleeding. The optimal antithrombotic strategy for cancer-related stroke …
View article: Motor evoked potential monitoring and continuous dynamic mapping: Warning criteria during surgery on motor eloquent intra-axial brain tumors
Motor evoked potential monitoring and continuous dynamic mapping: Warning criteria during surgery on motor eloquent intra-axial brain tumors Open
This study validates IONM warning criteria.
View article: Once- versus twice-daily direct oral anticoagulants after ischemic stroke in atrial fibrillation – A post-hoc analysis of the ELAN trial
Once- versus twice-daily direct oral anticoagulants after ischemic stroke in atrial fibrillation – A post-hoc analysis of the ELAN trial Open
Introduction: Whether the risk-benefit profile of once-daily versus twice-daily direct oral anticoagulants (DOAC) differs after atrial fibrillation(AF)-associated ischemic stroke is unclear. We explored this in a post-hoc analysis of ELAN …
View article: Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes
Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes Open
Background Despite universal coverage, inequities persist in acute coronary syndrome (ACS) care. This study examines how educational levels impact the quality and outcomes of health care. Methods A cohort of ACS patients hospitalized in fi…
View article: Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study
Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study Open
Background: The asymmetry of cortical veins in susceptibility weighted imaging (SWI) in MRI might be a biomarker for migraine aura and cortical spreading depression (CSD). The aim of this study was to assess in humans if SWI asymmetry can …
View article: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST) Open
View article: A bicentric study on the prevalence and clinical relevance of subarachnoid hyperdensities on flat-detector CT after thrombectomy in dominant, co-dominant, and non-dominant M2 occlusions
A bicentric study on the prevalence and clinical relevance of subarachnoid hyperdensities on flat-detector CT after thrombectomy in dominant, co-dominant, and non-dominant M2 occlusions Open
Background Subarachnoid hyperdensities (SH) on flat-detector CT (FDCT) after mechanical thrombectomy (MT) are associated with less favorable clinical outcomes. We aimed to further elucidate the prevalence and clinical significance of SH fo…
View article: Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis
Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis Open
Background and Purpose Antiplatelets are often used before direct oral anticoagulant (DOACs) initiation after an acute ischemic stroke related to atrial fibrillation (AF), but the evidence is weak. Here, we explored the risks and benefits …
View article: Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation
Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation Open
View article: Reconsideration of the resection strategy of eloquent brain metastasis in the era of postoperative stereotactic radiotherapy: a comparative analysis with non-eloquent metastasis
Reconsideration of the resection strategy of eloquent brain metastasis in the era of postoperative stereotactic radiotherapy: a comparative analysis with non-eloquent metastasis Open
Purpose To decrease the recurrence rate after complete resection of a brain metastasis, removal of a surgical safety margin is advocated. This is not always feasible when resecting a metastasis in an eloquent location. We aimed to assess t…
View article: Sonolysis during carotid endarterectomy: randomised controlled trial
Sonolysis during carotid endarterectomy: randomised controlled trial Open
Objective To evaluate the effectiveness and safety of sonolysis using a low intensity 2 MHz pulsed wave ultrasound beam during carotid endarterectomy. Design Multicentre, phase 3, double blind, randomised controlled trial. Setting 16 Europ…
View article: How Good Are Neurologists? A Diagnostic Accuracy Study on the Performance of Neurologists in the Emergency Room
How Good Are Neurologists? A Diagnostic Accuracy Study on the Performance of Neurologists in the Emergency Room Open
Background In people with suspected stroke the first assessment occurs under time pressure in the emergency department and is based solely on clinical information. Working hypotheses include mechanism and localization of the clinical defic…
View article: Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation
Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation Open
Importance The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation–associated ischemic stroke is unclear. Objective To investigate whether early DOAC treatment is associated with a ne…
View article: Motor evoked potential monitoring and continuous dynamic mapping: warning criteria during surgery on 473 intra-axial brain tumors
Motor evoked potential monitoring and continuous dynamic mapping: warning criteria during surgery on 473 intra-axial brain tumors Open
View article: Reconsideration of the surgical safety margin around brain metastasis in the era of postoperative stereotactic radiosurgery
Reconsideration of the surgical safety margin around brain metastasis in the era of postoperative stereotactic radiosurgery Open
View article: Motor evoked potential monitoring and continuous dynamic mapping: warning criteria during surgery on 190 glioblastomas
Motor evoked potential monitoring and continuous dynamic mapping: warning criteria during surgery on 190 glioblastomas Open
View article: Field-testing the explicit diagnostic criteria for transient ischemic attack: a diagnostic accuracy study
Field-testing the explicit diagnostic criteria for transient ischemic attack: a diagnostic accuracy study Open
Background and aim Explicit diagnostic criteria for transient ischemic attack (TIA) (EDCT) have been recently proposed based on the assumption, that a migraine aura-like symptom is not typical for a TIA. However, migraine-like symptoms hav…
View article: The potential to prevent unnecessary emergency department visits by timely diagnosis of migraine–A prospective observational study
The potential to prevent unnecessary emergency department visits by timely diagnosis of migraine–A prospective observational study Open
Aim Successful acute migraine treatment potentially prevents emergency room (ER) consultations but requires that the diagnosis of migraine was given earlier. The aim of this study is to quantify the problem of missed migraine diagnosis pri…
View article: Efficacy and Safety of Dolutegravir Plus Emtricitabine vs Combined Antiretroviral Therapy for the Maintenance of HIV Suppression: Results Through Week 144 of the SIMPL’HIV Trial
Efficacy and Safety of Dolutegravir Plus Emtricitabine vs Combined Antiretroviral Therapy for the Maintenance of HIV Suppression: Results Through Week 144 of the SIMPL’HIV Trial Open
The SIMPL’HIV study investigated whether switching to dolutegravir (DTG) + emtricitabine (FTC) was noninferior to continuing combined antiretroviral therapy for maintaining HIV-1 suppression at 144 weeks. The study demonstrated that viral …
View article: Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes
Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes Open
View article: Mortality in acute ischemic stroke patients with new cancer diagnosed during the index hospitalization versus after discharge
Mortality in acute ischemic stroke patients with new cancer diagnosed during the index hospitalization versus after discharge Open
View article: Electrophysiological differences of randomized deep sedation with dexmedetomidine versus propofol
Electrophysiological differences of randomized deep sedation with dexmedetomidine versus propofol Open
View article: Long-term sequelae after viral meningitis and meningoencephalitis are frequent, even in mildly affected patients, a prospective observational study
Long-term sequelae after viral meningitis and meningoencephalitis are frequent, even in mildly affected patients, a prospective observational study Open
Introduction An increasing number of studies demonstrate that viral meningitis and meningoencephalitis, even those with a mild course of meningitis, can result in residual sequelae. Methods We aimed to investigate the long-term outcome in …
View article: Factors impacting D-dimer levels in patients with acute ischemic cerebrovascular events
Factors impacting D-dimer levels in patients with acute ischemic cerebrovascular events Open
The time from symptom onset may affect D-dimer levels in patients with AIS but not those with TIA. Further studies confirming these findings and validating time-specific variations are needed to enable D-dimer levels to be used efficiently…
View article: External Validation of a Model for Persistent Perfusion Deficit in Patients With Incomplete Reperfusion After Thrombectomy
External Validation of a Model for Persistent Perfusion Deficit in Patients With Incomplete Reperfusion After Thrombectomy Open
The externally validated model had adequate predictive accuracy and discrimination. Depending on the acceptable threshold probability, the model accurately predicts persistent incomplete reperfusion and may advise physicians whether additi…
View article: Correction to: Flat-panel Detector Perfusion Imaging and Conventional Multidetector Perfusion Imaging in Patients with Acute Ischemic Stroke
Correction to: Flat-panel Detector Perfusion Imaging and Conventional Multidetector Perfusion Imaging in Patients with Acute Ischemic Stroke Open
View article: Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation
Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation Open
Importance Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown. Objective To assess whether infarct size modifies…
View article: Early Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized Controlled ELAN Trial
Early Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized Controlled ELAN Trial Open
BACKGROUND: Whether hemorrhagic transformation (HT) modifies the treatment effect of early compared with late initiation of direct oral anticoagulation in people with ischemic stroke and atrial fibrillation is unknown. METHODS: This is a p…
View article: Chronic Pain in Patients with Spinal Muscular Atrophy in Switzerland: A Query to the Spinal Muscular Atrophy Registry
Chronic Pain in Patients with Spinal Muscular Atrophy in Switzerland: A Query to the Spinal Muscular Atrophy Registry Open
Background and Objectives: Chronic pain is a common symptom in various types of neuromuscular disorders. However, for patients with spinal muscular atrophy (SMA), the literature regarding chronic pain is scarce. Thus, this study assessed t…