Mattia Busana
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View article: Predictors of VILI risk: driving pressure, 4DPRR and mechanical power ratio—an experimental study
Predictors of VILI risk: driving pressure, 4DPRR and mechanical power ratio—an experimental study Open
Background Ventilator-induced lung injury (VILI) is one of the side effects of mechanical ventilation during ARDS; a prerequisite for averting it is the quantification of its risk factors associated with a given ventilatory setting. Many c…
View article: Rethinking ARDS classification: oxygenation impairment fails to predict VILI risk
Rethinking ARDS classification: oxygenation impairment fails to predict VILI risk Open
View article: Impact of Fluid Balance on the Development of Lung Injury
Impact of Fluid Balance on the Development of Lung Injury Open
Rationale: The pathophysiological relationship among fluid administration, fluid balance, and mechanical ventilation in the development of lung injury is unclear. Objectives: To quantify the relative contributions of mechanic…
View article: Does the Intensity of Therapy Correspond to the Severity of Acute Respiratory Distress Syndrome (ARDS)?
Does the Intensity of Therapy Correspond to the Severity of Acute Respiratory Distress Syndrome (ARDS)? Open
Objectives: The intensity of respiratory treatment in acute respiratory distress syndrome (ARDS) is traditionally adjusted based on oxygenation severity, as defined by the mild, moderate, and severe Berlin classifications. However, ventila…
View article: Correction: Mechanical power ratio threshold for ventilator-induced lung injury
Correction: Mechanical power ratio threshold for ventilator-induced lung injury Open
View article: Acute renal response to changes in carbon dioxide in mechanically ventilated female pigs
Acute renal response to changes in carbon dioxide in mechanically ventilated female pigs Open
Kidney response to acute and mechanically induced variation in ventilation associated with different levels of PEEP has not been investigated. We aimed to quantify the effect of ventilatory settings on renal acid–base compensation. Forty‐o…
View article: Mechanical power ratio threshold for ventilator-induced lung injury
Mechanical power ratio threshold for ventilator-induced lung injury Open
Rationale Mechanical power (MP) is a summary variable incorporating all causes of ventilator-induced-lung-injury (VILI). We expressed MP as the ratio between observed and normal expected values (MP ratio ). Objective To define a threshold …
View article: Electrical Impedance Tomography: A Monitoring Tool for Ventilation-induced Lung Injury
Electrical Impedance Tomography: A Monitoring Tool for Ventilation-induced Lung Injury Open
"Electrical Impedance Tomography: A Monitoring Tool for Ventilation Induced Lung Injury." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data
Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data Open
Background The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney failure and the hemo…
View article: Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation
Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation Open
This paper challenges the assumed equivalence between changes in plasma strong ion difference (SID) and whole blood base excess (BE) during in vitro acidosis. We highlight that redistribution of strong ions, in the form of albumin ionic-bi…
View article: Impact of mechanical power and positive end expiratory pressure on central vs. mixed oxygen and carbon dioxide related variables in a population of female piglets
Impact of mechanical power and positive end expiratory pressure on central vs. mixed oxygen and carbon dioxide related variables in a population of female piglets Open
Introduction The use of the pulmonary artery catheter has decreased overtime; central venous blood gases are generally used in place of mixed venous samples. We want to evaluate the accuracy of oxygen and carbon dioxide related parameters …
View article: Estimation of normal lung weight index in healthy female domestic pigs
Estimation of normal lung weight index in healthy female domestic pigs Open
View article: Causes of Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome: A Combined Multiple Inert Gas Elimination Technique and Dual-energy Computed Tomography Study
Causes of Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome: A Combined Multiple Inert Gas Elimination Technique and Dual-energy Computed Tomography Study Open
Background: Despite the fervent scientific effort, a state-of-the art assessment of the different causes of hypoxemia (shunt, ventilation–perfusion mismatch, and diffusion limitation) in COVID-19 acute respiratory distress syndrome (ARDS) …
View article: Editorial: The Pulmonary and extra-pulmonary effects of mechanical ventilation in critically-ill patients
Editorial: The Pulmonary and extra-pulmonary effects of mechanical ventilation in critically-ill patients Open
EDITORIAL article Front. Med., 18 August 2023Sec. Pulmonary Medicine Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1272322
View article: Gas volume corrections in intensive care unit: needed or pointless?
Gas volume corrections in intensive care unit: needed or pointless? Open
Gas volume conditions are often ignored or unknown in the clinical practice. However, they could have relevance for the calculation of some key variables in ICU setting. This study shows that gas volume corrections are mostly relevant when…
View article: Specific Respiratory System Compliance in COVID-19 and Non–COVID-19 Acute Respiratory Distress Syndrome
Specific Respiratory System Compliance in COVID-19 and Non–COVID-19 Acute Respiratory Distress Syndrome Open
"Specific Respiratory System Compliance in COVID-19 and Non COVID-19 ARDS." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Relationship between D-dimers and dead-space on disease severity and mortality in COVID-19 acute respiratory distress syndrome: A retrospective observational cohort study
Relationship between D-dimers and dead-space on disease severity and mortality in COVID-19 acute respiratory distress syndrome: A retrospective observational cohort study Open
We report no association between dead space and inflammatory markers in mechanically ventilated patients with C-ARDS. Our results support theories suggesting that multiple mechanisms, in addition to immunothrombosis, play a role in the pat…
View article: Prone position: how understanding and clinical application of a technique progress with time
Prone position: how understanding and clinical application of a technique progress with time Open
Historical background The prone position was first proposed on theoretical background in 1974 (more advantageous distribution of mechanical ventilation). The first clinical report on 5 ARDS patients in 1976 showed remarkable improvement of…
View article: High- versus Low-Flow Extracorporeal Respiratory Support in Experimental Hypoxemic Acute Lung Injury
High- versus Low-Flow Extracorporeal Respiratory Support in Experimental Hypoxemic Acute Lung Injury Open
Rationale: In the EOLIA (ECMO to Rescue Lung Injury in Severe ARDS) trial, oxygenation was similar between intervention and conventional groups, whereas [Formula: see text]e was reduced in the intervention group. Comparable reductio…
View article: Relationship between D-Dimers and Dead-Space on Disease Severity and Mortality in Covid-19 Acute Respiratory Distress Syndrome: A Retrospective Observational Cohort Study
Relationship between D-Dimers and Dead-Space on Disease Severity and Mortality in Covid-19 Acute Respiratory Distress Syndrome: A Retrospective Observational Cohort Study Open
View article: Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome
Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome Open
View article: Biochemical shunt: where and how?
Biochemical shunt: where and how? Open
Response to Harutyunyan et al. “Hypoxaemia in the early stage of COVID-19: prevalence of physical or biochemical factors?” https://bit.ly/3K1NSKu
View article: Hypoxaemia in COVID-19: many pieces to a complex puzzle
Hypoxaemia in COVID-19: many pieces to a complex puzzle Open
Hypoxaemia from COVID-19 is likely a consequence of multiple causes https://bit.ly/3yXCJGZ
View article: End-Tidal to Arterial P<scp>co</scp><sub>2</sub> Ratio as Guide to Weaning from Venovenous Extracorporeal Membrane Oxygenation
End-Tidal to Arterial P<span>co</span><sub>2</sub> Ratio as Guide to Weaning from Venovenous Extracorporeal Membrane Oxygenation Open
Rationale: Weaning from venovenous extracorporeal membrane oxygenation (VV-ECMO) is based on oxygenation and not on carbon dioxide elimination. Objectives: To predict readiness to wean from VV-ECMO. Methods: In this mu…
View article: Dataset related to the article "Prevalence and outcome of silent hypoxemia in COVID-19"
Dataset related to the article "Prevalence and outcome of silent hypoxemia in COVID-19" Open
Dataset related to the article "Prevalence and outcome of silent hypoxemia in COVID-19" Abstract Background: In the early stages of COVID-19 pneumonia, hypoxemia has been described in absence of d…
View article: Dataset related to the article "Prevalence and outcome of silent hypoxemia in COVID-19"
Dataset related to the article "Prevalence and outcome of silent hypoxemia in COVID-19" Open
Dataset related to the article "Prevalence and outcome of silent hypoxemia in COVID-19" Abstract Background: In the early stages of COVID-19 pneumonia, hypoxemia has been described in absence of d…
View article: Mechanical power thresholds during mechanical ventilation: An experimental study
Mechanical power thresholds during mechanical ventilation: An experimental study Open
The extent of ventilator-induced lung injury may be related to the intensity of mechanical ventilation--expressed as mechanical power. In the present study, we investigated whether there is a safe threshold, below which lung damage is abse…
View article: Correction to: Role of total lung stress on the progression of early COVID‑19 pneumonia
Correction to: Role of total lung stress on the progression of early COVID‑19 pneumonia Open
View article: Orthodeoxia and its implications on awake-proning in COVID-19 pneumonia
Orthodeoxia and its implications on awake-proning in COVID-19 pneumonia Open
View article: Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia
Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia Open
The amount of consolidated tissue was higher in patients assessed during the third week and determined the oxygenation responses following pronation and recruitment maneuvers.