Mattia Privitera
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View article: GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice
GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice Open
Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and automated cage-side monitoring tool for mi…
View article: Analysis of behavioral flow resolves latent phenotypes
Analysis of behavioral flow resolves latent phenotypes Open
View article: Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy
Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy Open
Noradrenaline (NA) release from the locus coeruleus (LC) changes activity and connectivity in neuronal networks across the brain, modulating multiple behavioral states. NA release is mediated by both tonic and burst-like LC activity. Howev…
View article: Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus
Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus Open
Information seeking, such as standing on tiptoes to look around in humans, is observed across animals and helps survival. Its rodent analog—unsupported rearing on hind legs—was a classic model in deciphering neural signals of cognition and…
View article: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we combine RNA sequencing with…
View article: Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Methods Data availability References Article and author information Abstract Exposure to an acute stressor triggers a complex cas…
View article: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Reviewer #2 (Public Review): Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Reviewer #2 (Public Review): Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Harnessing PROTAC technology to combat stress hormone receptor activation
Harnessing PROTAC technology to combat stress hormone receptor activation Open
View article: Analysis of behavioral flow resolves latent phenotypes
Analysis of behavioral flow resolves latent phenotypes Open
Preclinical biomedical research depends on accurately detecting and quantifying rodent behavior. Current data-driven approaches, which segment free exploratory behavior into clusters, suffer from low statistical power due to multiple-testi…
View article: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we combine RNA sequencing with…
View article: Analysis of behavioral flow resolves latent phenotypes
Analysis of behavioral flow resolves latent phenotypes Open
The nuanced detection of rodent behavior in preclinical biomedical research is essential for understanding disease conditions, genetic phenotypes, and internal states. Recent advances in machine vision and artificial intelligence have popu…
View article: Exploratory rearing is governed by hypothalamic MCH cells according to the locus coeruleus
Exploratory rearing is governed by hypothalamic MCH cells according to the locus coeruleus Open
Exploration is essential for survival because it allows animals to gather information about their environment. Rearing is a classic exploratory behavior, during which an animal transiently stands on its hind legs to sample its environment.…
View article: Harnessing PROTAC technology to combat stress hormone receptor activation
Harnessing PROTAC technology to combat stress hormone receptor activation Open
Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectivity and induces unwanted side effects. To …
View article: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Multiomic profiling of the acute stress response in the mouse hippocampus
Multiomic profiling of the acute stress response in the mouse hippocampus Open
The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief swim exposure to trigger an acute stress response in mice, wh…
View article: Chronic adolescent stress increases exploratory behavior but does not appear to change the acute stress response in adult male C57BL/6 mice
Chronic adolescent stress increases exploratory behavior but does not appear to change the acute stress response in adult male C57BL/6 mice Open
Chronic stress exposure in adolescence can lead to a lasting change in stress responsiveness later in life and is associated with increased mental health issues in adulthood. Here we investigate whether the Chronic Social Instability (CSI)…
View article: Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice
Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice Open
Chronic stress exposure in adolescence can lead to a lasting change in stress responsiveness later in life and is associated with increased mental health issues in adulthood. Here we investigate whether the Chronic Social Instability (CSI)…
View article: Molecular roadmap of the healthy stress response in the mouse hippocampus
Molecular roadmap of the healthy stress response in the mouse hippocampus Open
Summary The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, little is known about the nature and dynamics of the underlying molecular cascades. We used a brief forced swim exposure …
View article: Author Correction: A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents
Author Correction: A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents Open
View article: Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions
Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions Open
View article: A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents
A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents Open
View article: DeepLabCut network for pupillometry analysis (Privitera et al. 2020)
DeepLabCut network for pupillometry analysis (Privitera et al. 2020) Open
Network trained for Privitera et al. 2020. Used for the analysis of pupillometry video files using an infrared camera and anesthetized mice
View article: DeepLabCut network for pupillometry analysis (Privitera et al. 2020)
DeepLabCut network for pupillometry analysis (Privitera et al. 2020) Open
Network trained for Privitera et al. 2020. Used for the analysis of pupillometry video files using an infrared camera and anesthetized mice
View article: Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation
Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation Open
View article: Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation
Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation Open
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain, regulates many fundamental brain functions, and is implicated in several neuropsychiatric diseases. Although selective manipulation of the LC is not possible in…
View article: Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation
Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation Open
View article: Distinct Proteomic, Transcriptomic, and Epigenetic Stress Responses in Dorsal and Ventral Hippocampus
Distinct Proteomic, Transcriptomic, and Epigenetic Stress Responses in Dorsal and Ventral Hippocampus Open