Mattias Svensson
YOU?
Author Swipe
View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inter…
View article: Alpha-toxin-elicited CX <sub>3</sub> CL1 release in <i>Staphylococcus aureus</i> pneumonia impairs bactericidal function of human monocytes
Alpha-toxin-elicited CX <sub>3</sub> CL1 release in <i>Staphylococcus aureus</i> pneumonia impairs bactericidal function of human monocytes Open
Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin. In this study, w…
View article: Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort
Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort Open
View article: Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer
Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer Open
Background: Knowledge discovery in databases (KDD) can contribute to translational research, also known as translational medicine, by bridging the gap between in vitro and in vivo studies, and clinical applications. Here, we propose a ‘sys…
View article: Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge
Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge Open
Degradation of immunoglobulin (Ig) represents an important bacterial immune evasion strategy. For mucosal colonization, degradation of IgA is of particular importance, and many bacteria secrete specific IgA proteases that typically target …
View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococci (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their intera…
View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inter…
View article: Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
View article: Knowledge Discovery in Datasets of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer
Knowledge Discovery in Datasets of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer Open
Knowledge discovery in databases (KDD) can contribute to translational research, also known as translational medicine, by bridging the gap between in vitro and in vivo studies and clinical applications. Here, we propose a ‘systems modeling…
View article: Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10–15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based sys…
View article: Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients
Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients Open
Objectives Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents at the emergency d…
View article: Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes , or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inte…
View article: The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19
The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19 Open
View article: A validated model for early prediction of group A streptococcal aetiology and clinical endpoints in necrotising soft tissue infections
A validated model for early prediction of group A streptococcal aetiology and clinical endpoints in necrotising soft tissue infections Open
Objectives To develop and externally validate machine learning models for predicting microbial aetiology and clinical endpoints, encompassing surgery, patient management, and organ support in Necrotising Soft Tissue Infections (NSTI). Meth…
View article: Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19 Open
Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (…
View article: Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes
Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes Open
Background Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat and skin to severe invasive infections, such as necrotizing soft tissue infections (NSTIs). …
View article: Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF
Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF Open
View article: Antibiotics against Pseudomonas aeruginosa on Human Skin Cell Lines: Determination of the Highest Non-Cytotoxic Concentrations with Antibiofilm Capacity for Wound Healing Strategies
Antibiotics against Pseudomonas aeruginosa on Human Skin Cell Lines: Determination of the Highest Non-Cytotoxic Concentrations with Antibiofilm Capacity for Wound Healing Strategies Open
Pseudomonas aeruginosa is one of the most common microorganisms causing infections of severe skin wounds. Antibiotic or antiseptic treatments are crucial to prevent and curb these infections. Antiseptics have been reported to be cytotoxic …
View article: Alpha-toxin elicited CX<sub>3</sub>CL1-release via ADAM10 in<i>Staphylococcus aureus</i>pneumonia impairs bactericidal function of human monocytes
Alpha-toxin elicited CX<sub>3</sub>CL1-release via ADAM10 in<i>Staphylococcus aureus</i>pneumonia impairs bactericidal function of human monocytes Open
Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming alpha-toxin. In this stud…
View article: Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes Open
View article: Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability Open
Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes infection is reg…
View article: The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis Open
Innate lymphoid cells (ILCs) are considered innate counterparts of adaptive T cells; however, their common and unique transcriptional signatures in pediatric inflammatory bowel disease (pIBD) are largely unknown. Here, we report a dysregul…
View article: Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells
Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells Open
Langerhans cell histiocytosis (LCH) is a potentially life-threatening inflammatory myeloid neoplasia linked to paediatric neurodegeneration, whereby transformed LCH cells form agglomerated lesions in various organs. Although MAP-kinase pat…
View article: Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study
Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study Open
Several inflammatory mediators and wider profiles were identified as potential biomarkers of NSTI. Associations of biomarker levels to type of infection and outcomes may be utilized to improve patient care and outcomes.
View article: Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia Open
Background COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the patho…
View article: Additional file 2 of Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
Additional file 2 of Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes Open
Additional file 2. Tables S1-S6.
View article: The Karolinska <scp>KI</scp>/K <scp>COVID</scp>‐19 immune atlas: An open resource for immunological research and educational purposes
The Karolinska <span>KI</span>/K <span>COVID</span>‐19 immune atlas: An open resource for immunological research and educational purposes Open
The Karolinska KI/K COVID‐19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS‐CoV‐2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immun…
View article: Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections Open
Abstract Background Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial infectio…
View article: Immunosuppressive Features of the Microenvironment in Lymph Nodes Granulomas from Tuberculosis and HIV–Co-Infected Patients
Immunosuppressive Features of the Microenvironment in Lymph Nodes Granulomas from Tuberculosis and HIV–Co-Infected Patients Open
Tuberculosis (TB) and HIV co-infection claims many lives every year. This study assessed immune responses in Mycobacterium tuberculosis-infected lymph node tissues from HIV-negative and HIV-positive patients compared with the peripheral ci…
View article: COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations
COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations Open
Corona disease 2019 (COVID‐19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID‐19 severity. However, several questions pertain with respect to the metabolome in COVI…