Matylda Roszkowska
YOU?
Author Swipe
View article: Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity
Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity Open
Background Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post - translational lipid modification, modulates synaptic pro…
View article: Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity
Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity Open
S-palmitoylation, a dynamic post-translational modification, has long been suggested to play a pivotal role in synaptic plasticity, learning, and memory. However, its precise impact on synaptic proteins and function remains unclear. In thi…
View article: Stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses
Stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses Open
Stress resilience is the ability of neuronal networks to maintain their function despite the stress exposure. Using a mouse model we investigate stress resilience phenomenon. To assess the resilient and anhedonic behavioral phenotypes deve…
View article: Stress Resilience is an Active and Multifactorial Process Manifested by Structural, Functional, and Molecular Changes in Synapses
Stress Resilience is an Active and Multifactorial Process Manifested by Structural, Functional, and Molecular Changes in Synapses Open
View article: Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice
Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice Open
Clinical and preclinical studies show evidence that chronic stress or nutritional deficits in dietary zinc (Zn) intake may be risk factors for developing major depressive disorder (MDD). Furthermore, there may be possible links between low…
View article: The molecular fingerprint of stress resilience
The molecular fingerprint of stress resilience Open
Stress resilience is an ability of neuronal networks to maintain their function despite the stress exposure. In this study, we investigate whether stress resilience is an actively developed dynamic process in adult mice. In order to assess…
View article: SRF depletion in early life contributes to social interaction deficits in the adulthood
SRF depletion in early life contributes to social interaction deficits in the adulthood Open
Alterations in social behavior are core symptoms of major developmental neuropsychiatric diseases such as autism spectrum disorders or schizophrenia. Hence, understanding their molecular and cellular underpinnings constitutes the major res…
View article: Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior
Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior Open
Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity that may be caused by abnormal serotonergic signaling. Using a combination of behavioral, biochemical, and imaging methods, we analyze 5-HT7R/MMP-9 …
View article: S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity
S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity Open
Although sex differences in the brain are prevalent, the knowledge about mechanisms underlying sex-related effects on normal and pathological brain functioning is rather poor. It is known that female and male brains differ in size and conn…
View article: Serum response factor is essential for synaptic maturation in the hippocampus
Serum response factor is essential for synaptic maturation in the hippocampus Open
Disturbances of gene expression patterns that occur during brain development can severely affect signal transmission, connectivity, and plasticity—key features that underlie memory formation and storage in neurons. Abnormalities at the mol…
View article: Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus
Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus Open
Ketamine is an N-methyl-d-aspartate receptor antagonist that has gained wide attention as a potent antidepressant. It has also been recently reported to have prophylactic effects in animal models of depression and anxiety. Alterations of n…
View article: Author Correction: Quantitative 3-D morphometric analysis of individual dendritic spines
Author Correction: Quantitative 3-D morphometric analysis of individual dendritic spines Open
View article: A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect
A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect Open
View article: Quantitative 3-D morphometric analysis of individual dendritic spines
Quantitative 3-D morphometric analysis of individual dendritic spines Open
The observation and analysis of dendritic spines morphological changes poses a major challenge in neuroscience studies. The alterations of their density and/or morphology are indicators of the cellular processes involved in neural plastici…
View article: Computational Approach to Dendritic Spine Taxonomy and Shape Transition Analysis
Computational Approach to Dendritic Spine Taxonomy and Shape Transition Analysis Open
View article: Different Doublecortin (DCX) Patient Alleles Show Distinct Phenotypes in Cultured Neurons
Different Doublecortin (DCX) Patient Alleles Show Distinct Phenotypes in Cultured Neurons Open
Doublecortin on the X-chromosome (DCX) is a neuronal microtubule-binding protein with a multitude of roles in neurodevelopment. In humans, DCX is a major genetic locus for X-linked lissencephaly. The best studied defects are in neuronal mi…
View article: CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines
CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines Open
Synaptic cell adhesion molecules regulate signal transduction, synaptic function, and plasticity. However, their role in neuronal interactions with the extracellular matrix (ECM) is not well understood. Here we report that the CD44, a tran…
View article: Computational approach to dendritic spine taxonomy and shape transition analysis
Computational approach to dendritic spine taxonomy and shape transition analysis Open
The common approach in morphological analysis of dendritic spines is to categorize spines into subpopulations based on whether they are stubby, mushroom, thin, or filopodia. Corresponding cellular models of synaptic plasticity, long-term p…