Maud Kamal
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View article: Scandare: A Successful, Flexible, Prospective, and Longitudinal Biobank Framework
Scandare: A Successful, Flexible, Prospective, and Longitudinal Biobank Framework Open
Patient-specific tumor heterogeneity is a significant challenge to understanding and treating cancer. The availability of multi-omic data in large public repositories has powered breakthroughs in precision medicine by enabling diversified …
View article: Prevalence of Molecular Mutations in Non–Small Cell Lung Cancer and Current Treatment Approaches in the MENA Region: Systematic Review and Expert Opinion
Prevalence of Molecular Mutations in Non–Small Cell Lung Cancer and Current Treatment Approaches in the MENA Region: Systematic Review and Expert Opinion Open
Over the past decade, the discovery of immunotherapy and targeted therapy has set new standards for the management of advanced non–small cell lung cancer (NSCLC). This study aims to investigate the prevalence of ALK, EGFR, KRAS, ROS1, MET,…
View article: Efficacy of pembrolizumab and vorinostat combination in patients with recurrent and/or metastatic squamous cell carcinomas: a phase 2 basket trial
Efficacy of pembrolizumab and vorinostat combination in patients with recurrent and/or metastatic squamous cell carcinomas: a phase 2 basket trial Open
View article: Symptomatic Urinary Tract Infection Following Single-Dose Prophylactic Antibiotic Administration in Patients Undergoing Cystoscopic DJ Stent Removal
Symptomatic Urinary Tract Infection Following Single-Dose Prophylactic Antibiotic Administration in Patients Undergoing Cystoscopic DJ Stent Removal Open
Background: Symptomatic urinary tract infection (UTI) is a known complication following cystoscopic double-J (DJ) stent removal, often mitigated with prophylactic antibiotics. However, the necessity and efficacy of single-dose antibiotic p…
View article: Real-world performance analysis of a universal computational reasoning model for precision oncology in lung cancer
Real-world performance analysis of a universal computational reasoning model for precision oncology in lung cancer Open
View article: Development and implementation of novel liquid biopsy NGS panels via the OncNGS precommercial procurement (PCP) initiative
Development and implementation of novel liquid biopsy NGS panels via the OncNGS precommercial procurement (PCP) initiative Open
By leveraging the PCP approach, OncNGS aims to deliver innovative, affordable solutions to standardize ctDNA testing and reporting across European Union countries, improving diagnostic and therapeutic strategies for oncology patients.
View article: Efficacy of Super Oxidized Solution Versus Povidone Iodine in the Management of Diabetic Foot Ulcers
Efficacy of Super Oxidized Solution Versus Povidone Iodine in the Management of Diabetic Foot Ulcers Open
Background: Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, frequently leading to infection, prolonged hospitalization, and amputation. Despite widespread use, conventional antiseptics like povidone iodine may im…
View article: A decalogue of Molecular Tumor Board (MTB) recommendations from the CAN.HEAL Consortium
A decalogue of Molecular Tumor Board (MTB) recommendations from the CAN.HEAL Consortium Open
Standardizing MTB practices represents a key step toward equitable access to personalized medicine and improved cancer care across Europe. Sustainable implementation requires coordinated EU efforts, and dynamic MTBs that continuously refin…
View article: Supplementary Tables S1-S22 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Tables S1-S22 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Table S1. Targeted bisulfite sequencing primers Table S2. Target copies and CpG sites relative to the number of sequencing reads Table S3. Statistical results of global methylation differences between healthy samples and cancer subgroups u…
View article: Supplementary Figure S5 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S5 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S5. Comparison of tumor and plasma paired samples
View article: Supplementary Figure S7 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S7 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S7. Extraction of L1PA DNA hypomethylation signal from whole genome data
View article: Supplementary Figure S6 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S6 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S6. Classifier performances: feature types, calculation parameters, cancer subtypes and stages
View article: Supplementary Figure S7 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S7 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S7. Extraction of L1PA DNA hypomethylation signal from whole genome data
View article: Supplementary Figure S2 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S2 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S2. Methylation profiles obtained with bisulfite or enzymatic conversion are similar
View article: Supplementary Figure S6 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S6 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S6. Classifier performances: feature types, calculation parameters, cancer subtypes and stages
View article: Supplementary Figure S11 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S11 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S11. 2 step-models integrating CNA signal extracted from DIAMOND data
View article: Supplementary Figure S8 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S8 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S8. DIAMOND profiles and performances in the validation versus discovery cohorts
View article: Supplementary Figure S8 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S8 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S8. DIAMOND profiles and performances in the validation versus discovery cohorts
View article: Supplementary Tables S1-S22 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Tables S1-S22 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Table S1. Targeted bisulfite sequencing primers Table S2. Target copies and CpG sites relative to the number of sequencing reads Table S3. Statistical results of global methylation differences between healthy samples and cancer subgroups u…
View article: Supplementary Figure S9 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S9 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S9. Age has a minor effect on L1PA DNA methylation patterns and is not a confounding factor in this study
View article: Supplementary Figure S3 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S3 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S3. Preparation of L1PA targeted bisulfite sequencing libraries and analysis workflow
View article: Supplementary Figure S4 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S4 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S4. DIAMOND features: CpG calling and contribution of CG positions or haplotypes
View article: Supplementary Figure S3 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S3 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S3. Preparation of L1PA targeted bisulfite sequencing libraries and analysis workflow
View article: Data from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Data from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Purpose:The detection of ctDNA, which allows noninvasive tumor molecular profiling and disease follow-up, promises optimal and individualized management of patients with cancer. However, detecting small fractions of tumor DNA released when…
View article: Supplementary Figure S5 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S5 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S5. Comparison of tumor and plasma paired samples
View article: Supplementary Figure S2 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S2 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S2. Methylation profiles obtained with bisulfite or enzymatic conversion are similar
View article: Supplementary Figure S11 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S11 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S11. 2 step-models integrating CNA signal extracted from DIAMOND data
View article: Supplementary Figure S1 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S1 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S1. cfDNA extraction methods did not impact the L1PA methylation patterns
View article: Supplementary Figure S4 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S4 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S4. DIAMOND features: CpG calling and contribution of CG positions or haplotypes
View article: Supplementary Figure S10 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
Supplementary Figure S10 from Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons Open
Fig S10. Comparison of multiple classifiers (expert, all, stack and blind models) and prognostic value of L1PA hypomethylation