Maud Racapé
YOU?
Author Swipe
View article: #2586 Urinary and blood mRNA biomarkers for detecting kidney allograft rejection (The KTD-Innov study: NCT03582436)
#2586 Urinary and blood mRNA biomarkers for detecting kidney allograft rejection (The KTD-Innov study: NCT03582436) Open
Background and Aims Blood and urinary mRNA biomarkers are non-invasive tools with potential for detecting kidney allograft rejection. However, their ability to provide added diagnostic value beyond current standard-of-care (SOC) patient mo…
View article: #1503 Detection of kidney allograft rejection using urinary chemokines: a prospective multicenter cohort study (KTD-Innov)
#1503 Detection of kidney allograft rejection using urinary chemokines: a prospective multicenter cohort study (KTD-Innov) Open
Background and Aims Urinary chemokines CXCL9 and CXCL10 have shown promise for detecting kidney allograft rejection, but the demonstration of their added value beyond standard of care patient monitoring requires further study. Method We pr…
View article: Evaluation of a Decentralized Donor-Derived Cell-Free DNA Assay for Kidney Allograft Rejection Monitoring
Evaluation of a Decentralized Donor-Derived Cell-Free DNA Assay for Kidney Allograft Rejection Monitoring Open
Donor-derived cell-free DNA (dd-cfDNA) is an emerging non-invasive biomarker for allograft injury detection. This study aimed to evaluate a new, decentralized dd-cfDNA testing kit against a centralized dd-cfDNA testing service broadly util…
View article: Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)
Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN) Open
Non-invasive biomarkers are promising tools for improving kidney allograft rejection monitoring, but their clinical adoption requires more evidence in specifically designed studies. To address this unmet need, we designed the EU-TRAIN stud…
View article: Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies
Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies Open
Recently, interest in transcriptomic assessment of kidney biopsies has been growing. This study investigates the use of NGS to identify gene expression changes and analyse the pathways involved in rejection. An Illumina bulk RNA sequencing…
View article: Cell-free DNA for the detection of kidney allograft rejection
Cell-free DNA for the detection of kidney allograft rejection Open
View article: Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection Open
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipie…
View article: Validation of the clinical utility of microRNA as noninvasive biomarkers of cardiac allograft rejection: A prospective longitudinal multicenter study
Validation of the clinical utility of microRNA as noninvasive biomarkers of cardiac allograft rejection: A prospective longitudinal multicenter study Open
View article: #2683 NEXT GENERATION SEQUENCING: FROM BANFF SCORE MOLECULAR SIGNATURES AND CLASSIFIERS TO PREDICTED HISTOLOGICAL ARCHETYPES OF KIDNEY BIOPSIES
#2683 NEXT GENERATION SEQUENCING: FROM BANFF SCORE MOLECULAR SIGNATURES AND CLASSIFIERS TO PREDICTED HISTOLOGICAL ARCHETYPES OF KIDNEY BIOPSIES Open
Background and Aims To improve risk stratification in kidney transplantation, molecular diagnostic tools are increasingly investigated for their feasibility and gain in diagnostic power. Nonetheless, previously published studies focused on…
View article: #3743 MULTIDIMENSIONAL RISK ASSESSMENT OF KIDNEY ALLOGRAFT REJECTION USING DONOR DERIVED CELL-FREE DNA
#3743 MULTIDIMENSIONAL RISK ASSESSMENT OF KIDNEY ALLOGRAFT REJECTION USING DONOR DERIVED CELL-FREE DNA Open
Background and Aims Post-transplantation patient care requires development and validation of non-invasive biomarkers to improve allograft monitoring and prevention from unnecessary and costly biopsies. Reports have suggested the associatio…
View article: Determinants of sudden cardiac death after heart transplantation
Determinants of sudden cardiac death after heart transplantation Open
Background Heart transplant recipients are at high-risk of sudden cardiac death (SCD). However, risk factors of SCD in heart recipients remained poorly described. Objective To assess the predictors of SCD beyond the first-year post-transpl…
View article: Incidence of sudden cardiac death after heart transplantation
Incidence of sudden cardiac death after heart transplantation Open
Background Sudden cardiac death (SCD) is a major contributor to the rate of mortality after heart transplantation. However, little is known about the incidence of SCD in heart recipients. Objective To assess the incidence of SCD after hear…
View article: Identification and Characterization of Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation
Identification and Characterization of Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation Open
Background: Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient mortality. Little is known about the prototypes of CAV trajectories at the population level. We aimed to identify the different evolution…
View article: Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants Open
View article: 3399Determinants and outcomes of cardiac allograft vasculopathy: major role of donor specific antibody
3399Determinants and outcomes of cardiac allograft vasculopathy: major role of donor specific antibody Open
Background: Neutrophils are able to release their nuclear content into extracellular space by formation of neutrophil extracellular traps (NETs).NETs neutralize pathogens, but have also been implicated in autoimmune and thrombotic diseases…
View article: Antibody-mediated rejection in pediatric small bowel transplantation: Capillaritis is a major determinant of C4d positivity in intestinal transplant biopsies
Antibody-mediated rejection in pediatric small bowel transplantation: Capillaritis is a major determinant of C4d positivity in intestinal transplant biopsies Open
View article: Relatedness of Antibodies to Peptides Containing Homocitrulline or Citrulline in Patients with Rheumatoid Arthritis
Relatedness of Antibodies to Peptides Containing Homocitrulline or Citrulline in Patients with Rheumatoid Arthritis Open
Objective. Antibodies that target citrullinated protein/peptide (ACPA) and homocitrullinated/carbamylated protein/peptide (AHCPA) are associated with rheumatoid arthritis (RA). The relationship between ACPA and AHCPA remains unclear. We ex…
View article: Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection
Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection Open
Humoral rejection is the most common cause of solid organ transplant failure. Here, we evaluated a cohort of 49 patients who were successfully grafted with allogenic islets and determined that the appearance of donor-specific anti-HLA anti…
View article: Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection
Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection Open
Background: Antibody-mediated rejection (AMR) contributes to heart allograft loss. However, an important knowledge gap remains in terms of the pathophysiology of AMR and how detection of immune activity, injury degree, and stage could be i…
View article: Molecular Assessment of Microcirculation Injury in Formalin-Fixed Human Cardiac Allograft Biopsies With Antibody-Mediated Rejection
Molecular Assessment of Microcirculation Injury in Formalin-Fixed Human Cardiac Allograft Biopsies With Antibody-Mediated Rejection Open
Precise diagnosis of antibody-mediated rejection (AMR) in cardiac allograft endomyocardial biopsies (EMBs) remains challenging. This study assessed molecular diagnostics in human EMBs with AMR. A set of 34 endothelial, natural killer cell …
View article: Molecular Correlates of Endothelial mTOR Activation in Heart Transplant Recipients
Molecular Correlates of Endothelial mTOR Activation in Heart Transplant Recipients Open