Maud Wilhelm
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View article: Donor Variability and PD-1 Expression Limit BK Polyomavirus-specific T-cell Function and Therapy
Donor Variability and PD-1 Expression Limit BK Polyomavirus-specific T-cell Function and Therapy Open
Background. BK polyomavirus (BKPyV) nephropathy is a major cause of premature kidney transplant failure. Current management relies on reducing immunosuppression to restore BKPyV-specific immune control. Ex vivo expansion and transfer of BK…
View article: BK polyomavirus serotype-specific antibody responses in blood donors and kidney transplant recipients with and without new-onset BK polyomavirus-DNAemia: A Swiss Transplant Cohort Study
BK polyomavirus serotype-specific antibody responses in blood donors and kidney transplant recipients with and without new-onset BK polyomavirus-DNAemia: A Swiss Transplant Cohort Study Open
View article: Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study
Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study Open
BK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing…
View article: P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice
P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice Open
In systemic lupus erythematosus, T cells display multiple abnormalities. They are abnormally activated, secrete pro-inflammatory cytokines, help B cells to generate pathogenic autoantibodies, and provoke the accumulation of autoreactive me…
View article: Implication of a lysosomal antigen in the pathogenesis of lupus erythematosus
Implication of a lysosomal antigen in the pathogenesis of lupus erythematosus Open
View article: Variations in BK Polyomavirus Immunodominant Large Tumor Antigen-Specific 9mer CD8 T-Cell Epitopes Predict Altered HLA-Presentation and Immune Failure
Variations in BK Polyomavirus Immunodominant Large Tumor Antigen-Specific 9mer CD8 T-Cell Epitopes Predict Altered HLA-Presentation and Immune Failure Open
Failing BK polyomavirus (BKPyV)-specific immune control is underlying onset and duration of BKPyV-replication and disease. We focused on BKPyV-specific CD8 T-cells as key effectors and characterized immunodominant 9mer epitopes in the vira…
View article: BK Polyomavirus–Specific CD8 T-Cell Expansion In Vitro Using 27mer Peptide Antigens for Developing Adoptive T-Cell Transfer and Vaccination
BK Polyomavirus–Specific CD8 T-Cell Expansion In Vitro Using 27mer Peptide Antigens for Developing Adoptive T-Cell Transfer and Vaccination Open
Background BK polyomavirus (BKPyV) remains a significant cause of premature kidney transplant failure. In the absence of effective antivirals, current treatments rely on reducing immunosuppression to regain immune control over BKPyV replic…
View article: Assessing Autophagy in Mouse Models and Patients with Systemic Autoimmune Diseases
Assessing Autophagy in Mouse Models and Patients with Systemic Autoimmune Diseases Open
Autophagy is a tightly regulated mechanism that allows cells to renew themselves through the lysosomal degradation of proteins, which are misfolded or produced in excess, and of damaged organelles. In the context of immunity, recent resear…
View article: Etude du mécanisme d'action chez l'homme d'un peptide immunomodulateur de la maladie lupique
Etude du mécanisme d'action chez l'homme d'un peptide immunomodulateur de la maladie lupique Open
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease triggered by genetic, hormonal and environmental factors. It is mainly characterized by the presence of autoantibodies directed against nuclear elements. Most of current t…
View article: Study ot the mechanism of action in humans of an immunomodulator of lupus disease
Study ot the mechanism of action in humans of an immunomodulator of lupus disease Open
Le lupus érythémateux disséminé est une maladie autoimmune systémique déclenchée par une combinaison de facteurs génétiques, hormonaux et environnementaux. Il se caractérise notamment par la présence d’autoanticorps dirigés principalement …