Iván Martín
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View article: An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell‐Based Grafts
An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell‐Based Grafts Open
Introduction Cell therapies for painful intervertebral disc (IVD) degeneration (IDD) have not yet achieved widespread clinical adoption. Understanding therapeutic cell effects in native IVD remains challenging due to the complex IVD enviro…
View article: Dual-Lineage Human 3D Bone Niche Model Reveals Osteoclast-Driven Osteomimicry in Prostate Cancer
Dual-Lineage Human 3D Bone Niche Model Reveals Osteoclast-Driven Osteomimicry in Prostate Cancer Open
Bone is the predominant site of metastasis in advanced prostate cancer (PCa), yet the mechanisms governing tumor-bone interactions remain incompletely understood. A modular human three-dimensional (3D) in vitro bone niche model is develope…
View article: Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids
Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids Open
Endosteal bone marrow (BM) niches are crucial to sustain non-steady-state hematopoiesis but are challenging to be modeled in their cellular and molecular complexity in standardized, human settings. We report a developmentally guided approa…
View article: Fibronectin- and Bioactive Glass-Modified Alginate Scaffolds Support Limited Primary Cell Proliferation In Vitro yet Demonstrate Effective Host Integration In Vivo
Fibronectin- and Bioactive Glass-Modified Alginate Scaffolds Support Limited Primary Cell Proliferation In Vitro yet Demonstrate Effective Host Integration In Vivo Open
Alginate-hydroxyapatite (AL) scaffolds modified with fibronectin (FN) or bioactive glass (BGMS10) have recently been characterized for their physicochemical properties and proposed as promising candidates for bone regeneration. Here, we pr…
View article: Fibronectin- and Bioactive Glass-Modified Alginate Scaffolds Support Limited Primary Cell Proliferation In Vitro yet Demonstrate Effective Host Integration In Vivo
Fibronectin- and Bioactive Glass-Modified Alginate Scaffolds Support Limited Primary Cell Proliferation In Vitro yet Demonstrate Effective Host Integration In Vivo Open
Alginate-hydroxyapatite (AL) scaffolds modified with fibronectin (FN), or bioactive glass (BGMS10) have recently been characterized for their physicochemical properties and proposed as promising candidates for bone regeneration. Here, we p…
View article: Treatment of patellofemoral osteoarthritis with nasal chondrocyte-based engineered cartilage implantation in a randomised, controlled, multicentre phase II clinical trial: protocol for a randomised controlled trial
Treatment of patellofemoral osteoarthritis with nasal chondrocyte-based engineered cartilage implantation in a randomised, controlled, multicentre phase II clinical trial: protocol for a randomised controlled trial Open
Introduction Knee osteoarthritis often starts in the patellofemoral compartment of the knee and is diagnosed in about 39% of people with knee pain aged above 30 years. Patellofemoral osteoarthritis plays a crucial role in the reduction of …
View article: An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis
An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis Open
Altered joint loading due to articular malalignment, instability, or trauma is an important risk factor for osteoarthritis (OA), the most prevalent musculoskeletal disease worldwide. However, the molecular links between aberrant mechanics …
View article: Evaluation of thermoresponsive biopolymers-based composite bioinks for cartilage engineering
Evaluation of thermoresponsive biopolymers-based composite bioinks for cartilage engineering Open
View article: Perfusion-based ex vivo culture of frozen ovarian cancer tissues with preserved tumor microenvironment
Perfusion-based ex vivo culture of frozen ovarian cancer tissues with preserved tumor microenvironment Open
View article: Incorporation of Cross-Linked Gelatin Microparticles To Enhance Cell Attachment and Chondrogenesis in Carboxylated Agarose Bioinks for Cartilage Engineering
Incorporation of Cross-Linked Gelatin Microparticles To Enhance Cell Attachment and Chondrogenesis in Carboxylated Agarose Bioinks for Cartilage Engineering Open
Due to the limited regenerative capacity of injured cartilage, surgical intervention using engineered cellular constructs or autologous cell implantation is the best accredited approach to prevent further degeneration and promote a regener…
View article: Challenges of engineering a functional growth plate in vitro
Challenges of engineering a functional growth plate in vitro Open
Several cartilage and bone organoids have been developed in vitro and in vivo using adult mesenchymal stromal/stem cells (MSCs) or pluripotent stem cells (PSCs) to mimic different phases of endochondral ossification (ECO), as one of the ma…
View article: Occurrence of cellular senescence in chronic human shoulder tendinopathies and its attenuation ex vivo by inhibition of Enhancer of Zeste 2
Occurrence of cellular senescence in chronic human shoulder tendinopathies and its attenuation ex vivo by inhibition of Enhancer of Zeste 2 Open
Aims Our aim was to investigate occurrence of senescent cells directly in tendon tissue biopsies from patients with chronic shoulder tendinopathies, and to correlate senescence with Enhancer of zeste 2 (EZH2) expression, the functional sub…
View article: Modeling Human Bone Marrow Endosteal Niches Using Induced Pluripotent Stem Cells in Xeno-Free Conditions
Modeling Human Bone Marrow Endosteal Niches Using Induced Pluripotent Stem Cells in Xeno-Free Conditions Open
View article: Tonsil explants as a human in vitro model to study vaccine responses
Tonsil explants as a human in vitro model to study vaccine responses Open
Introduction Vaccination is one of the most effective infection prevention strategies. Viruses with high mutation rates -such as influenza- escape vaccine-induced immunity and represent significant challenges to vaccine design. Influenza v…
View article: Engineered autologous nasal cartilage for repair of nasal septal perforations: a case series
Engineered autologous nasal cartilage for repair of nasal septal perforations: a case series Open
Objective: This phase I clinical trial assessed the use of autologous nasal chondrocyte tissue-engineered cartilage (N-TEC) for functional repair of nasal septal perforations (NSP). Background: The most widely used technique to treat NSP, …
View article: Engineered human osteoarthritic cartilage organoids
Engineered human osteoarthritic cartilage organoids Open
The availability of human cell-based models capturing molecular processes of cartilage degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1], a currently unmet clinical need. Here, by imposing specif…
View article: Engineered Cartilage from Nasal Chondrocytes for Knee Repair: Clinical Relevance of Tissue Maturation in a Randomized, Multicenter Phase 2 Trial
Engineered Cartilage from Nasal Chondrocytes for Knee Repair: Clinical Relevance of Tissue Maturation in a Randomized, Multicenter Phase 2 Trial Open
View article: Engineered phalangeal grafts for children with symbrachydactyly: A proof of concept
Engineered phalangeal grafts for children with symbrachydactyly: A proof of concept Open
Tissue engineering approaches hold great promise in the field of regenerative medicine, especially in the context of pediatric applications, where ideal grafts need to restore the function of the targeted tissue and consider growth. In the…
View article: Harnessing human adipose-derived stromal cell chondrogenesis in vitro for enhanced endochondral ossification
Harnessing human adipose-derived stromal cell chondrogenesis in vitro for enhanced endochondral ossification Open
Endochondral ossification (ECO), the major ossification process during embryogenesis and bone repair, involves the formation of a cartilaginous template remodelled into a functional bone organ. Adipose-derived stromal cells (ASC), non-skel…
View article: Tonsil explants as a human in vitro model to study immune responses to vaccines
Tonsil explants as a human in vitro model to study immune responses to vaccines Open
Vaccination is one of the most effective infection prevention strategies. Viruses with high mutation rates -such as influenza- escape vaccine-induced immunity and represent significant challenges to vaccine design. Influenza vaccine strain…
View article: Failure to launch commercially-approved mesenchymal stromal cell therapies: what's the path forward? Proceedings of the International Society for Cell & Gene Therapy (ISCT) Annual Meeting Roundtable held in May 2023, Palais des Congrès de Paris, Organized by the ISCT MSC Scientific Committee
Failure to launch commercially-approved mesenchymal stromal cell therapies: what's the path forward? Proceedings of the International Society for Cell & Gene Therapy (ISCT) Annual Meeting Roundtable held in May 2023, Palais des Congrès de Paris, Organized by the ISCT MSC Scientific Committee Open
Mesenchymal stromal cells (MSCs) are promising cell therapy candidates, but their debated efficacy in clinical trials still limits successful adoption. Here, we discuss proceedings from a roundtable session titled "Failure to Launch Mesenc…
View article: Bone metastatic niche: Advancing prospective models for investigating prostate cancer and bone microenvironment interactions
Bone metastatic niche: Advancing prospective models for investigating prostate cancer and bone microenvironment interactions Open
View article: Patient-derived tissue empowers rapid and personalized drug testing: Harnessing the potential of perfusion bioreactors in prostate cancer
Patient-derived tissue empowers rapid and personalized drug testing: Harnessing the potential of perfusion bioreactors in prostate cancer Open
View article: Modelling Osteoarthritis pathogenesis through Mechanical Loading in an Osteochondral Unit-on-Chip
Modelling Osteoarthritis pathogenesis through Mechanical Loading in an Osteochondral Unit-on-Chip Open
A cure for osteoarthritis (OA), the most prevalent musculoskeletal disease, remains an unmet need. Investigating the molecular and cellular processes leading to OA is challenged by the absence of human models that capture the complex inter…
View article: Editorial Board
Editorial Board Open
View article: Editorial Board
Editorial Board Open
View article: A perfusion-based three-dimensional cell culture system to model alveolar rhabdomyosarcoma pathological features
A perfusion-based three-dimensional cell culture system to model alveolar rhabdomyosarcoma pathological features Open
Although a rare disease, rhabdomyosarcoma (RMS) is one of the most common cancers in children the more aggressive and metastatic subtype is the alveolar RMS (ARMS). Survival outcomes with metastatic disease remain dismal and the need for n…
View article: Editorial Board
Editorial Board Open
View article: Patient-Derived 3D Models for Preclinical Drug Response Evaluation in Neuroblastoma
Patient-Derived 3D Models for Preclinical Drug Response Evaluation in Neuroblastoma Open
Background Neuroblastoma is the most common solid childhood tumor outside the central nervous system. Metastatic and relapsed disease in neuroblastoma patients still has a poor prognosis. New treatment methods to improve therapy and outcom…
View article: An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue–derived MSCs for research purposes
An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue–derived MSCs for research purposes Open
The rapidly growing field of mesenchymal stromal cell (MSC) basic and translational research requires standardization of terminology and functional characterization. The International Standards Organization's (ISO) Technical Committee (TC)…