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View article: SUN-451 Adrenalectomy improves cardiovascular risk factors in patients with mild autonomous cortisol secretion: results of a RCT
SUN-451 Adrenalectomy improves cardiovascular risk factors in patients with mild autonomous cortisol secretion: results of a RCT Open
Disclosure: V. Morelli: None. M. Strata: None. S. Palmieri: None. C. Aresta: None. V. Favero: None. S. Frigerio: None. F. Pugliese: None. A. Musolino: None. A. Dall'Antonia: None. S. Corbetta: None. M. Arosio: None. A. Scillitani: None. I.…
View article: Macro-FSH is a rare cause of inappropriately high FSH concentrations
Macro-FSH is a rare cause of inappropriately high FSH concentrations Open
Summary Assessment of hormone concentrations can be subjected to laboratory pitfalls. Macro-hormones are hormone–autoantibody complexes which are cleared slowly from circulation and cause a false elevation in hormones’ concentrations. Macr…
View article: Response to: Letter to the Editor From Fitzpatrick et al: “Zoledronate After Denosumab Discontinuation: Is Repeated Administrations More Effective Than Single Infusion?”
Response to: Letter to the Editor From Fitzpatrick et al: “Zoledronate After Denosumab Discontinuation: Is Repeated Administrations More Effective Than Single Infusion?” Open
Journal Article Corrected proof Response to: Letter to the Editor From Fitzpatrick et al: "Zoledronate After Denosumab Discontinuation: Is Repeated Administrations More Effective Than Single Infusion?" Get access Giorgia Grassi, Giorgia Gr…
View article: High Prevalence of Hypercalcitoninemia in a Large Cohort of Adult and Pediatric Patients With PTH Resistance Syndromes
High Prevalence of Hypercalcitoninemia in a Large Cohort of Adult and Pediatric Patients With PTH Resistance Syndromes Open
Context Pseudohypoparathyroidism (PHP) refers to a group of rare hereditary disorders associated with resistance to parathyroid hormone (PTH) and other hormones now termed inactivating PTH/PTHrP disorders (iPPSD). Hypercalcitoninemia has b…
View article: Targeted silencing of GNAS in a human model of osteoprogenitor cells results in the deregulation of the osteogenic differentiation program
Targeted silencing of GNAS in a human model of osteoprogenitor cells results in the deregulation of the osteogenic differentiation program Open
Introduction The dysregulation of cell fate toward osteoprecursor cells associated with most GNAS -based disorders may lead to episodic de novo extraskeletal or ectopic bone formation in subcutaneous tissues. The bony lesion distribution s…
View article: Testosterone Therapy Does Not Affect Coagulation in Male Hypogonadism: A Longitudinal Study Based on Thrombin Generation
Testosterone Therapy Does Not Affect Coagulation in Male Hypogonadism: A Longitudinal Study Based on Thrombin Generation Open
Context Testosterone therapy has been variably associated with increased thrombotic risk but investigations of global coagulation in this setting are lacking. Objective This work aimed to compare global coagulation of hypogonadal men befor…
View article: Zoledronate After Denosumab Discontinuation: Is Repeated Administrations More Effective Than Single Infusion?
Zoledronate After Denosumab Discontinuation: Is Repeated Administrations More Effective Than Single Infusion? Open
Background After denosumab (Dmab) discontinuation C-terminal telopeptide (CTX) levels increase, bone mineral density (BMD) decreases and multiple vertebral fractures (FX) may occur with relevant impacts on women's health. A sequential ther…
View article: Recurrence in acromegaly: two tertiary centers experience and review of the literature
Recurrence in acromegaly: two tertiary centers experience and review of the literature Open
Background Recurrence of acromegaly after successful surgery is a rare event, but no clear data are reported in the literature about its recurrence rates. This study aimed to evaluate the recurrence rate in a series of acromegalic patients…
View article: Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy
Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy Open
View article: Targeted silencing of <i>GNAS </i>in a human model of osteoprogenitor cells results in the deregulation of the osteogenic differentiation program
Targeted silencing of <i>GNAS </i>in a human model of osteoprogenitor cells results in the deregulation of the osteogenic differentiation program Open
These datasets contain the ordinal data in the article "Targeted silencing of GNAS in a human model of osteoprogenitor cells results in the deregulation of the osteogenic differentiation program."
View article: High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery Open
Objective The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not dev…
View article: High Filamin a Expression in Adrenocortical Carcinomas Is Associated with a Favourable Tumour Behaviour: A European Multicentric Study
High Filamin a Expression in Adrenocortical Carcinomas Is Associated with a Favourable Tumour Behaviour: A European Multicentric Study Open
The insulin-like growth factor 2 (IGF2) promotes cell growth by overactivating the IGF system in an autocrine loop in adrenocortical carcinomas (ACCs). The cytoskeleton protein filamin A (FLNA) acts as a repressor of IGF2 mitogenic signall…
View article: The adult growth hormone multicentric retrospective observational study: a 24-month Italian experience of adherence monitoring via Easypod™ of recombinant growth hormone treatment in adult GH deficiency
The adult growth hormone multicentric retrospective observational study: a 24-month Italian experience of adherence monitoring via Easypod™ of recombinant growth hormone treatment in adult GH deficiency Open
Introduction Non-compliance to recombinant human growth hormone (rhGH) treatment is universally recognized as a key detrimental factor to achieve the expected clinical outcomes in adult GH deficiency (aGHD). The Easypod™ electronic device …
View article: THU617 Prolonged Exposure To Target Mitotane Concentrations Is Associated With Better Recurrence-free Survival In Patients With Adrenocortical Carcinoma On Adjuvant Treatment
THU617 Prolonged Exposure To Target Mitotane Concentrations Is Associated With Better Recurrence-free Survival In Patients With Adrenocortical Carcinoma On Adjuvant Treatment Open
Disclosure: S. Puglisi: None. A. Calabrese: None. V. Basile: None. O. Kimpel: Speaker; Self; HRA Pharmaceuticals. B. Altieri: None. A. Angelousi: None. G. Kaltsas: None. U. Ambroziak: None. M.L. Appetecchia: None. M. Arosio: None. A. Berru…
View article: The association of hypogonadism with depression and its treatments
The association of hypogonadism with depression and its treatments Open
According to World Health Organization estimates, 5% of the adult population worldwide suffers from depression. In addition to the affective, psychomotor and cognitive symptoms which characterize this mood disorder, sexual dysfunction has …
View article: Prevalence and clinical features of armadillo repeat-containing 5 mutations carriers in a single center cohort of patients with bilateral adrenal incidentalomas
Prevalence and clinical features of armadillo repeat-containing 5 mutations carriers in a single center cohort of patients with bilateral adrenal incidentalomas Open
Objective We aimed to evaluate the prevalence of armadillo repeat-containing 5 (ARMC5) genetic defects in our cohort of bilateral adrenal incidentaloma (BAI) patients and to evaluate the possible existence of genotype–phenotype correlation…
View article: A β-Arrestin 2-Biased Dopamine Receptor Type 2 (DRD2) Agonist Is More Efficacious Than Cabergoline in Reducing Cell Proliferation in PRL-Secreting but Not in Non-Functioning Pituitary Tumor Cells
A β-Arrestin 2-Biased Dopamine Receptor Type 2 (DRD2) Agonist Is More Efficacious Than Cabergoline in Reducing Cell Proliferation in PRL-Secreting but Not in Non-Functioning Pituitary Tumor Cells Open
The molecular events underlying the variable effectiveness of dopamine receptor type 2 (DRD2) agonists in pituitary neuroendocrine tumors (PitNETs) are not known. Besides the canonical pathway induced by DRD2 coupling with Gi proteins, the…
View article: Correction: The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors
Correction: The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors Open
View article: Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry
Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry Open
Original dataset of the study
View article: Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry
Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry Open
Objective An evidence-based pubertal induction scheme in hypogonadal girls is still to be established. Interestingly, literature data report a suboptimal uterine longitudinal diameter (ULD) in >50% of treated hypogonadal women, negative…
View article: IGF2R: a new player in the insulin-like growth factor 2 (IGF2) pathway sustaining adrenocortical carcinoma cells growth
IGF2R: a new player in the insulin-like growth factor 2 (IGF2) pathway sustaining adrenocortical carcinoma cells growth Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors
The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors Open
Background Similarly to cortisol-secreting adrenal tumors, also non-functioning adrenal tumors (NFAT) may be associated with an increased cardiovascular risk. We assessed in NFAT patients: (i) the association between hypertension (HT), dia…
View article: Neonatal and Early Infancy Features of Patients With Inactivating PTH/PTHrP Signaling Disorders/Pseudohypoparathyroidism
Neonatal and Early Infancy Features of Patients With Inactivating PTH/PTHrP Signaling Disorders/Pseudohypoparathyroidism Open
Background Pseudohypoparathyroidism (PHP) and related disorders newly referred to as inactivating PTH/PTHrP signaling disorders (iPPSD) are rare endocrine diseases. Many clinical features including obesity, neurocognitive impairment, brach…
View article: Bone Disease in Long-Term Lung Transplant Survivors
Bone Disease in Long-Term Lung Transplant Survivors Open
Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15–50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseas…
View article: Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome Open
Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUS…
View article: The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors
The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors Open
This is a database used for a retrospective observational study, about patients with nonfuncioning adrenal tumors. We recorded the available clinical and biochemical data of all patients with adrenal incidentalomas and without mild autonom…
View article: The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors
The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors Open
This is a database used for a retrospective observational study, about patients with nonfuncioning adrenal tumors. We recorded the available clinical and biochemical data of all patients with adrenal incidentalomas and without mild autonom…
View article: Effects of the therapy shift from cortisone acetate to modified-release hydrocortisone in a group of patients with adrenal insufficiency
Effects of the therapy shift from cortisone acetate to modified-release hydrocortisone in a group of patients with adrenal insufficiency Open
Objective Patients with adrenal insufficiency (AI) may be exposed to supraphysiological glucocorticoids levels during standard treatment with cortisone acetate (CA) or immediate-release hydrocortisone (IR-HC). Recent studies, predominantly…
View article: Body mass index versus surrogate measures of central adiposity as independent predictors of mortality in type 2 diabetes
Body mass index versus surrogate measures of central adiposity as independent predictors of mortality in type 2 diabetes Open
Background An “obesity paradox” for mortality has been shown in chronic disorders such as diabetes, and attributed to methodological bias, including the use of body mass index (BMI) for obesity definition. This analysis investigated the in…
View article: Short stature in PRMT7 Mutations: first evidence of response to growth hormone treatment
Short stature in PRMT7 Mutations: first evidence of response to growth hormone treatment Open