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View article: Clinical Characteristics and Outcomes of Rome <scp>IV</scp> Diarrhea‐Predominant Irritable Bowel Syndrome and Functional Diarrhea Prescribed With Ondansetron: A Real‐World Study
Clinical Characteristics and Outcomes of Rome <span>IV</span> Diarrhea‐Predominant Irritable Bowel Syndrome and Functional Diarrhea Prescribed With Ondansetron: A Real‐World Study Open
Background 5‐HT3 receptor antagonists, such as ondansetron, are effective in the management of irritable bowel syndrome‐diarrhea predominant (IBS‐D). However, real‐world data and evidence exploring the response to ondansetron in patients w…
View article: Prevalence of Opioid Use and Associated Healthcare Outcomes in Rome <scp>IV</scp> Irritable Bowel Syndrome in the United Kingdom
Prevalence of Opioid Use and Associated Healthcare Outcomes in Rome <span>IV</span> Irritable Bowel Syndrome in the United Kingdom Open
Background The United Kingdom (UK) has one of the highest worldwide opioid prescription rates per capita. International guidelines caution against the use of opioids for chronic non‐malignant pain, including irritable bowel syndrome (IBS).…
View article: New Basic Science Editor and New Journal Management Committee Chair of Neurogastroenterology and Motility!
New Basic Science Editor and New Journal Management Committee Chair of Neurogastroenterology and Motility! Open
View article: Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide
Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide Open
Background Antispasmodic agents are used to treat abdominal pain. The mode of action of pinaverium bromide and propinox in the colonic tissue has never been characterized. This study aimed to explore whether HBB can complement the antispas…
View article: Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review
Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review Open
Background Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal (GI) disorders worldwide. Defined as a disorder of gut‐brain interaction, its pathophysiology is still not completely clear. Consequently, current trea…
View article: Clinical Characteristics and Outcomes of Patients With Rome <scp>IV</scp> Functional Dyspepsia Who Consume Opioids: A Real‐World Study
Clinical Characteristics and Outcomes of Patients With Rome <span>IV</span> Functional Dyspepsia Who Consume Opioids: A Real‐World Study Open
Introduction The prevalence of opioid use and its impact on healthcare outcomes among patients with Rome IV functional dyspepsia (FD) has not been reported in real‐world clinical practice in the United Kingdom (UK). The primary aim of this…
View article: Impact of Opioid and Cannabis Use on Low‐Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real‐World Study in the United Kingdom
Impact of Opioid and Cannabis Use on Low‐Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real‐World Study in the United Kingdom Open
Background Central neuromodulators, specifically tricyclic antidepressants (TCAs), are prescribed as prophylactic treatment for cyclical vomiting syndrome (CVS). It is unclear whether opioids and/or cannabis affect the treatment response t…
View article: Gastroenterology Training and Career in Women: Challenges and Opportunities
Gastroenterology Training and Career in Women: Challenges and Opportunities Open
This review highlights gender gaps in training, career, and work‐life balance in gastroenterology. Stereotypes and biases toward women’s abilities and commitment to their careers can influence evaluations, advancement in gastroenterology t…
View article: Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats
Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats Open
Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the…
View article: European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management
European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management Open
Introduction Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non‐gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well‐structured approach. If the initial investigatio…
View article: A Medical Student Curriculum on Functional Medical Disorders
A Medical Student Curriculum on Functional Medical Disorders Open
Background Functional medical disorders (FMDs) refer to persistent physical symptoms that cause impairment or disability, but which cannot be explained by routine medical testing. Negative perceptions towards FMDs exist amongst a variety o…
View article: Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers
Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers Open
View article: Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo‐controlled Trial in Constipation
Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo‐controlled Trial in Constipation Open
Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo‐controlled cross‐over trials were performed, one using…
View article: Editorial: Rebuilding Rome—Revising Diagnostic Criteria for Irritable Bowel Syndrome
Editorial: Rebuilding Rome—Revising Diagnostic Criteria for Irritable Bowel Syndrome Open
View article: Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study
Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study Open
Background Colonic motility in constipation can be assessed non-invasively using MRI. Objective To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response. Design Part 1: 44 healthy volunteers (HVs), 43 …
View article: And also, the basic science team of <i>Neurogastroenterology and Motility</i> gets younger!
And also, the basic science team of <i>Neurogastroenterology and Motility</i> gets younger! Open
View article: Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility
Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility Open
Transition services—programs that support adolescents and young adults (AYAs) as they move from a child‐centered to a more autonomous, adult‐orientated healthcare system—have been associated with improved short‐ and long‐term healthcare ou…
View article: Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: human ex-vivo study
Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: human ex-vivo study Open
Introduction Drotaverine, paracetamol, and peppermint oil are often prescribed for the treatment of gastrointestinal spasm and pain. This study aimed to evaluate the effect of these drugs alone and combined with the well-known antispasmodi…
View article: Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms
Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms Open
View article: New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo
New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo Open
View article: Functional variation in human Carbohydrate-Active enZYmes (hCAZymes) in relation to the efficacy of a FODMAP-reducing diet in IBS patients
Functional variation in human Carbohydrate-Active enZYmes (hCAZymes) in relation to the efficacy of a FODMAP-reducing diet in IBS patients Open
Objective Limiting the dietary intake of carbohydrates poorly absorbed in the small intestine (FODMAPs) has therapeutic effects in some but not all irritable bowel syndrome (IBS) patients. We investigated genetic variation in human Carbohy…
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View article: Perceptions, Definitions, and Therapeutic Interventions for Occasional Constipation: A Rome Working Group Consensus Document
Perceptions, Definitions, and Therapeutic Interventions for Occasional Constipation: A Rome Working Group Consensus Document Open
View article: Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial
Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial Open
Background Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, ha…
View article: Neurogastroenterology and Motility gets younger!
Neurogastroenterology and Motility gets younger! Open
The Editors are pleased to introduce all of you to our new Trainee Editors and to invite you to read their interesting minireview on the important issue of the Lack of awareness of Neurogastroenterology and Motility within medical educatio…
View article: Appropriate use of <i>p</i>‐values
Appropriate use of <i>p</i>‐values Open
The use of statistics, particularly inferential statistics, is ubiquitous in most areas of medical research. Because we usually only have data from samples, and sometimes quite small samples, the ability to differentiate treatment benefits…
View article: Symptom Subgroups Taking Into Account Psychological Burden Predicts Irritable Bowel Syndrome Disease Impact and Burden: A Step Forward?
Symptom Subgroups Taking Into Account Psychological Burden Predicts Irritable Bowel Syndrome Disease Impact and Burden: A Step Forward? Open
View article: The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study
The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study Open
Background There are minimal epidemiological data comparing the burden of disorders of gut brain interaction (DGBI) in the UK with other countries. We compared the prevalence of DGBI in the UK with other countries that participated in the …
View article: News from the Editors
News from the Editors Open
View article: Randomised, placebo‐controlled trial and meta‐analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The <scp>TRITON</scp> trial
Randomised, placebo‐controlled trial and meta‐analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The <span>TRITON</span> trial Open
Summary Background Ondansetron may be beneficial in irritable bowel syndrome with diarrhoea (IBS‐D). Aim To conduct a 12‐week parallel group, randomised, double‐blind, placebo‐controlled trial of ondansetron 4 mg o.d. (titrated up to 8 mg …