Maura Manion
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View article: Taurine and a-ketoglutarate induce innate immune memory in macrophages and facilitate the reactivation of latently infected HIV by β-glucan and MDP 9276
Taurine and a-ketoglutarate induce innate immune memory in macrophages and facilitate the reactivation of latently infected HIV by β-glucan and MDP 9276 Open
Description The induction of innate immune memory and consequent trained immunity has several potential applications within the biomedical field. For instance, training with established stimuli such as BCG vaccination and β-glucan has prev…
View article: Infection‐Associated Immune Reconstitution Inflammatory Syndrome in Hematopoietic Cell Transplantation
Infection‐Associated Immune Reconstitution Inflammatory Syndrome in Hematopoietic Cell Transplantation Open
Immune reconstitution inflammatory syndrome (IRIS) is a well‐recognized complication in people with HIV (PWH) starting antiretroviral therapy (ART), but data on IRIS in hematopoietic cell transplantation (HCT) recipients are limited. To ad…
View article: Impact of Anti-CD4 Autoantibodies on Immune Reconstitution in People With Advanced HIV
Impact of Anti-CD4 Autoantibodies on Immune Reconstitution in People With Advanced HIV Open
Background Despite suppressive antiretroviral therapy (ART), 15%–30% of people with human immunodeficiency virus (HIV) experience a limited recovery of CD4 T cells. Although autoantibodies against the CD4 receptor have previously been iden…
View article: Proliferation of a Novel CD3neg Hyperactivated T-Cell Population Characterizes Adult Hemophagocytic Lymphohistiocytosis and Associates with Disease Activity
Proliferation of a Novel CD3neg Hyperactivated T-Cell Population Characterizes Adult Hemophagocytic Lymphohistiocytosis and Associates with Disease Activity Open
Introduction: Pathologic T-cell activation occurs in children with hemophagocytic lymphohistiocytosis (HLH) leading to increased IFNγ production which drives its pathogenesis. However, HLH in adults can occur due to diverse etiologies with…
View article: Perplexing paradoxical reactions: navigating the complexity of protracted tuberculosis meningitis—a case report
Perplexing paradoxical reactions: navigating the complexity of protracted tuberculosis meningitis—a case report Open
Tuberculous meningitis (TBM) has considerable mortality and morbidity, and it often presents therapeutic challenges when complicated by paradoxical reactions (PRs). Here, the clinical course of four cases of TBM patients complicated by PRs…
View article: A multidisciplinary approach to mucormycosis
A multidisciplinary approach to mucormycosis Open
Mucormycosis is a life-threatening fungal infection that typically affects highly immunocompromised hosts. In contrast to invasive candidiasis and aspergillosis, the therapeutic arsenal available to treat mucormycosis is limited. In the ab…
View article: Inflammasome activation in patients with Kaposi sarcoma herpesvirus–associated diseases
Inflammasome activation in patients with Kaposi sarcoma herpesvirus–associated diseases Open
Kaposi sarcoma herpesvirus (KSHV)–associated diseases include Kaposi sarcoma (KS), primary effusion lymphoma (PEL), KSHV-associated multicentric Castleman disease (MCD), and KS inflammatory cytokine syndrome (KICS). PEL, MCD, and KICS are …
View article: Neurological manifestations of nontuberculous mycobacteria in adults: case series and review of the literature
Neurological manifestations of nontuberculous mycobacteria in adults: case series and review of the literature Open
Introduction Nontuberculous mycobacteria (NTM) mediated infections are important to consider in cases with neuroinflammatory presentations. We aimed to characterize cases of NTM with neurological manifestations at the National Institutes o…
View article: Prevalence of anti-lymphocyte IgM autoantibodies driving complement activation in COVID-19 patients
Prevalence of anti-lymphocyte IgM autoantibodies driving complement activation in COVID-19 patients Open
Introduction COVID-19 patients can develop autoantibodies against a variety of secreted and membrane proteins, including some expressed on lymphocytes. However, it is unclear what proportion of patients might develop anti-lymphocyte antibo…
View article: Clonal hematopoiesis in people with advanced HIV and associated inflammatory syndromes
Clonal hematopoiesis in people with advanced HIV and associated inflammatory syndromes Open
People with HIV (PWH) have a higher age-adjusted mortality due to chronic immune activation and age-related comorbidities. PWH also have higher rates of clonal hematopoiesis (CH) than age-matched non-HIV cohorts; however, risk factors infl…
View article: 2701. Mycobacterial Immune Reconstitution Inflammatory Syndrome Following Hematopoietic Cell Transplantation for GATA2 Deficiency
2701. Mycobacterial Immune Reconstitution Inflammatory Syndrome Following Hematopoietic Cell Transplantation for GATA2 Deficiency Open
Background Immune reconstitution inflammatory syndrome (IRIS) was first described in patients with HIV and opportunistic infections starting antiretroviral therapy, but may be seen following hematopoietic cell transplantation (HCT) in pati…
View article: Long-term Outcomes of Patients With HIV and <i>Pneumocystis jirovecii</i> Pneumonia in the Antiretroviral Therapy Era
Long-term Outcomes of Patients With HIV and <i>Pneumocystis jirovecii</i> Pneumonia in the Antiretroviral Therapy Era Open
Background Pneumocystis jirovecii pneumonia (PCP) is one of the most frequent opportunistic infections in people with HIV (PWH). However, there are limited data on long-term outcomes of PCP in the antiretroviral therapy (ART) era. Methods …
View article: An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV
An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV Open
Background: Residual inflammation in people with HIV (PWH) despite suppression of HIV replication is associated with many comorbidities including cardiovascular disease. Targeting inflammation may decrease the risk of cardiovascular diseas…
View article: Reappraisal of Idiopathic CD4 Lymphocytopenia at 30 Years
Reappraisal of Idiopathic CD4 Lymphocytopenia at 30 Years Open
Among the study patients, ICL continued to be associated with increased susceptibility to viral, encapsulated fungal, and mycobacterial diseases, as well as with a reduced response to novel antigens and an increased risk of cancer. (Funded…
View article: New Complement Dependent Cytotoxicity Assay and its application to COVID-19 patient sera harboring anti-lymphocyte antibodies
New Complement Dependent Cytotoxicity Assay and its application to COVID-19 patient sera harboring anti-lymphocyte antibodies Open
Complement dependent cytotoxicity (CDC) is one of the ways IgM and IgG antibodies can mediate the lysis of target cells, being IgM the antibody (Ab) isotype with the highest CDC activity. In a cohort of hospitalized COVID-19 patients we id…
View article: Prevalence and complement activation of anti-lymphocyte IgM antibodies in hospitalized COVID-19 patients
Prevalence and complement activation of anti-lymphocyte IgM antibodies in hospitalized COVID-19 patients Open
Recent studies have shown that a proportion of COVID-19 patients develop auto-antibodies against a wide range of secreted and membrane proteins, some of which are expressed by lymphocytes. It is unclear, however, if and what proportion of …
View article: Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related Genes
Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related Genes Open
People with HIV (PWH) and mycobacterial infections can develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy. The pathophysiology of mycobacterial-IRIS overlaps with primary hemophagocytic lymphoh…
View article: Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression
Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression Open
Background People with HIV and mycobacterial infections can develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy (ART). Severe mycobacterial IRIS has an overlapping clinical phenotype with hemoph…
View article: Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment
Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment Open
Background Nirmatrelvir/ritonavir, the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease inhibitor, reduces the risk of hospitalization and death by coronavirus disease 2019 (COVID-19) but has been associated with…
View article: Characteristics of patients admitted to the ICU with Kaposi sarcoma herpesvirus-associated diseases
Characteristics of patients admitted to the ICU with Kaposi sarcoma herpesvirus-associated diseases Open
Objective: There are four conditions caused by Kaposi sarcoma herpesvirus (KSHV): Kaposi sarcoma, KSHV-associated multicentric Castleman disease (MCD), primary effusion lymphoma (PEL), and KSHV inflammatory cytokine syndrome (KICS). These …
View article: Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome
Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome Open
In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characteriz…
View article: Improvement of liver metabolic activity in people with advanced HIV after antiretroviral therapy initiation
Improvement of liver metabolic activity in people with advanced HIV after antiretroviral therapy initiation Open
Objective: Evaluating hepatic metabolic changes in people with HIV (PWH) with advanced disease, before and after antiretroviral therapy (ART) initiation, using [ 18 F]-fluorodeoxyglucose (FDG) PET-computed tomography (PET/CT). FDG PET/CT n…
View article: COVID-19 redux: clinical, virologic, and immunologic evaluation of clinical rebound after nirmatrelvir/ritonavir
COVID-19 redux: clinical, virologic, and immunologic evaluation of clinical rebound after nirmatrelvir/ritonavir Open
Clinical rebound of COVID-19 after nirmatrelvir/ritonavir treatment has been reported. We performed clinical, virologic, and immune measurements in seven patients with symptomatic rebound, six after nirmatrelvir/ritonavir treatment and one…
View article: Activation of Complement Components on Circulating Blood Monocytes From COVID-19 Patients
Activation of Complement Components on Circulating Blood Monocytes From COVID-19 Patients Open
The coronavirus disease-2019 (COVID-19) caused by the SARS-CoV-2 virus may vary from asymptomatic to severe infection with multi-organ failure and death. Increased levels of circulating complement biomarkers have been implicated in COVID-1…
View article: Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16− Monocytes From COVID-19 Patients
Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16− Monocytes From COVID-19 Patients Open
The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is associated with systemic hyperinflammatory response and immunopathology. Although inflammasome and oxidative stress have independently been implicated in…
View article: Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease
Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease Open
Low nadir CD4 T-cell counts in HIV + patients are associated with high morbidity and mortality and lasting immune dysfunction, even after antiretroviral therapy (ART). The early events of immune recovery of T cells and B cells in severely …
View article: Persistent oxidative stress and inflammasome activation in CD14<sup>high</sup>CD16<sup>-</sup>monocytes from COVID-19 patients
Persistent oxidative stress and inflammasome activation in CD14<sup>high</sup>CD16<sup>-</sup>monocytes from COVID-19 patients Open
The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is associated with systemic hyperinflammatory response and immunopathology. Although inflammasome and oxidative stress have independently been implicated in…