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View article: Pulmonary adaptation to repeated poly(I:C) exposure is impaired in asthmatic mice: an observational study
Pulmonary adaptation to repeated poly(I:C) exposure is impaired in asthmatic mice: an observational study Open
View article: Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers
Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers Open
Recurrent preschool wheezers represent approximately 10% of children under 5 years of age. Among them, those who report frequent exacerbations (ie, or more per year), mainly due to viral and/or bacterial infections, have an increased risk …
View article: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Open
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contact between resident cells and immune cells. Tissue fibrocytes interaction with CD8 + T cells and its consequences…
View article: Author Response: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Author Response: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Peer review Author response Article and author information Metrics Abstract Bro…
View article: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Open
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T cells and its consequences…
View article: Author Response: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Author Response: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Open
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T cells and its consequences…
View article: Bronchial smooth muscle remodelling impacts the exacerbation frequency of severe preschool wheezers
Bronchial smooth muscle remodelling impacts the exacerbation frequency of severe preschool wheezers Open
INTRODUCTION: Exacerbations in preschool wheezers increase the risk of impaired lung function and asthma persistence at school age. Bronchial remodelling-based latent classes identify severe preschool wheezers at increased risk of frequent…
View article: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Open
The peri-bronchial zone of chronic obstructive pulmonary disease (COPD) is the site of extensive infiltration of immune cell, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T c…
View article: Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Open
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contact between resident cells and immune cells. Tissue fibrocytes interaction with CD8 + T cells and its consequences…
View article: Reviewer #2 (Public Review): Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Reviewer #2 (Public Review): Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Open
The peri-bronchial zone of chronic obstructive pulmonary disease (COPD) is the site of extensive infiltration of immune cell, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T c…
View article: CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD
CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD Open
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease lacking effective treatment. Focusing on early COPD should help to discover disease modifying therapies. We aimed to examine the role of the CXCL12/CXCR4 axis …
View article: Probabilistic cellular automata modelling of intercellular interactions in airways: complex pattern formation in patients with chronic obstructive pulmonary disease
Probabilistic cellular automata modelling of intercellular interactions in airways: complex pattern formation in patients with chronic obstructive pulmonary disease Open
View article: Short-range interactions between fibrocytes and CD8 <sup>+</sup> T cells in COPD bronchial inflammatory response
Short-range interactions between fibrocytes and CD8 <sup>+</sup> T cells in COPD bronchial inflammatory response Open
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8 + T cells and its consequence…
View article: Muscarinic receptor M3 activation promotes fibrocytes contraction
Muscarinic receptor M3 activation promotes fibrocytes contraction Open
Fibrocytes are monocyte-derived cells able to differentiate into myofibroblasts-like cells. We have previously shown that they are increased in the bronchi of Chronic Obstructive Pulmonary Disease (COPD) patients and associated to worse lu…
View article: Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium
Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium Open
Rhinovirus (RV) infection of the bronchial epithelium is implicated in the vast majority of severe asthma exacerbations. Interestingly, the susceptibility of bronchial epithelium to RV infection is increased in persons with asthma. Bronchi…
View article: Probabilistic Cellular Automata modeling of intercellular interactions in airways:complex pattern formation in patients with Chronic Obstructive Pulmonary Disease
Probabilistic Cellular Automata modeling of intercellular interactions in airways:complex pattern formation in patients with Chronic Obstructive Pulmonary Disease Open
View article: Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling
Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling Open
Background Bronchial smooth muscle (BSM) remodelling in asthma is related to an increased mitochondrial biogenesis and enhanced BSM cell proliferation in asthma. Since mitochondria produce the highest levels of cellular energy and fatty ac…
View article: Implication of Mitochondrial Metabolism in Bronchial Smooth Muscle Remodeling in Asthma
Implication of Mitochondrial Metabolism in Bronchial Smooth Muscle Remodeling in Asthma Open
View article: Asthmatic Bronchial Smooth Muscle Increases CCL5-Dependent Monocyte Migration in Response to Rhinovirus-Infected Epithelium
Asthmatic Bronchial Smooth Muscle Increases CCL5-Dependent Monocyte Migration in Response to Rhinovirus-Infected Epithelium Open
Asthma exacerbations, a major concern in therapeutic strategies, are most commonly triggered by viral respiratory infections, particularly with human rhinovirus (HRV). Infection of bronchial epithelial (BE) cells by HRV triggers inflammati…
View article: Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease
Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease Open
The mechanisms underlying pulmonary hypertension (PH) are complex and multifactorial, and involve different cell types that are interconnected through gap junctional channels. Although connexin (Cx)-43 is the most abundant gap junction pro…