Maureen DeMarshall
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View article: Clonal cell states link gastroesophageal junction tissues with metaplasia and cancer
Clonal cell states link gastroesophageal junction tissues with metaplasia and cancer Open
Barrett’s esophagus is a common type of metaplasia and a precursor of esophageal adenocarcinoma. However, the cell states and lineage connections underlying the origin, maintenance, and progression of Barrett’s esophagus have not been reso…
View article: Mitochondrial clone tracing within spatially intact human tissues
Mitochondrial clone tracing within spatially intact human tissues Open
Understanding tissue development and intra-tissue evolution requires the ability to trace clones in intact tissues coupled with high-plex molecular profiling preserving spatial context. However, current lineage tracing tools are incompatib…
View article: Indefinite for dysplasia in Barrett’s esophagus carries substantial risk for prevalent and incident neoplasia: updated outcomes and long-term follow-up
Indefinite for dysplasia in Barrett’s esophagus carries substantial risk for prevalent and incident neoplasia: updated outcomes and long-term follow-up Open
IND carries substantial risk for progression to neoplasia including HGD and EAC, especially in the first year after diagnosis. Incident HGD and EAC risk approximates that published for LGD.
View article: Data from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus
Data from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus Open
Background: Better methods are needed to predict risk of progression for Barrett's esophagus. We aimed to determine whether a tissue systems pathology approach could predict progression in patients with nondysplastic Barrett's esophagus, i…
View article: Supplementary Tables S1-S5, Figures S1-S2, Methods from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus
Supplementary Tables S1-S5, Figures S1-S2, Methods from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus Open
Table S1. Summary of Progression Endpoints in Incident Progressor Patients. Table S2. Correlation Among Quantitative Image Analysis Features Derived from the Same Candidate Biomarkers. Table S3. Comparison of Predictive Performance of Risk…
View article: Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus
Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus Open
Background: There is a need for improved tools to detect high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. In previous work, we demonstrated that a 3-tier classifier predicted risk of inci…
View article: Supplementary Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus
Supplementary Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus Open
Table S1. 15 Image Analysis Features Utilized by the Risk Classifier Table S2. Performance of Risk Classes Predicted by Test vs. Pathologic Diagnosis in Stratifying BE Patients with Prevalent HGD/EAC from Non-Progressor BE Patients. Figure…
View article: Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus
Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus Open
Background: There is a need for improved tools to detect high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. In previous work, we demonstrated that a 3-tier classifier predicted risk of inci…
View article: Data from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus
Data from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus Open
Background: Better methods are needed to predict risk of progression for Barrett's esophagus. We aimed to determine whether a tissue systems pathology approach could predict progression in patients with nondysplastic Barrett's esophagus, i…
View article: Supplementary Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus
Supplementary Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus Open
Table S1. 15 Image Analysis Features Utilized by the Risk Classifier Table S2. Performance of Risk Classes Predicted by Test vs. Pathologic Diagnosis in Stratifying BE Patients with Prevalent HGD/EAC from Non-Progressor BE Patients. Figure…
View article: Supplementary Tables S1-S5, Figures S1-S2, Methods from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus
Supplementary Tables S1-S5, Figures S1-S2, Methods from A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus Open
Table S1. Summary of Progression Endpoints in Incident Progressor Patients. Table S2. Correlation Among Quantitative Image Analysis Features Derived from the Same Candidate Biomarkers. Table S3. Comparison of Predictive Performance of Risk…
View article: Clonal cell states link Barrett’s esophagus and esophageal adenocarcinoma
Clonal cell states link Barrett’s esophagus and esophageal adenocarcinoma Open
Barrett’s esophagus is a common type of metaplasia and a precursor of esophageal adenocarcinoma. However, the cell states and lineage connections underlying the origin, maintenance, and progression of Barrett’s esophagus have not been reso…
View article: Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer
Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer Open
3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patie…
View article: Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue
Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue Open
[This corrects the article DOI: 10.18632/oncotarget.26911.].
View article: Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue
Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue Open
Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia before developing into esophageal adenocarcinoma. The BE microenvironment is not we…
View article: Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium
Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium Open
OBJECTIVES: The literature related to eosinophilic gastritis (EG), gastroenteritis (EGE), and colitis (EC) is limited. We aimed to characterize rates of diagnosis, clinical features, and initial treatments for patients with EG, EGE, and EC…
View article: Increasing Rates of Diagnosis, Substantial Co-occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis and Colitis Based on 10 Year Data Across a Multi-Center Consortium
Increasing Rates of Diagnosis, Substantial Co-occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis and Colitis Based on 10 Year Data Across a Multi-Center Consortium Open
Financial Support and Acknowledgements Support for this project was provided through a research training grant as part of the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) (U54 AI117804). CEGIR is part of the Rare…
View article: A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus
A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus Open
Background: There is a need for improved tools to detect high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. In previous work, we demonstrated that a 3-tier classifier predicted risk of inci…
View article: A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus
A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus Open
Background: Better methods are needed to predict risk of progression for Barrett's esophagus. We aimed to determine whether a tissue systems pathology approach could predict progression in patients with nondysplastic Barrett's esophagus, i…
View article: Risk of malignant progression in Barrett's esophagus indefinite for dysplasia
Risk of malignant progression in Barrett's esophagus indefinite for dysplasia Open
Barrett's esophagus is a well-recognized risk factor for esophageal adenocarcinoma. The natural history of Barrett's esophagus classified as ‘indefinite for dysplasia’ (IND) is poorly characterized. The aim of this study is to characterize…