Explanipedia

Development of an Interactive Patient Education Tool for Genetic Testing in Autism Spectrum Disorder Open

Maurita Hung, Michael Corrin, S. D. Wall, Ny Hoang · 2019

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a prevalence of 1 in 68 children. The cause of the disorder is unknown, but research suggests that it involves a combination of genetic and environmental factors. Due to …

Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Open

Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Hong Cui , et al. · 2019

The recent cryo-electron microscopy structures of zebrafish and the human cystic fibrosis transmembrane conductance regulator (CFTR) provided unprecedented insights into putative mechanisms underlying gating of its anion channel activity. …

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Open

Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Christopher Ing , et al. · 2018

The recent cryo-electron microscopy structures of phosphorylated, ATP-bound CFTR in detergent micelles failed to reveal an open anion conduction pathway as expected on the basis of previous functional studies in biological membranes. We te…

Synthesis and characterization of a photoaffinity labelling probe based on the structure of the cystic fibrosis drug ivacaftor Open

C. Michael Hamilton, Maurita Hung, Gang Chen, Zafar Qureshi, J. R. Thompson , et al. · 2018

Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del Open

Stephanie Chin, Maurita Hung, Amy Won, Yu-Sheng Wu, Saumel Ahmadi , et al. · 2018

CCDC 1822252: Experimental Crystal Structure Determination Open

C. Michael Hamilton, Maurita Hung, Gang Chen, Zafar Qureshi, J. R. Thompson , et al. · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants Open

Stephanie Chin, Maurita Hung, Christine E. Bear · 2016

Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord Open

Wenjun Xu, Nadia Sachewsky, Ashkan Azimi, Maurita Hung, Andrew Gappasov , et al. · 2016

The adult mammalian forebrain comprises two distinct populations of neural stem cells (NSCs): rare, Oct4 positive, primitive NSCs (pNSCs) and definitive NSC (dNSC) which are more abundant and express GFAP. The pNSCs are upstream of the dNS…

The Development and Characterization of VX-770 Molecular Probes Open

Maurita Hung · 2016

Cystic fibrosis is the most common genetic disease affecting the Canadian population. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene, and there is currently no cure. In 2012, VX-770 became the fir…

Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening Open

Steven V. Molinski, Saumel Ahmadi, Maurita Hung, Christine E. Bear · 2015

Maurita Hung YOU? Author Swipe