Maurizio Martini
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View article: DUSP8 as a regulator of glioblastoma stem-like cell contribution to tumor vascularization
DUSP8 as a regulator of glioblastoma stem-like cell contribution to tumor vascularization Open
Glioblastomas (GBMs) are highly vascularized cancers. Transdifferentiation of GBM stem-like cells (GSCs) into GSC-derived endothelial cells (GdECs) contributes to GBM neovascularization. To dissect the molecular mechanisms and the signalin…
View article: Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment Strategies
Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment Strategies Open
Aseptic loosening (AL) represents the leading cause of long-term failure in total joint arthroplasty, often necessitating revision surgery. This review explores the complex mechanisms underlying AL, which involve a multifaceted interaction…
View article: Fusobacterium nucleatum and Gastric Cancer: An Emerging Connection
Fusobacterium nucleatum and Gastric Cancer: An Emerging Connection Open
Fusobacterium nucleatum (F. nucleatum), a Gram-negative anaerobe traditionally associated with periodontal disease, has recently emerged as a putative contributor to gastric carcinoma (GC) pathogenesis. Beyond its detection in gastric tiss…
View article: Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment Strategies
Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment Strategies Open
Aseptic loosening (AL) represents the leading cause of long-term failure in total joint arthroplasty, often necessitating revision surgery. This review explores the complex mechanisms underlying AL, which involve a multifaceted interaction…
View article: Morphological, immunophenotypic and neuroradiological characteristics of primitive B‑large cell diffuse lymphoma of the central nervous system: A retrospective cohort analysis
Morphological, immunophenotypic and neuroradiological characteristics of primitive B‑large cell diffuse lymphoma of the central nervous system: A retrospective cohort analysis Open
Primitive diffuse large B-cell lymphoma (PCNSL-DLBCL) accounts for 2-3% of all central nervous system (CNS) tumors, predominantly affecting supratentorial sites in adult patients. In the present study, the immunohistochemical (IHC) profile…
View article: MTAP and p16 as immunohistochemical surrogates of CDKN2A/B homozygous deletion in central nervous system tumors: A multicentre Italian experience
MTAP and p16 as immunohistochemical surrogates of CDKN2A/B homozygous deletion in central nervous system tumors: A multicentre Italian experience Open
MTAP immunohistochemistry, alone or combined with p16, represents a cost-effective and feasible surrogate for detecting CDKN2A/B homozygous deletion in CNS tumors and provides relevant prognostic information.
View article: Roles for epigenetic and other biomarkers in upper tract urothelial carcinoma diagnosis and surveillance
Roles for epigenetic and other biomarkers in upper tract urothelial carcinoma diagnosis and surveillance Open
Upper tract urothelial carcinoma (UTUC) is a rare but aggressive malignancy with increasing incidence, often diagnosed at advanced stages due to the limitations of current diagnostic tools. Conventional methods such as urinary cytology, im…
View article: CUPROPTOSIS: A REVIEW ON MECHANISMS, ROLE IN SOLID AND HEMATOLOGICAL TUMORS, AND ASSOCIATION WITH VIRAL INFECTIONS
CUPROPTOSIS: A REVIEW ON MECHANISMS, ROLE IN SOLID AND HEMATOLOGICAL TUMORS, AND ASSOCIATION WITH VIRAL INFECTIONS Open
Cuproptosis is a distinct modality of regulated cell death precipitated by an overload of intracellular copper, critically dependent on mitochondrial respiration. The underlying mechanism involves the direct interaction of copper ions with…
View article: Gleason score down and upgrading at radical prostatectomy in targeted vs. systematic prostate biopsy: Findings from an institutional cohort
Gleason score down and upgrading at radical prostatectomy in targeted vs. systematic prostate biopsy: Findings from an institutional cohort Open
Our study highlights potential downgrading risk associated with TPBx alone, particularly in patients with initial GS of 4 + 4/GG4. While this has minimal implications for high-risk PCa, it raises concerns about potential overdiagnosis and …
View article: Understanding Neovascularization in Glioblastoma: Insights from the Current Literature
Understanding Neovascularization in Glioblastoma: Insights from the Current Literature Open
Glioblastomas (GBMs), among the most aggressive and resilient brain tumors, characteristically exhibit high angiogenic potential, leading to the formation of a dense yet aberrant vasculature, both morphologically and functionally. With the…
View article: PD-L1 expression in prostate cancer and Gleason Grade Group: Is there any relationship? Findings from a multi-institutional cohort.
PD-L1 expression in prostate cancer and Gleason Grade Group: Is there any relationship? Findings from a multi-institutional cohort. Open
Our study highlights a positive correlation between PD-L1 expression and GG in PCa, suggesting that higher PD-L1 expression is linked to more aggressive disease. This finding could have implications for treatment selection and the use of i…
View article: InterobServer AgreeMent in Pd‐l1 evaLuatIoN on cytoloGical samples—SAMPLING project: A multi‐institutional, international study
InterobServer AgreeMent in Pd‐l1 evaLuatIoN on cytoloGical samples—SAMPLING project: A multi‐institutional, international study Open
Introduction The aim of this project is to assess interobserver agreement for programmed death‐ligand 1 (PD‐L1) scoring on of non–small cell lung cancer (NSCLC) on cytological specimens in a large‐scale multicenter study, by exploiting the…
View article: Roles for Androgen Receptor, ADAR2, and PD-L1 in Primary Urothelial Carcinoma In Situ of the Bladder Treated with Bacillus Calmette–Guérin Therapy
Roles for Androgen Receptor, ADAR2, and PD-L1 in Primary Urothelial Carcinoma In Situ of the Bladder Treated with Bacillus Calmette–Guérin Therapy Open
In this retrospective observational multicenter study, we identified tumors and immune markers that are related to each other, which could help in selecting patients with bladder primary urothelial carcinoma in situ (CIS) who responded bet…
View article: Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance
Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance Open
Colorectal cancer (CRC) is a devastating disease, ranking as the second leading cause of cancer-related deaths worldwide. Immune checkpoint inhibitors (ICIs) have emerged as promising treatments; however, their efficacy is largely restrict…
View article: Immunoexpression of autophagy‑related proteins in a single‑center series of sporadic adult conventional clival chordomas
Immunoexpression of autophagy‑related proteins in a single‑center series of sporadic adult conventional clival chordomas Open
Autophagy is a biological process that facilitates the degradation and removal of damaged structures and macromolecules. In neoplasms, autophagy has been proposed to play a dual role, functioning either as a tumor promoter or a tumor suppr…
View article: N‐Acetyl‐L‐Cysteine (<scp>NAC</scp>) Blunts Axitinib‐Related Adverse Effects in Preclinical Models of Glioblastoma
N‐Acetyl‐L‐Cysteine (<span>NAC</span>) Blunts Axitinib‐Related Adverse Effects in Preclinical Models of Glioblastoma Open
Objective Axitinib is a tyrosine kinase inhibitor characterized by a strong affinity for Vascular Endothelial Growth Factor Receptors (VEGFRs). It was approved in 2012 by Food and Drug Administration and European Medicines Agency as a seco…
View article: Histologic Evaluation of Thyroid Nodules Treated with Thermal Ablation: An Institutional Experience
Histologic Evaluation of Thyroid Nodules Treated with Thermal Ablation: An Institutional Experience Open
Thyroid nodules are a common, benign condition with a higher prevalence in women, individuals with iodine deficiency, and radiation exposure. Treatment options for benign thyroid nodules include pharmaceutical therapy, thyroidectomy, and t…
View article: The Simultaneous Use of Bladder Epicheck® and Urinary Cytology Can Improve the Sensitivity and Specificity of Diagnostic Follow-Up of Urothelial Lesions: Up-to-Date Data from a Multi-Institutional Cohort
The Simultaneous Use of Bladder Epicheck® and Urinary Cytology Can Improve the Sensitivity and Specificity of Diagnostic Follow-Up of Urothelial Lesions: Up-to-Date Data from a Multi-Institutional Cohort Open
Background/Objectives: Bladder cancer is a prevalent urinary system malignancy and urinary cytology is widely used for its screening and follow-up. A novel diagnostic tool called Bladder Epicheck® (BE) is increasingly being used for monito…
View article: A preliminary study on the diagnostic performance of the uPath PD-L1 (SP263) artificial intelligence (AI) algorithm in patients with NSCLC treated with PD-1/PD-L1 checkpoint blockade
A preliminary study on the diagnostic performance of the uPath PD-L1 (SP263) artificial intelligence (AI) algorithm in patients with NSCLC treated with PD-1/PD-L1 checkpoint blockade Open
This preliminary analysis suggests that AI-based, digital pathology tools such as uPath PD-L1 (SP263) can be used to optimize already available biomarkers for immune-oncology treatment in patients with NSCLC.
View article: Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance
Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance Open
Colorectal Cancer (CRC) is a devastating disease, ranking second in cancer-related deaths. Immune checkpoint inhibitors (ICIs) have reshaped the prognosis of many cancers, including Microstatellite Instable (MSI) CRC. However, a significan…
View article: Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications
Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications Open
The management of advanced bladder carcinoma involves a multidisciplinary approach, but the prognosis remains poor for many patients. The immune system plays a crucial role in this disease, influencing both tumor development and response t…
View article: Role of IL-33/ST2 Pathway in Inflammatory Bowel Disease: An Overview and Future Perspectives
Role of IL-33/ST2 Pathway in Inflammatory Bowel Disease: An Overview and Future Perspectives Open
Inflammatory bowel disease (IBD) represents a heterogenous and complex group of idiopathic chronic inflammatory conditions affecting the gastrointestinal tract and other extraintestinal systems with rising global incidences. The interplay …
View article: Role of Multiparametric Magnetic Resonance Imaging and Targeted Biopsy in the Detection of Clinically Significant Prostate Cancer in Patients with Suspicious Digital Rectal Examination
Role of Multiparametric Magnetic Resonance Imaging and Targeted Biopsy in the Detection of Clinically Significant Prostate Cancer in Patients with Suspicious Digital Rectal Examination Open
Objectives: Few studies have examined the role of prostate MRI in patients with suspicious digital rectal examination (DRE) and/or PSA > 10 ng/mL. In a cohort of non-screened patients with suspicious DRE, we investigated the rate of avoida…
View article: The Morphology of Nasal Polyps in Different Age Groups: Histopathological Features
The Morphology of Nasal Polyps in Different Age Groups: Histopathological Features Open
Background: Nasal polyps (NPs) represent the end-stage manifestation of chronic rhinosinusitis (CRS), a relatively common pathological condition encountered in all ages of life. Methodology: The aim of our study was to evaluate the histolo…
View article: Digital Pathology Applications for PD-L1 Scoring in Head and Neck Squamous Cell Carcinoma: A Challenging Series
Digital Pathology Applications for PD-L1 Scoring in Head and Neck Squamous Cell Carcinoma: A Challenging Series Open
The assessment of programmed death-ligand 1 (PD-L1) combined positive scoring (CPS) in head and neck squamous cell carcinoma (HNSCC) is challenged by pre-analytical and inter-observer variabilities. An educational program to compare the di…
View article: Pilocytic astrocytoma: The paradigmatic entity in low‑grade gliomas (Review)
Pilocytic astrocytoma: The paradigmatic entity in low‑grade gliomas (Review) Open
Among low-grade gliomas, representing 10-20% of all primary brain tumours, the paradigmatic entity is constituted by pilocytic astrocytoma (PA), considered a grade 1 tumour by the World Health Organization. Generally, this tumour requires …
View article: Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer Open
Background About 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need for the development of innovative therapies. In this direction, the potential research focu…
View article: Immunohistochemical Profile of p62/SQSTM1/Sequestosome‐1 in Human Low‐ and High‐Grade Intracranial Meningiomas
Immunohistochemical Profile of p62/SQSTM1/Sequestosome‐1 in Human Low‐ and High‐Grade Intracranial Meningiomas Open
Among autophagic‐related proteins, p62/SQSTM1/Sequestosome‐1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplas…
View article: Methylation Analysis of Urinary Sample in Non-Muscle-Invasive Bladder Carcinoma: Frequency and Management of Invalid Result
Methylation Analysis of Urinary Sample in Non-Muscle-Invasive Bladder Carcinoma: Frequency and Management of Invalid Result Open
Background: Numerous studies showed that methylation analysis represents a newly developed urinary marker based on DNA methylation changes in a panel of genomic biomarkers and it could represent a valid tool in terms of the diagnosis and p…
View article: Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours
Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours Open