Maurizio Poli
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View article: Impact of health education on knowledge and perception of cervical cancer and screening among rural women in Bangladesh
Impact of health education on knowledge and perception of cervical cancer and screening among rural women in Bangladesh Open
Cervical cancer is the second most common cancer among women worldwide, causing nearly half of all diagnosed cases to result in death. Most of the cases, women are dying due to ignorance and lack of adequate knowledge, which is completely …
View article: Evidence-Based Reporting in Preimplantation Genetic Testing (PGT)
Evidence-Based Reporting in Preimplantation Genetic Testing (PGT) Open
Preimplantation genetic testing (PGT) reports play a decisive role in determining the fate of IVF-generated embryos. The identification of a chromosomal or genetic abnormality that could impact the health of the resulting newborn often lea…
View article: Traditional medicine use and associated factors in chronic patients in Jamalpur, Bangladesh: a cross-sectional study
Traditional medicine use and associated factors in chronic patients in Jamalpur, Bangladesh: a cross-sectional study Open
Background The history of traditional medicine is extensive. While modern medicine is commonly used to treat chronic illness, traditional medicine (TM) is gaining popularity as a healthcare practice in Bangladesh. However, evidence regardi…
View article: Preconception carrier screening and preimplantation genetic testing in the infertility management
Preconception carrier screening and preimplantation genetic testing in the infertility management Open
Background Genetic testing serves as a valuable element of reproductive care, applicable at various stages of the reproductive journey: (i) before pregnancy, when a couple's genetic reproductive risk can be evaluated; (ii) before embryo im…
View article: Residential exposure to magnetic fields from transformer stations and risk of childhood leukemia
Residential exposure to magnetic fields from transformer stations and risk of childhood leukemia Open
While we found no overall association between residential proximity to transformer stations and childhood leukemia, there was some evidence for elevated risk of childhood leukemia among children aged ≥5 years. Precision was limited by the …
View article: Residential exposure to magnetic fields from high-voltage power lines and risk of childhood leukemia
Residential exposure to magnetic fields from high-voltage power lines and risk of childhood leukemia Open
In this Italian population, close proximity to high-voltage power lines was associated with an excess risk of childhood leukemia.
View article: O-193 Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis
O-193 Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis Open
Study question What are the embryonic, maternal, paternal, clinical and laboratory features associated with the live-birth-rate (LBR) after euploid blastocyst transfer? Summary answer Delayed blastulation, poor blastocyst quality, maternal…
View article: O-302 Triploid conceptions are predominantly caused by female meiosis II errors and their risk increases with advancing maternal age
O-302 Triploid conceptions are predominantly caused by female meiosis II errors and their risk increases with advancing maternal age Open
Study question What are the incidence and origin of ploidy abnormalities in embryos derived from 2 pronuclei (2PN) zygotes, and is their risk linked to maternal age? Summary answer While embryo haploidy is usually due to male meiosis error…
View article: P-273 Heavy oil and conventional mineral oil produce similar Day 5 embryological outcomes. A prospective, single centre case study on 546 sibling 2PN zygotes
P-273 Heavy oil and conventional mineral oil produce similar Day 5 embryological outcomes. A prospective, single centre case study on 546 sibling 2PN zygotes Open
Study question Does heavy oil improve embryological outcomes compared to conventional mineral oil? Summary answer Heavy oil produces no improvement in embryological outcomes. What is known already Oil overlays are integral part of the cult…
View article: O-077 Time-lapse imaging analysis of segmental aneuploid embryos: a multicenter study identifies morpho-kinetic patterns associated with chromosomal mosaicism
O-077 Time-lapse imaging analysis of segmental aneuploid embryos: a multicenter study identifies morpho-kinetic patterns associated with chromosomal mosaicism Open
Study question Do segmental aneuploid (SA) embryos display unique morpho-kinetic patterns at early developmental stages? Summary answer The first three cell division cycles of embryos carrying segmental aneuploidies are significantly slowe…
View article: O-210 Detection of small copy number variations as incidental findings in PGT-A: clinical utility from a multisite experience including 12,157 patients
O-210 Detection of small copy number variations as incidental findings in PGT-A: clinical utility from a multisite experience including 12,157 patients Open
Study question What is the technical accuracy and clinical utility of reporting small copy number variants (CNVs below 3Mb) detected by a targeted next-generation sequencing-based PGT-A platform? Summary answer Some pathogenic or likely pa…
View article: O-289 Morphology should be prioritised over presumed mosaicism status in PGT-A cycles: data from a non-selection study of 2,621 embryo transfers
O-289 Morphology should be prioritised over presumed mosaicism status in PGT-A cycles: data from a non-selection study of 2,621 embryo transfers Open
Study question Is morphological grade or presumed low-mosaicism status the most impactful parameter on live birth rate (LBR) when selecting the embryo to transfer in PGT-A cycles? Summary answer Among euploid/presumed low-mosaic embryos, m…
View article: Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis
Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis Open
BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo implantation. Yet, its positive predictive value is not higher than 50…
View article: Residential exposure to magnetic fields from high-voltage power lines and risk of childhood leukemia in an Italian population
Residential exposure to magnetic fields from high-voltage power lines and risk of childhood leukemia in an Italian population Open
Background: An excess risk of leukemia in children living close to high-voltage power-lines and therefore exposed to extremely low frequency magnetic fields has been suggested, though not all studies yielded consistent results, and a possi…
View article: The human periconceptional maternal-embryonic space in health and disease
The human periconceptional maternal-embryonic space in health and disease Open
Pregnancy is established during the periconceptional period as a continuum beginning with blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and placenta formation. This period sets the foundation for t…
View article: Short-term effectiveness of dapagliflozin versus DPP-4 inhibitors in elderly patients with type 2 diabetes: a multicentre retrospective study
Short-term effectiveness of dapagliflozin versus DPP-4 inhibitors in elderly patients with type 2 diabetes: a multicentre retrospective study Open
View article: On the reproductive capabilities of aneuploid human preimplantation embryos
On the reproductive capabilities of aneuploid human preimplantation embryos Open
View article: Molecular tools for the genomic assessment of oocyte’s reproductive competence
Molecular tools for the genomic assessment of oocyte’s reproductive competence Open
View article: A standardized approach for case selection and genomic data analysis of maternal exomes for the diagnosis of oocyte maturation and early embryonic developmental arrest in IVF
A standardized approach for case selection and genomic data analysis of maternal exomes for the diagnosis of oocyte maturation and early embryonic developmental arrest in IVF Open
OBJECTIVE To develop a methodology for case selection and whole-exome sequencing (WES) analysis in infertile women due to recurrent oocyte maturation defects(OOMD) and/or preimplantation embryo lethality (PREMBL). DESIGN Retrospective coho…
View article: Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial
Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial Open
View article: Oocyte Cryopreservation at a Young Age Provides an Effective Strategy for Expanding Fertile Lifespan
Oocyte Cryopreservation at a Young Age Provides an Effective Strategy for Expanding Fertile Lifespan Open
With an upward trend in delaying parenthood, women across the world face an increasing risk of age-related infertility and involuntary childlessness. Elective oocyte banking strategies offer women the possibility to protect part of their r…
View article: Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population
Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population Open
STUDY QUESTION What is the clinical validity and utility of preconception Expanded Carrier Screening (ECS) application on the management of prospective parents? SUMMARY ANSWER The high detection rate of at-risk couples (ARCs) and the high …
View article: A prospective double-blinded non-selection trial of reproductive outcomes and chromosomal normalcy of newborns derived from putative low/moderate-degree mosaic IVF embryos
A prospective double-blinded non-selection trial of reproductive outcomes and chromosomal normalcy of newborns derived from putative low/moderate-degree mosaic IVF embryos Open
Background Next generation sequencing (NGS) has increased detection sensitivity of intermediate chromosome copy number variations (CNV) consistent with chromosomal mosaicism. Recently, this methodology has found application in preimplantat…
View article: Misreporting published data is not the way forward for a constructive scientific debate
Misreporting published data is not the way forward for a constructive scientific debate Open
View article: Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos
Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos Open
View article: Preimplantation Genetic Testing for Aneuploidy Improves Clinical, Gestational, and Neonatal Outcomes in Advanced Maternal Age Patients Without Compromising Cumulative Live-Birth Rate.
Preimplantation Genetic Testing for Aneuploidy Improves Clinical, Gestational, and Neonatal Outcomes in Advanced Maternal Age Patients Without Compromising Cumulative Live-Birth Rate. Open
View article: Predictors of early discontinuation of dapagliflozin versus other glucose-lowering medications: a retrospective multicenter real-world study
Predictors of early discontinuation of dapagliflozin versus other glucose-lowering medications: a retrospective multicenter real-world study Open
View article: Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age Open
Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitocho…
View article: Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions
Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions Open
View article: Comparative Effectiveness of DPP-4 Inhibitors Versus Sulfonylurea for the Treatment of Type 2 Diabetes in Routine Clinical Practice: A Retrospective Multicenter Real-World Study
Comparative Effectiveness of DPP-4 Inhibitors Versus Sulfonylurea for the Treatment of Type 2 Diabetes in Routine Clinical Practice: A Retrospective Multicenter Real-World Study Open