Mauro Agostino Zordan
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View article: A Syntaxin1A protein mutation drives sleep reduction in <i>Drosophila</i>
A Syntaxin1A protein mutation drives sleep reduction in <i>Drosophila</i> Open
SUMMARY Syntaxin1A is a key component in the regulation of the vesicle fusion nanomachine and, together with VAMP/synaptobrevin and SNAP-25, forms the core of the SNARE complex, that is the molecular nanomachine regulating neurotransmitter…
View article: Optokinetic response in D. melanogaster reveals the nature of common repellent odorants
Optokinetic response in D. melanogaster reveals the nature of common repellent odorants Open
View article: Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson’s disease
Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson’s disease Open
PD is a complex, multifactorial neurodegenerative disease, which occurs sporadically in aged population, with some genetically linked cases. Patients develop a very obvious locomotor phenotype, with symptoms such as bradykinesia, resting t…
View article: Optokinetic response in<i>D. Melanogaster</i>reveals the nature of common repellent odorants
Optokinetic response in<i>D. Melanogaster</i>reveals the nature of common repellent odorants Open
Animals’ ability to orient and navigate relies on selecting an appropriate motor response based on the perception and integration of the environmental information. This is the case, for instance, of the optokinetic response (OKR) in Drosop…
View article: DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster Open
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several neurodegenerative d…
View article: Lifespan and ROS levels in different <i>Drosophila melanogaster</i> strains after 24 h hypoxia exposure
Lifespan and ROS levels in different <i>Drosophila melanogaster</i> strains after 24 h hypoxia exposure Open
During recent decades, model organisms such as Drosophila melanogaster have made it possible to study the effects of different environmental oxygen conditions on lifespan and oxidative stress. However, many studies have often yielded contr…
View article: Dopamine Modulation of Drosophila Ellipsoid Body Neurons, a Nod to the Mammalian Basal Ganglia
Dopamine Modulation of Drosophila Ellipsoid Body Neurons, a Nod to the Mammalian Basal Ganglia Open
The central complex (CX) is a neural structure located on the midline of the insect brain that has been widely studied in the last few years. Its role in navigation and goal-oriented behaviors resembles those played by the basal ganglia in…
View article: A heuristic underlies the search for relief in <i>Drosophila melanogaster</i>
A heuristic underlies the search for relief in <i>Drosophila melanogaster</i> Open
Humans rely on multiple types of sensory information to make decisions, and strategies that shorten decision‐making time by taking into account fewer but essential elements of information are preferred to strategies that require complex an…
View article: Author response for "A heuristic underlies the search for relief in Drosophila melanogaster"
Author response for "A heuristic underlies the search for relief in Drosophila melanogaster" Open
View article: The impact of macroeconomic factors on suicide in 175 countries over 27 years
The impact of macroeconomic factors on suicide in 175 countries over 27 years Open
Background Every year, more than 800,000 people die by suicide, three‐quarters of which are males. Economic factors influence suicide rates, but a worldwide perspective of their impact according to age and sex is lacking. Method We queried…
View article: Students’ mental health problems before, during, and after COVID-19 lockdown in Italy
Students’ mental health problems before, during, and after COVID-19 lockdown in Italy Open
View article: A heuristic underlies the search for relief in fruit flies
A heuristic underlies the search for relief in fruit flies Open
Humans rely on multiple systems of sensory information to make decisions. However, strategies that shorten decision-making time by taking into account fewer but more essential elements of information are preferred to strategies involving c…
View article: Searching for relief: Drosophila melanogaster navigation in a virtual bitter maze
Searching for relief: Drosophila melanogaster navigation in a virtual bitter maze Open
View article: Data for: Searching for relief: Drosophila melanogaster navigation in a virtual bitter maze
Data for: Searching for relief: Drosophila melanogaster navigation in a virtual bitter maze Open
Dataframes (RDA) and scripts for data analysis (R) of the MS entitled "Searching for relief: Drosophila melanogaster navigation in a virtual bitter maze". Comments on R scripts will provide a step-by-step guide to data analysis. "BitterPla…
View article: Action-based attention in <i>Drosophila melanogaster</i>
Action-based attention in <i>Drosophila melanogaster</i> Open
The mechanism of action selection is a widely shared fundamental process required by animals to interact with the environment and adapt to it. A key step in this process is the filtering of the “distracting” sensory inputs that may disturb…
View article: Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back
Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back Open
Clinical and research studies have suggested a link between Parkinson’s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.…
View article: Mechanisms of selection for the control of action in<i>Drosophila melanogaster</i>
Mechanisms of selection for the control of action in<i>Drosophila melanogaster</i> Open
In the last few years several studies have investigated the neural mechanisms underlying spatial orientation in Drosophila melanogaster . Convergent results suggest that this mechanism is associated with specific neural circuits located wi…
View article: Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?
Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say? Open
There is evidence of a link between the circadian system and psychiatric diseases. Studies in humans and mammals suggest that environmental and/or genetic disruption of the circadian system leads to an increased liability to psychiatric di…