Mauro Biffoni
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View article: DUSP8 as a regulator of glioblastoma stem-like cell contribution to tumor vascularization
DUSP8 as a regulator of glioblastoma stem-like cell contribution to tumor vascularization Open
Glioblastomas (GBMs) are highly vascularized cancers. Transdifferentiation of GBM stem-like cells (GSCs) into GSC-derived endothelial cells (GdECs) contributes to GBM neovascularization. To dissect the molecular mechanisms and the signalin…
View article: Genomically matched therapy in advanced solid tumors: the randomized phase 2 ROME trial
Genomically matched therapy in advanced solid tumors: the randomized phase 2 ROME trial Open
View article: Long-term mortality and hospitalisation among Italian veterans deployed to the Balkans: a retrospective longitudinal study based on individual linkage with national health data
Long-term mortality and hospitalisation among Italian veterans deployed to the Balkans: a retrospective longitudinal study based on individual linkage with national health data Open
Introduction The potential health risks among veterans deployed to the Balkans have long been debated internationally. In Italy concern about cancer risk in veterans deployed to the Balkans in 1995–2004 (SEBAL cohort) originated from an in…
View article: Capsaicin and Its Combination with Oleic Acid Affect Membrane Fatty Acid Remodeling and Cytokine–Chemokine Secretion in HepG2 Cells
Capsaicin and Its Combination with Oleic Acid Affect Membrane Fatty Acid Remodeling and Cytokine–Chemokine Secretion in HepG2 Cells Open
Capsaicin, the main pungent component of chili peppers, exhibits several bioactive properties, such as modulation of adipogenesis and inhibition of liver steatosis by reducing cytoplasmic lipid accumulation. However, no evidence is current…
View article: The Impact of Concordance between Liquid and Tissue Biopsy for Actionable Mutations: Insights from the ROME Trial
The Impact of Concordance between Liquid and Tissue Biopsy for Actionable Mutations: Insights from the ROME Trial Open
Purpose: This analysis evaluated the influence of tissue and liquid biopsy concordance on outcomes in patients enrolled in the ROME trial. Patients and Methods: The ROME trial, a phase II multicenter study, enrolled 1,794 patients with adv…
View article: 15P The ROME trial: Personalized target therapy and immunotherapy in the breast cancer subgroup
15P The ROME trial: Personalized target therapy and immunotherapy in the breast cancer subgroup Open
View article: 95O Atezolizumab plus ipatasertib shows promise in extending survival for patients with PI3K/AKT/PTEN-altered advanced solid tumors: An exploratory analysis of the ROME trial
95O Atezolizumab plus ipatasertib shows promise in extending survival for patients with PI3K/AKT/PTEN-altered advanced solid tumors: An exploratory analysis of the ROME trial Open
View article: E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration
E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration Open
Background Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher preva…
View article: Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B Open
View article: Advancements in 3D In Vitro Models for Colorectal Cancer
Advancements in 3D In Vitro Models for Colorectal Cancer Open
The process of drug discovery and pre‐clinical testing is currently inefficient, expensive, and time‐consuming. Most importantly, the success rate is unsatisfactory, as only a small percentage of tested drugs are made available to oncologi…
View article: Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment
Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment Open
Background Glioblastoma (GBM) is the most lethal primary brain tumor in adult, characterized by highly aggressive and infiltrative growth. The current therapeutic management of GBM includes surgical resection followed by ionizing radiation…
View article: MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance
MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance Open
View article: <scp>CD8</scp>+<scp>CD103</scp>+<scp>PD1</scp>+<scp>TIM3</scp>+ T cells in glioblastoma microenvironment correlate with prognosis
<span>CD8</span>+<span>CD103</span>+<span>PD1</span>+<span>TIM3</span>+ T cells in glioblastoma microenvironment correlate with prognosis Open
Glioblastoma, isocitrate dehydrogenase‐wildtype (GB), is the most common and aggressive primary brain malignancy with poor outcome. Immune checkpoint inhibitors (ICIs) have been tested in GB and, despite disappointing results, the identifi…
View article: Correction to: L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fbrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients
Correction to: L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fbrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients Open
View article: CD8+CD103+PD1+TIM3+ T cells in glioblastoma microenvironment correlate with prognosis.
CD8+CD103+PD1+TIM3+ T cells in glioblastoma microenvironment correlate with prognosis. Open
Glioblastoma (GBM) is the most common and aggressive brain tumor with poor outcome. Immune checkpoint inhibitors (ICIs) have been tested in GBM and, despite disappointing results, the identification of a small subgroup of responders underl…
View article: L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients
L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients Open
View article: The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8) Open
Apoptosis is a tightly controlled cell death program executed by proteases, the so-called caspases. It plays an important role in tissue homeostasis and is often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes mi…
View article: NextGEM: Next-Generation Integrated Sensing and Analytical System for Monitoring and Assessing Radiofrequency Electromagnetic Field Exposure and Health
NextGEM: Next-Generation Integrated Sensing and Analytical System for Monitoring and Assessing Radiofrequency Electromagnetic Field Exposure and Health Open
The evolution of emerging technologies that use Radio Frequency Electromagnetic Field (RF-EMF) has increased the interest of the scientific community and society regarding the possible adverse effects on human health and the environment. T…
View article: Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Immunophenotypic characterization of lymphoid districts populations in WT or tumor-bearing Her2/neu transgenic mice, in the presence or absence of a functional IFN-I system
View article: Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Expression of putative CSC markers in neuT vs IFNAR-neuT tumors
View article: Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Type I interferon (IFN-I) is a class of antiviral immunomodulatory cytokines involved in many stages of tumor initiation and progression. IFN-I acts directly on tumor cells to inhibit cell growth and indirectly by activating immune cells t…
View article: Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Expression of putative CSC markers in neuT vs IFNAR-neuT tumors
View article: Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Immunophenotypic characterization of lymphoid districts populations in WT or tumor-bearing Her2/neu transgenic mice, in the presence or absence of a functional IFN-I system
View article: Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Kaplan-Meier showing RFS analysis of breast cancer patients divided by subtype according to IFNAR-neuT overexpressed genes
View article: Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Legends of supplementary figures
View article: Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Kaplan-Meier showing RFS analysis of breast cancer patients divided by subtype according to IFNAR-neuT overexpressed genes
View article: Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Tumor growth of neuT and IFNAR-neuT tumor cells transplanted subcutaneously in NSG mice
View article: Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Tumor growth of neuT and IFNAR-neuT tumor cells transplanted subcutaneously in NSG mice
View article: Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Type I interferon (IFN-I) is a class of antiviral immunomodulatory cytokines involved in many stages of tumor initiation and progression. IFN-I acts directly on tumor cells to inhibit cell growth and indirectly by activating immune cells t…
View article: Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Legends of supplementary figures