Explanipedia

Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind Open

Federico Frau, Marta Bosia, Luca Bischetti, Gloria Cappelli, Antonio Carotenuto , et al. · 2025

Pragmatic impairments are largely documented, yet rarely considered in clinical practice, also due to a poor characterization of pragmatic profiles across conditions, as well as some overlap with theory of mind (ToM) in the conceptualizati…

Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind Open

Federico Frau, Marta Bosia, Luca Bischetti, Gloria Cappelli, Antonio Carotenuto , et al. · 2025

Pragmatic impairments are largely documented, yet rarely considered in clinical practice, also due to a poor characterization of pragmatic profiles across conditions, as well as some overlap with theory of mind (ToM) in the conceptualizati…

Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind Open

Federico Frau, Marta Bosia, Luca Bischetti, Gloria Cappelli, Antonio Carotenuto , et al. · 2024

Pragmatic impairments are largely documented, yet rarely considered in clinical practice, also due to a poor characterization of pragmatic profiles across conditions, as well as some overlap with theory of mind (ToM) in the conceptualizati…

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data Open

Sara Sáez-Atiénzar, Cleide Dos Santos Souza, Ruth Chia, Selina N. Beal, Ileana Lorenzini , et al. · 2024

A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer’s Disease Open

Riccardo Rocco Ferrari, Valentina Fantini, Maria Garofalo, Rosalinda Di Gerlando, Francesca Dragoni , et al. · 2024

Alzheimer’s disease (AD) is a neurodegenerative disorder that progressively involves brain regions with an often-predictable pattern. Damage to the brain appears to spread and worsen with time, but the molecular mechanisms underlying the r…

Real-world use of oral versus subcutaneous semaglutide in a cohort of type 2 diabetic patients: which option to which patient? Open

Caterina Formichi, Walter Baronti, Giovanni Gennaro, Mauro Ceroni, Laura Nigi , et al. · 2024

Mechanism-Free Repurposing of Drugs For C9orf72-related ALS/FTD Using Large-Scale Genomic Data Open

Sara Sáez-Atiénzar, Cleide Dos Santos Souza, Ruth Chia, Selina N. Beal, Ileana Lorenzini , et al. · 2024

Mechanism-Free Repurposing of Drugs For C9orf72-Related ALS/FTD Using Large-Scale Genomic Data Open

Sara Sáez-Atiénzar, Cleide Dos Santos Souza, Ruth Chia, Selina N. Beal, Ileana Lorenzini , et al. · 2024

The decline of quantitative EEG goes along with neuropathology in Alzheimer’s Disease Open

Tino Emanuele Poloni, G Negro, Paola Cassini, Xhulja Profka, Michele Rossi , et al. · 2023

Background Few studies investigate the correlation between the quantitative EEG (QEEG) and the neuropathological picture. The purpose of this study is to explore how QEEG can recognize the type and extent of neuropathological changes. Meth…

Is QEEG an effective biomarker in predicting cognitive decline? Open

Valentina Medici, Paola Cassini, Michele Rossi, Laura Pettinato, G Negro , et al. · 2023

Background Alterations in EEG traces are observed in synaptic failure with a reduction in the background α rhythm and an increase in slow frequencies (θ‐δ). The aim of the study is to evaluate whether quantitative EEG (QEEG) can be a relia…

COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and Microthrombosis Open

Tino Emanuele Poloni, Matteo Moretti, Valentina Medici, Elvira Turturici, Giacomo Belli , et al. · 2022

Here, we aim to describe COVID-19 pathology across different tissues to clarify the disease’s pathophysiology. Lungs, kidneys, hearts, and brains from nine COVID-19 autopsies were compared by using antibodies against SARS-CoV-2, macrophage…

Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia Open

Ilaria Palmieri, Tino Emanuele Poloni, Valentina Medici, Susanna Zucca, Annalisa Davin , et al. · 2022

Alzheimer’s disease (AD) and Lewy body dementia (LBD) are two different forms of dementia, but their pathology may involve the same cortical areas with overlapping cognitive manifestations. Nonetheless, the clinical phenotype is different …

Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia Open

Ilaria Palmieri, Tino Emanuele Poloni, Valentina Medici, Susanna Zucca, Annalisa Davin , et al. · 2022

Background Alzheimer’s disease (AD) and Lewy body dementia (LBD) are two different forms of dementia, but their pathology may involve the same cortical areas with overlapping cognitive manifestation. Dementia cases within the same family s…

Extracellular Vesicles Derived From Plasma of Patients With Neurodegenerative Disease Have Common Transcriptomic Profiling Open

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini , et al. · 2022

Objectives There is a lack of effective biomarkers for neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia. Extracellular vesicle (EV…

The Problem of Consciousness: The Experiential Approach of Luigi Giussani and the Foundation of the Conception of Consciousness in Neuroscience Open

Mauro Ceroni · 2022

The relationship between consciousness and brain, subject and body, appears today far away from being elucidated. All attempts to reduce consciousness and subject to the brain end up abolishing the subject, i.e., what is evidently most rel…

Case Report: Laryngospasm as Initial Manifestation of Amyotrophic Lateral Sclerosis in a Long-Survival Patient With Heterozygous p.D90A – SOD1 Mutation Open

Giuliana Capece, Mauro Ceroni, Enrico Alfonsi, Ilaria Palmieri, Cristina Cereda , et al. · 2021

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Although its etiology is still unknown, many genes have been found to be implicated in ALS pathogenesis. The Cu/Zn superoxide dismutase ( SOD…

COVID-19 patients and Dementia: Frontal cortex transcriptomic data Open

Maria Garofalo, Stella Gagliardi, Susanna Zucca, Cecilia Pandini, Francesca Dragoni , et al. · 2021

Association of Variants in the <i>SPTLC1</i> Gene With Juvenile Amyotrophic Lateral Sclerosis Open

Janel O. Johnson, Ruth Chia, Danny E. Miller, Rachel Li, Ravindran Kumaran , et al. · 2021

These data broaden the phenotype associated with SPTLC1 and suggest that patients presenting with juvenile ALS should be screened for variants in this gene.

<span>Sars‐Cov</span>‐2 in a Patient with Acute Chorea: Innocent Bystander or Unexpected Actor? Open

Matteo Cotta Ramusino, Giulia Perini, Gabriele Corrao, Lisa Maria Farina, Giulia Berzero , et al. · 2021

Chorea mostly presents as a slow-course neurodegenerative disorder with a genetic cause (Huntington's disease). However, subacute-onset forms often have an organic (eg, vascular, infectious, paraneoplastic) or metabolic etiology.1, 2 Here …

COVID‐19‐related neuropathology and microglial activation in elderly with and without dementia Open

Tino Emanuele Poloni, Valentina Medici, Matteo Moretti, Silvia Damiana Visonà, A Cirrincione , et al. · 2021

The actual role of SARS‐CoV‐2 in brain damage remains controversial due to lack of matched controls. We aim to highlight to what extent is neuropathology determined by SARS‐CoV‐2 or by pre‐existing conditions. Findings of 9 Coronavirus dis…

Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patients Open

Stella Gagliardi, Tino Emanuele Poloni, Cecilia Pandini, Maria Garofalo, Francesca Dragoni , et al. · 2021

SARS-Cov-2 infection is frequently associated with Nervous System manifestations. However, it is not clear how SARS-CoV-2 can cause neurological dysfunctions and which molecular processes are affected in the brain. In this work, we examine…

Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases Open

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini , et al. · 2021

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in b…

Life during COVID-19 lockdown in Italy: the influence of cognitive state on psychosocial, behavioral and lifestyle profiles of older adults Open

Arenn F. Carlos, Tino Emanuele Poloni, Martina Caridi, Marco Pozzolini, Roberta Vaccaro , et al. · 2021

NOLD and mild-NCD groups showed similar mood-behavioral profiles suggesting better tolerance of lockdown. Those with dementia were unable to adapt and suffered from depression and cognitive complaints. To counteract lockdown effects, physi…

Frontal and Cerebellar Atrophy Supports FTSD-ALS Clinical Continuum Open

Beatrice Pizzarotti, Fulvia Palesi, Paolo Vitali, Gloria Castellazzi, Nicoletta Anzalone , et al. · 2020

Background Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic, and genetic perspectives. We used localized brain volum…

Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patients Open

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini , et al. · 2020

Background Identifying robust biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological function…

COVID-19 and Guillain–Barré Syndrome: A Case Report and Review of Literature Open

Antonio Zito, Enrico Alfonsi, Diego Franciotta, Massimiliano Todisco, Matteo Gastaldi , et al. · 2020

During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barré syndrome (GBS), 12 days after severe acute respir…

Prevalence and prognostic value of Delirium as the initial presentation of COVID-19 in the elderly with dementia: An Italian retrospective study Open

Tino Emanuele Poloni, Arenn F. Carlos, Marco Cairati, Chiara Cutaia, Valentina Medici , et al. · 2020

Mini Nutritional Assessment May Identify a Dual Pattern of Perturbed Plasma Amino Acids in Patients with Alzheimer’s Disease: A Window to Metabolic and Physical Rehabilitation? Open

Roberto Aquilani, Alfredo Costa, Roberto Maestri, Matteo Cotta Ramusino, Antonia Pierobon , et al. · 2020

Conflicting results about alterations of plasma amino acid (AA) levels are reported in subjects with Alzheimer’s disease (AD). The current study aimed to provide more homogeneous AA profiles and correlations between AAs and cognitive tests…

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains Open

Tino Emanuele Poloni, Valentina Medici, Arenn F. Carlos, Annalisa Davin, Arcangelo Ceretti , et al. · 2020

In a constantly aging population, the prevalence of neurodegenerative disorders is expected to rise. Understanding disease mechanisms is the key to find preventive and curative measures. The most effective way to achieve this is through di…

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