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View article: Integrating Radiomics and Artificial Intelligence (AI) in Stereotactic Body Radiotherapy (SBRT)/Stereotactic Radiosurgery (SRS): Predictive Tools for Tailored Cancer Care
Integrating Radiomics and Artificial Intelligence (AI) in Stereotactic Body Radiotherapy (SBRT)/Stereotactic Radiosurgery (SRS): Predictive Tools for Tailored Cancer Care Open
Purpose: This systematic review aims to analyze the literature on the application of AI in predicting patient outcomes and treatment-related toxicity in those undergoing SBRT or SRS across heterogeneous tumor sites. Materials and methods: …
View article: Early Results from a Randomized Phase II Trial Testing Apalutamide and Stereotactic Body Radiation Therapy for Low-Burden Mhspc (NCT05717660)
Early Results from a Randomized Phase II Trial Testing Apalutamide and Stereotactic Body Radiation Therapy for Low-Burden Mhspc (NCT05717660) Open
View article: Oligometastatic Mesothelioma Treated with Ablative Radiotherapy (OMAR): A Multicenter Study
Oligometastatic Mesothelioma Treated with Ablative Radiotherapy (OMAR): A Multicenter Study Open
Background/Objectives: This multicenter retrospective study aims to evaluate the role of Ablative Radiotherapy (RT) in patients with unresectable pleural mesothelioma (PM) who experienced radiological progression after at least one line of…
View article: Stereotactic Salvage Radiotherapy for Macroscopic Prostate Bed Recurrence After Prostatectomy: STARR (NCT05455736): An Early Analysis from the STARR Trial
Stereotactic Salvage Radiotherapy for Macroscopic Prostate Bed Recurrence After Prostatectomy: STARR (NCT05455736): An Early Analysis from the STARR Trial Open
Purpose/Objectives: Salvage radiotherapy (SRT) after a radical prostatectomy is a curative approach for patients with biochemical recurrence (BR). However, outcomes are often less favorable when imaging reveals macroscopic local recurrence…
View article: Ureter Tolerance in Patients Treated with Stereotactic Body Radiation Therapy on Abdominopelvic Lymph Nodes: Analysis on Dose-related Late Toxicity
Ureter Tolerance in Patients Treated with Stereotactic Body Radiation Therapy on Abdominopelvic Lymph Nodes: Analysis on Dose-related Late Toxicity Open
The incidence of G3 ureteral toxicity after SBRT on A-P LN oligometastases is low (2%). Published dose constraints were violated in 23% of the patients without reported toxicity, suggesting other factors may contribute. Furthermore, no dif…
View article: Multimodal treatment improves survival in patients with lung metastases from colorectal cancer: A network meta‐analysis
Multimodal treatment improves survival in patients with lung metastases from colorectal cancer: A network meta‐analysis Open
Aim The lungs represent the second most common site of colorectal cancer metastases. Although surgery is commonly considered the best treatment, many other invasive and noninvasive procedures and treatments have been adopted to improve pat…
View article: Recent Advances and Current Challenges in Stereotactic Body Radiotherapy for Ultra-Central Lung Tumors
Recent Advances and Current Challenges in Stereotactic Body Radiotherapy for Ultra-Central Lung Tumors Open
Stereotactic body radiotherapy has been established as a viable treatment option for inoperable early-stage non-small cell lung cancer or secondary lesions mainly in oligoprogressive/oligometastatic scenarios. Treating lesions in the so-ca…
View article: Recent Advances and Current Challenges in Stereotactic Body Radiotherapy for Ultra-Central Lung Tumors
Recent Advances and Current Challenges in Stereotactic Body Radiotherapy for Ultra-Central Lung Tumors Open
Stereotactic Body Radiotherapy has been established as a viable treatment option for inoperable early-stage Non-Small Cell Lung Cancer or secondary lesions mainly in oligoprogressive/oligometastatic scenarios. Treating lesions in the so-ca…
View article: STRILL: Phase I Trial Evaluating Stereotactic Body Radiotherapy (SBRT) Dose Escalation for Re-Irradiation of Inoperable Peripheral Lung Lesions
STRILL: Phase I Trial Evaluating Stereotactic Body Radiotherapy (SBRT) Dose Escalation for Re-Irradiation of Inoperable Peripheral Lung Lesions Open
Few data are available on the role of SBRT re-irradiation for isolated recurrences. We designed a prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation, for peripheral lung lesions. RT w…
View article: Radiomic Analysis for Human Papillomavirus Assessment in Oropharyngeal Carcinoma: Lessons and Pitfalls for the Next Future
Radiomic Analysis for Human Papillomavirus Assessment in Oropharyngeal Carcinoma: Lessons and Pitfalls for the Next Future Open
Background: Oropharyngeal Squamous Cell Carcinoma (OPSCC) is rapidly increasing due to the spread of Human Papillomavirus (HPV) infection. HPV-positive disease has unique characteristics, with better response to treatment and consequent be…
View article: The Role of Stereotactic Radiotherapy in Deferring the Need for Systemic Therapies in Patients with Progressive Oligometastatic Iodine-Refractory Thyroid Cancer
The Role of Stereotactic Radiotherapy in Deferring the Need for Systemic Therapies in Patients with Progressive Oligometastatic Iodine-Refractory Thyroid Cancer Open
View article: Preoperative Radiotherapy of Soft Tissue Sarcoma with Simultaneous Integrated Boost: A Phase II Study
Preoperative Radiotherapy of Soft Tissue Sarcoma with Simultaneous Integrated Boost: A Phase II Study Open
View article: Long Term Clinical Outcomes of a Cohort of Lung-Only Oligometastatic HNSCC Patients Treated with SBRT
Long Term Clinical Outcomes of a Cohort of Lung-Only Oligometastatic HNSCC Patients Treated with SBRT Open
View article: Ultra-Central Tumors Treated with Stereotactic Body Radiotherapy: Clinical Outcome and Prognostic Factors
Ultra-Central Tumors Treated with Stereotactic Body Radiotherapy: Clinical Outcome and Prognostic Factors Open
View article: Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO)
Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO) Open
PURPOSE ARTO (ClinicalTrials.gov identifier: NCT03449719 ) is a multicenter, phase II randomized clinical trial testing the benefit of adding stereotactic body radiation therapy (SBRT) to abiraterone acetate and prednisone (AAP) in patient…
View article: Modulation of tumor-associated macrophage activity with radiation therapy: a systematic review
Modulation of tumor-associated macrophage activity with radiation therapy: a systematic review Open
View article: Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
Combination treatment induces a long-term anti-metastatic immune response
View article: Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
Combination treatment induces a long-term anti-metastatic immune response
View article: Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
NG2 and ICAM-1 staining are increased by combined treatment
View article: Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
CTLA4, PD1 and Tim3 expression on CD8+ T cells is not modulated by combination treatment
View article: Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
KRN7000 adjuvant or low doses irradiation does not modify tumor response
View article: Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
CTLA4, PD1 and Tim3 expression on CD8+ T cells is not modulated by combination treatment
View article: Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
There is growing interest in the association of radiotherapy and immunotherapy for the treatment of solid tumors. Here, we report an extremely effective combination of local irradiation (IR) and Shiga Toxin B (STxB)–based human papillomavi…
View article: Supplementary Figure S4 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S4 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
Tumor vessels staining is not significantly affected by treatments
View article: Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
There is growing interest in the association of radiotherapy and immunotherapy for the treatment of solid tumors. Here, we report an extremely effective combination of local irradiation (IR) and Shiga Toxin B (STxB)–based human papillomavi…
View article: Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
NG2 and ICAM-1 staining are increased by combined treatment
View article: Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
KRN7000 adjuvant or low doses irradiation does not modify tumor response
View article: Supplementary Figure S4 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S4 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
Tumor vessels staining is not significantly affected by treatments
View article: Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results
Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results Open
PSICHE (NCT05022914) is a prospective trial to test a [ 68 Ga]Ga- PSMA-11 PET/CT imaging tailored strategy. All evaluable patients had biochemical relapse after surgery and underwent centralized [ 68 Ga]Ga-PSMA-11 PET/CT imaging. The treat…
View article: Systemic Inflammation and Lung Cancer: Is It a Real Paradigm? Prognostic Value of Inflammatory Indexes in Patients with Resected Non-Small-Cell Lung Cancer
Systemic Inflammation and Lung Cancer: Is It a Real Paradigm? Prognostic Value of Inflammatory Indexes in Patients with Resected Non-Small-Cell Lung Cancer Open
Background (1): Our goal was to investigate if and how pre-operative inflammatory status can influence the long-term prognosis of patients undergoing lung surgery for cancer. Materials and Methods (2): This prospective observational study …