Max A. Seibold
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View article: Independent and interactive effects of viral species on early-life lower respiratory tract illness
Independent and interactive effects of viral species on early-life lower respiratory tract illness Open
Diverse viral pathogens drive early-life sLRIs. Some (e.g. RSV and metapneumovirus) have an intrinsic propensity to cause sLRIs, while other viruses' lower airway pathogenicity depends on other factors, including co-infection.
View article: The common cold is associated with protection from SARS-CoV-2 Infections
The common cold is associated with protection from SARS-CoV-2 Infections Open
Background Adults and children often respond differently to SARS-CoV-2 infection, with adults facing a higher risk of symptomatic and severe illness. We hypothesize that children's protection from symptomatic SARS-CoV-2 may be due to more …
View article: Impact of nasal and inhaled corticosteroids on SARS-CoV-2 infection susceptibility
Impact of nasal and inhaled corticosteroids on SARS-CoV-2 infection susceptibility Open
View article: Impact of Insulin Concentrations and Insulin Resistance on Lung Function and Morbidity in Asthma
Impact of Insulin Concentrations and Insulin Resistance on Lung Function and Morbidity in Asthma Open
View article: The PRIMERO birth cohort: Design and baseline characteristics
The PRIMERO birth cohort: Design and baseline characteristics Open
The PRIMERO birth cohort study, with its comprehensive data on viral exposures, respiratory outcomes, and airway molecular phenotypes in a high-risk population of Puerto Rican children, is uniquely positioned to address long-standing quest…
View article: Independent and interactive effects of viral species on risk for lower respiratory tract illnesses in early life
Independent and interactive effects of viral species on risk for lower respiratory tract illnesses in early life Open
Importance All children experience upper respiratory tract illnesses (URI) caused by viral infections. However, some of these illnesses progress to the lower airways. Although studies have found infection with certain viral species are mor…
View article: Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children
Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children Open
Not applicable.
View article: Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children
Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children Open
View article: Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma
Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma Open
Rhinovirus C (RV-C) infection can trigger asthma exacerbations in children and adults, and RV-C-induced wheezing illnesses in preschool children correlate with the development of childhood asthma. Surfactant protein A (SP-A) plays a critic…
View article: 5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function
5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function Open
Background Previous research showed that 5-hydroxytryptophan (5HTP), a metabolic precursor of serotonin, reduces allergic lung inflammation by inhibiting eosinophil migration across endothelial monolayers. Objective It is unknown if seroto…
View article: Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods
Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods Open
The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and househ…
View article: A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma Open
View article: The Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes (PRIMERO): Design and Baseline Characteristics for a Birth Cohort Study of Early-life Viral Respiratory Illnesses and Airway Dysfunction in Puerto Rican Children
The Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes (PRIMERO): Design and Baseline Characteristics for a Birth Cohort Study of Early-life Viral Respiratory Illnesses and Airway Dysfunction in Puerto Rican Children Open
Epidemiologic studies demonstrate an association between early-life respiratory illnesses (RIs) and the development of childhood asthma. However, it remains uncertain whether these children are predisposed to both conditions or if early-li…
View article: Atopic Dermatitis Complicated by Recurrent Eczema Herpeticum Is Characterized by Multiple, Concurrent Epidermal Inflammatory Endotypes
Atopic Dermatitis Complicated by Recurrent Eczema Herpeticum Is Characterized by Multiple, Concurrent Epidermal Inflammatory Endotypes Open
View article: Maternal Transcriptomic Profiles and Phenotypes of Childhood Wheeze in the Breathe-Wellbeing, Environment, Lifestyle and Lung function (B-WELL-Mom) study
Maternal Transcriptomic Profiles and Phenotypes of Childhood Wheeze in the Breathe-Wellbeing, Environment, Lifestyle and Lung function (B-WELL-Mom) study Open
View article: Association of Early-life Daycare Exposure and Allergy Sensitization in Puerto Rico: PRIMERO Birth Cohort Findings
Association of Early-life Daycare Exposure and Allergy Sensitization in Puerto Rico: PRIMERO Birth Cohort Findings Open
View article: EARLY-LIFE LOWER RESPIRATORY ILLNESSES AND UNPLANNED CESAREAN DELIVERY IN PUERTO RICO: PRIMERO BIRTH COHORT FINDINGS
EARLY-LIFE LOWER RESPIRATORY ILLNESSES AND UNPLANNED CESAREAN DELIVERY IN PUERTO RICO: PRIMERO BIRTH COHORT FINDINGS Open
View article: Asthma severity and corticosteroid response depend on variable type 1 and type 2 inflammation in the airway
Asthma severity and corticosteroid response depend on variable type 1 and type 2 inflammation in the airway Open
The prevalence, inter-relationships, and longitudinal behavior of type 1 (T1) and type 2 (T2) immune responses in asthma are uncertain, as is the role of viruses as determinants of these responses. Here, we performed whole transcriptome ne…
View article: Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells Open
Background Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albut…
View article: 195 Sinonasal epithelial responses to long-term highly effective CFTR modulator therapy
195 Sinonasal epithelial responses to long-term highly effective CFTR modulator therapy Open
View article: Breathing zone pollutant levels are associated with asthma exacerbations in high-risk children
Breathing zone pollutant levels are associated with asthma exacerbations in high-risk children Open
Background Indoor and outdoor air pollution levels are associated with poor asthma outcomes in children. However, few studies have evaluated whether breathing zone pollutant levels associate with asthma outcomes. Objective Determine breath…
View article: An integrated cell atlas of the lung in health and disease
An integrated cell atlas of the lung in health and disease Open
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these lim…
View article: A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection Open
View article: Anionic Pulmonary Surfactant Lipid Treatment Inhibits Rhinovirus A Infection of the Human Airway Epithelium
Anionic Pulmonary Surfactant Lipid Treatment Inhibits Rhinovirus A Infection of the Human Airway Epithelium Open
Rhinoviruses (RVs) are major instigators of acute exacerbations of asthma, COPD, and other respiratory diseases. RVs are categorized into three species (RV-A, RV-B, and RV-C), which comprise more than 160 serotypes, making it difficult to …
View article: CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma
CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma Open
View article: Atopic dermatitis complicated by recurrent eczema herpeticum is characterized by multiple, concurrent epidermal inflammatory endotypes
Atopic dermatitis complicated by recurrent eczema herpeticum is characterized by multiple, concurrent epidermal inflammatory endotypes Open
BACKGROUND A subgroup of atopic dermatitis (AD) patients suffer from recurrent, disseminated herpes simplex virus (HSV) skin infections, termed eczema herpeticum (EH), which can be life-threatening and contribute to AD morbidity. The patho…
View article: IL-13–associated epithelial remodeling correlates with clinical severity in nasal polyposis
IL-13–associated epithelial remodeling correlates with clinical severity in nasal polyposis Open
View article: Effects of Worry About COVID-19 on Activities that Increase Risk of SARS-CoV-2 Infection in a 12-City Surveillance Study of Households with Children
Effects of Worry About COVID-19 on Activities that Increase Risk of SARS-CoV-2 Infection in a 12-City Surveillance Study of Households with Children Open
View article: IL-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis
IL-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis Open
Background Epithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell type shifts and their relationship to CRS endotypes and severity are incompletely described.…
View article: Author Correction: Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
Author Correction: Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology Open