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View article: Christian Bauer—physiologist, mentor, and philosopher
Christian Bauer—physiologist, mentor, and philosopher Open
View article: Health benefits of life at moderate altitude: does hypoxia matter?
Health benefits of life at moderate altitude: does hypoxia matter? Open
View article: Correction: Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells
Correction: Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells Open
[This corrects the article DOI: 10.1371/journal.pone.0275725.].
View article: Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1 axis
Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1 axis Open
View article: A Comprehensive Insight and In Silico Analysis of CircRNAs in Hepatocellular Carcinoma: A Step toward ncRNA-Based Precision Medicine
A Comprehensive Insight and In Silico Analysis of CircRNAs in Hepatocellular Carcinoma: A Step toward ncRNA-Based Precision Medicine Open
Circular RNAs (circRNAs) are cardinal players in numerous physiological and pathological processes. CircRNAs play dual roles as tumor suppressors and oncogenes in different oncological contexts, including hepatocellular carcinoma (HCC). Th…
View article: Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation
Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation Open
View article: Mechanisms underlying the health benefits of intermittent hypoxia conditioning
Mechanisms underlying the health benefits of intermittent hypoxia conditioning Open
Intermittent hypoxia (IH) is commonly associated with pathological conditions, particularly obstructive sleep apnoea. However, IH is also increasingly used to enhance health and performance and is emerging as a potent non‐pharmacological i…
View article: Swiss Parabolic Flights: Development of a Non-Governmental Parabolic Flight Program in Switzerland Based on the Airbus A310 ZERO-G
Swiss Parabolic Flights: Development of a Non-Governmental Parabolic Flight Program in Switzerland Based on the Airbus A310 ZERO-G Open
Parabolic flights are one of the most important pillars for research, development, and applications in space. Accordingly, we developed the world’s first non-governmental parabolic flight program using Novespace’s Airbus A310 ZERO-G. Throu…
View article: The Impact of Ca2+ on Intracellular Distribution of Hemoglobin in Human Erythrocytes
The Impact of Ca2+ on Intracellular Distribution of Hemoglobin in Human Erythrocytes Open
The membrane-bound hemoglobin (Hb) fraction impacts red blood cell (RBC) rheology and metabolism. Therefore, Hb–RBC membrane interactions are precisely controlled. For instance, the signaling function of membrane-bound deoxy-Hb and the str…
View article: Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis
Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis Open
Brown adipose tissue (BAT) plays an important role in energy homeostasis by generating heat from chemical energy via uncoupled oxidative phosphorylation. Besides its high mitochondrial content and its exclusive expression of the uncoupling…
View article: Expression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
Expression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation Open
View article: Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation
Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation Open
Myelination is a process that is tightly regulated by a variety of neurotrophic factors. Here, we show - by analyzing two transgenic mouse lines, one overexpressing EPO selectively in the brain Tg21 ( PDGFB-rhEPO ), and another with target…
View article: S287: HEMOGLOBIN AND FERRITIN LEVELS ADJUST DIFFERENTLY TO MODERATE AND HIGH ALTITUDE IN DIFFERENT WORLD REGIONS: EVIDENCE FOR A VERY PRECISE OXYGEN SENSING SYSTEM
S287: HEMOGLOBIN AND FERRITIN LEVELS ADJUST DIFFERENTLY TO MODERATE AND HIGH ALTITUDE IN DIFFERENT WORLD REGIONS: EVIDENCE FOR A VERY PRECISE OXYGEN SENSING SYSTEM Open
Background: About 7% of the world’s population lives more than 1500 meters above sea level (masl) and as a consequence, the hemoglobin (Hb) levels increase. We analyzed this increased in various regions of the globe. Aims: To define the Hb…
View article: Voluntary exercise does not always suppress lung cancer progression
Voluntary exercise does not always suppress lung cancer progression Open
View article: The Brain at High Altitude: From Molecular Signaling to Cognitive Performance
The Brain at High Altitude: From Molecular Signaling to Cognitive Performance Open
The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive proces…
View article: Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice
Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice Open
View article: Supplementary Tables 1-3, Figures 1-3 from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes
Supplementary Tables 1-3, Figures 1-3 from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes Open
PDF file - 347K
View article: Data from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Data from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression Open
Hypoxia-inducible factor 1 (HIF-1) is the key transcription factor regulating hypoxia-dependent gene expression. Lack of oxygen stabilizes HIF-1, which in turn modulates the gene expression pattern to adapt cells to the hypoxic environment…
View article: Supplementary Tables 1-3, Figures 1-3 from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes
Supplementary Tables 1-3, Figures 1-3 from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes Open
PDF file - 347K
View article: Data from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes
Data from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes Open
Rampant activity of the hypoxia-inducible factor (HIF)-1 in cancer is frequently associated with the malignant progression into a harder-to-treat, increasingly aggressive phenotype. Clearly, anti-HIF strategies in cancer cells are of consi…
View article: Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression Open
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
View article: Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression Open
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
View article: Data from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Data from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression Open
Hypoxia-inducible factor 1 (HIF-1) is the key transcription factor regulating hypoxia-dependent gene expression. Lack of oxygen stabilizes HIF-1, which in turn modulates the gene expression pattern to adapt cells to the hypoxic environment…
View article: Data from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes
Data from Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes Open
Rampant activity of the hypoxia-inducible factor (HIF)-1 in cancer is frequently associated with the malignant progression into a harder-to-treat, increasingly aggressive phenotype. Clearly, anti-HIF strategies in cancer cells are of consi…
View article: The Increase in Hemoglobin Concentration With Altitude Differs Between World Regions and Is Less in Children Than in Adults
The Increase in Hemoglobin Concentration With Altitude Differs Between World Regions and Is Less in Children Than in Adults Open
To compensate for decreased oxygen partial pressure, high-altitude residents increase hemoglobin concentrations [Hb]. The elevation varies between world regions, posing problems in defining cutoff values for anemia or polycythemia. The cur…
View article: Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress
Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress Open
Hypoxia is increasingly recognized as an important physiological driving force. A specific transcriptional program, induced by a decrease in oxygen (O 2 ) availability, for example, inspiratory hypoxia at high altitude, allows cells to ada…
View article: Voluntary Exercise Does Not Always Suppress Lung Cancer Progression
Voluntary Exercise Does Not Always Suppress Lung Cancer Progression Open
View article: Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells
Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells Open
Myoglobin (MB) is known to bind and deliver oxygen in striated muscles at high expression levels. MB is also expressed at much reduced levels in mammary epithelial cells, where the protein´s function is unclear. In this study, we aim to de…
View article: Pro-Apoptotic and Anti-Invasive Properties Underscore the Tumor-Suppressing Impact of Myoglobin on a Subset of Human Breast Cancer Cells
Pro-Apoptotic and Anti-Invasive Properties Underscore the Tumor-Suppressing Impact of Myoglobin on a Subset of Human Breast Cancer Cells Open
The expression of myoglobin (MB), well known as the oxygen storage and transport protein of myocytes, is a novel hallmark of the luminal subtype in breast cancer patients and correlates with better prognosis. The mechanisms by which MB imp…
View article: The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism
The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism Open
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia, and progressive organ failure. Chronic inflammatory state …