Michael A. Gordon
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View article: A 10-Year Review of the Efficacy of Cranial Remolding Orthosis Treatment and Factors That Influence Outcomes for Infants with Isolated Deformational Plagiocephaly
A 10-Year Review of the Efficacy of Cranial Remolding Orthosis Treatment and Factors That Influence Outcomes for Infants with Isolated Deformational Plagiocephaly Open
Background/objectives: The purpose of this study was to examine the overall efficacy and treatment outcomes of CROs in the treatment of isolated deformational plagiocephaly and investigate the variables that influence treatment efficacy. M…
View article: A phase 4, multicenter, global clinical study to evaluate discontinuation and rechallenge of pexidartinib in patients with tenosynovial giant cell tumor previously treated with pexidartinib
A phase 4, multicenter, global clinical study to evaluate discontinuation and rechallenge of pexidartinib in patients with tenosynovial giant cell tumor previously treated with pexidartinib Open
Background Pexidartinib is effective in patients with tenosynovial giant cell tumor (TGCT) for whom surgery is not feasible. Durability of response after discontinuation of pexidartinib and the safety and efficacy of restarting pexidartini…
View article: Data from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Data from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Tryptophan-2,3-dioxygenase (TDO2), a rate-limiting enzyme in the tryptophan catabolism pathway, is induced in triple-negative breast cancer (TNBC) by inflammatory signals and anchorage-independent conditions. TNBCs express extremely low le…
View article: Supplementary Figure 1 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Supplementary Figure 1 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Comparison of Gene Signatures following miR-200c Restoration in TNBC Cells.
View article: Supplementary Figure 1 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Supplementary Figure 1 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Comparison of Gene Signatures following miR-200c Restoration in TNBC Cells.
View article: Supplementary Figure 2 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Supplementary Figure 2 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Expanded GSEA results following miR-200c restoration in TNBC cells.
View article: Supplementary Table 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 41K, QPCR validation.
View article: Supplementary Figure 3 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Supplementary Figure 3 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Effects of TNF-a or IL-1B or the combination on HO-1 protein in BT549 cells.
View article: Supplementary Figure S3 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Supplementary Figure S3 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer Open
RPPA heatmap all significant proteins by ANOVA
View article: Supplementary Methods from Cooperative Dynamics of AR and ER Activity in Breast Cancer
Supplementary Methods from Cooperative Dynamics of AR and ER Activity in Breast Cancer Open
Supplementary Methods
View article: Supplementary Table S2 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Supplementary Table S2 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer Open
RPPA all significant proteins
View article: Data from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Data from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer Open
The androgen receptor (AR) is widely expressed in breast cancer, and evidence suggests dependence on AR signaling for growth and survival. AR antagonists such as enzalutamide and seviteronel have shown success in preclinical models and cli…
View article: Supplementary Figure 2 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Supplementary Figure 2 from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Expanded GSEA results following miR-200c restoration in TNBC cells.
View article: Supplementary Figure S1 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Supplementary Figure S1 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer Open
In vivo randomization/matching data
View article: Supplementary Methods from Cooperative Dynamics of AR and ER Activity in Breast Cancer
Supplementary Methods from Cooperative Dynamics of AR and ER Activity in Breast Cancer Open
Supplementary Methods
View article: Supplementary Figure S2 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Supplementary Figure S2 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer Open
SKBR3 western blot
View article: Supplementary Table 4 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 4 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 62K, unsupervised top 10 positive and negative correlated genes - 5-FU inducible.
View article: Supplementary Table 5 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 5 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 63K, unsupervised top 10 positive and negative correlated genes - SN38 basal.
View article: Supplementary Figure 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Figure 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 32K, QPCR validations.
View article: Supplementary Table 3 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 3 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 61K, unsupervised top 10 positive and negative correlated genes - 5-FU basal.
View article: Data from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Data from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
Chemotherapy response rates for advanced colorectal cancer remain disappointingly low, primarily because of drug resistance, so there is an urgent need to improve current treatment strategies. To identify novel determinants of resistance t…
View article: Supplementary Figure Legends from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Supplementary Figure Legends from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer Open
Figure legends for supplementary data
View article: Supplementary Figure S1 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Supplementary Figure S1 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer Open
In vivo randomization/matching data
View article: Data from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Data from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Tryptophan-2,3-dioxygenase (TDO2), a rate-limiting enzyme in the tryptophan catabolism pathway, is induced in triple-negative breast cancer (TNBC) by inflammatory signals and anchorage-independent conditions. TNBCs express extremely low le…
View article: Table S1. Immunosuppressive Pathways Decreased Following miR-200c Restoration from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Table S1. Immunosuppressive Pathways Decreased Following miR-200c Restoration from Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression Open
Extended list of genes associated with enriched immunosuppressive pathways following GSEA analysis in BT549-TripZ-200c cells following miR-200c restoration.
View article: Data from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Data from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer Open
Preclinical and early clinical trials indicate that up to 50% of triple-negative breast cancers (TNBC) express androgen receptor (AR) and are potentially responsive to antiandrogens. However, the function of AR in TNBC and the mechanisms b…
View article: Supplemental Figure 1 from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Supplemental Figure 1 from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer Open
Immunohistochemistry for AR in BT549 cells cultured in attached or forced suspension culture conditions.
View article: Supplemental Figure 2 from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Supplemental Figure 2 from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer Open
Limiting dilution tumor size.
View article: Supplemental Figure 1 from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Supplemental Figure 1 from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer Open
Immunohistochemistry for AR in BT549 cells cultured in attached or forced suspension culture conditions.
View article: A Comprehensive Enhanced Recovery Pathway for Rotator Cuff Surgery Reduces Pain, Opioid Use, and Side Effects
A Comprehensive Enhanced Recovery Pathway for Rotator Cuff Surgery Reduces Pain, Opioid Use, and Side Effects Open
Background Patients often have moderate to severe pain after rotator cuff surgery, despite receiving analgesics and nerve blocks. There are many suggested ways to improve pain after rotator cuff surgery, but the effects of adopting a pathw…