Max Harner
YOU?
Author Swipe
View article: The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane
The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane Open
Mitochondrial architecture and the contacts between the mitochondrial outer and the inner membranes depend on the mitochondrial contact site and cristae-organizing system (MICOS) that is highly conserved from yeast to human. Variants in th…
View article: The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane
The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane Open
Mitochondrial architecture and the contacts between the outer and the inner mitochondrial membrane depend on the mitochondrial contact site and cristae organizing system (MICOS) that is highly conserved from yeast to human. Mutations in th…
View article: The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria
The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria Open
Mitochondria are essential organelles of eukaryotic cells and are characterized by their unique and complex membrane system. They are confined from the cytosol by an envelope consisting of two membranes. Signals, metabolites, proteins and …
View article: Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells
Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells Open
In the ovary, proliferation and differentiation of granulosa cells (GCs) drive follicular growth. Our immunohistochemical study in a non-human primate, the Rhesus monkey, showed that the mitochondrial activity marker protein cytochrome c o…
View article: The dsRBP Staufen2 governs RNP assembly of neuronal Argonaute proteins
The dsRBP Staufen2 governs RNP assembly of neuronal Argonaute proteins Open
Mature microRNAs are bound by a member of the Argonaute (Ago1-4) protein family, forming the core of the RNA-induced silencing complex (RISC). Association of RISC with target mRNAs results in ribonucleoprotein (RNP) assembly involved in tr…
View article: RNA supply drives physiological granule assembly in neurons
RNA supply drives physiological granule assembly in neurons Open
Membraneless cytoplasmic condensates of mRNAs and proteins, known as RNA granules, play pivotal roles in the regulation of mRNA fate. Their maintenance fine-tunes time and location of protein expression, affecting many cellular processes, …
View article: The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria
The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria Open
Mitochondria are essential organelles of eukaryotic cells that are characterized by their unique and complex membrane system. They are confined from the cytosol by an envelope consisting of two membranes. Signals, metabolites, proteins and…
View article: RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons
RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons Open
RNA-binding proteins (RBPs) act as posttranscriptional regulators controlling the fate of target mRNAs. Unraveling how RNAs are recognized by RBPs and in turn are assembled into neuronal RNA granules is therefore key to understanding the u…
View article: Pumilio2 Promotes Growth of Mature Neurons
Pumilio2 Promotes Growth of Mature Neurons Open
RNA-binding proteins (RBPs) are essential regulators controlling both the cellular transcriptome and translatome. These processes enable cellular plasticity, an important prerequisite for growth. Cellular growth is a complex, tightly contr…
View article: Pumilio2 and Staufen2 selectively balance the synaptic proteome
Pumilio2 and Staufen2 selectively balance the synaptic proteome Open
Neurons have the capacity to adapt to environmental stimuli, a phenomenon termed cellular plasticity. The underlying processes are controlled by a network of RNA-binding proteins (RBPs). Their precise impact, however, is largely unknown. T…
View article: HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE
HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE Open
Yeast vacuole fusion requires R-SNARE, Q-SNAREs, and HOPS. A HOPS SM-family subunit binds the R- and Qa-SNAREs. We now report that HOPS binds each of the four SNAREs. HOPS catalyzes fusion when the Q-SNAREs are not pre-assembled, ushering …
View article: HOPS recognizes each SNARE, assembling ternary <i>trans</i>-complexes for sudden fusion upon engagement with the 4th SNARE
HOPS recognizes each SNARE, assembling ternary <i>trans</i>-complexes for sudden fusion upon engagement with the 4th SNARE Open
Vacuole fusion requires SNAREs, Sec17/18, a Rab, and HOPS. We find that co-incubation of HOPS, proteoliposomes bearing the Rab and R-SNARE, and proteoliposomes with the Rab and any two Q-SNAREs yields a trans complex which includes these 3…
View article: An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation
An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation Open
Metabolic function and architecture of mitochondria are intimately linked. More than 60 years ago, cristae were discovered as characteristic elements of mitochondria that harbor the protein complexes of oxidative phosphorylation, but how c…
View article: Author response: An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation
Author response: An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Materials and methods References Decision letter Author response Article and author information Metrics Abstract Metabolic function and architecture of mito…