Explanipedia

Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice Open

Van Duc Dang, Franziska Szelinski, Elodie Mohr, Tuan Anh Le, Jacob Ritter , et al. · 2025

Plasma cells (PC) participate in the pathogenesis of systemic lupus erythematosus (SLE) through sustained autoantibody and inflammatory cytokine secretion. Current PC-depleting therapies risk eliminating protective long-lived PCs, highligh…

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection Open

Valerie Plajer, Adrián Madrigal-Avilés, Maria Dzamukova, Nayar Durán-Hernández, Philippe Saikali , et al. · 2025

Virus-specific CD4 + T cells typically undergo T helper (Th) 1 differentiation and contribute to a type 1 immune response in infection with lymphocytic choriomeningitis virus (LCMV). Using this model pathogen, we performed an in-depth anal…

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis Open

Roodline Cineus, Yanjiang Luo, Mariia Saliutina, Subhakankha Manna, C Cancino , et al. · 2025

Multicellular cytokine networks drive intestinal inflammation and colitis-associated cancer (CAC). Interleukin-22 (IL-22) exerts both protective and pathogenic effects in the intestine, but the mechanisms that regulate this balance remain …

The impact of disease and species differences on the intestinal CLCA4 gene expression Open

K Teske, Nancy A. Erickson, Amelia Huck, Maria Dzamukova, Marcus Fulde , et al. · 2025

The human chloride channel regulator, calcium-activated (CLCA) 4 is discussed as a driver of epithelial-to-mesenchymal transition as well as a biomarker for colorectal cancer (CRC) and ulcerative colitis. In contrast to humans, the Clca4 g…

D-Lactate drives cytotoxicity in Th1 cells by limiting mitochondrial ROS production through enhanced glyoxalase system activity Open

Adrian Madrigal-Avilés, Valerie Plajer, Sebastian Serve, Maria Dzamukova, Leticia Soriano‐Baguet , et al. · 2025

L-lactate, long considered a byproduct of the glycolytic shift in activated CD4 + T cells, has been shown to impact T-cell differentiation and cytokine production. However, D-lactate’s role in immunity remains poorly understood. Here we co…

The interleukin 22–oncostatin M axis promotes intestinal inflammation and tumorigenesis Open

Ahmed N. Hegazy, Roodline Cineus, Yanjiang Luo, Mariia Saliutina, D Boesel , et al. · 2024

Multicellular cytokine networks orchestrate the onset and progression of intestinal inflammation and colitis-associated cancer (CAC). Interleukin 22 (IL-22), a member of the IL-10 superfamily, is known for its ability to promote epithelial…

Plasticity and lineage commitment of individual T<sub>H</sub>1 cells are determined by stable T-bet expression quantities Open

Ahmed N. Hegazy, Caroline Peine, Dominik Niesen, Isabel Panse, Yevhen Vainshtein , et al. · 2024

T helper 1 (T H 1) cell identity is defined by the expression of the lineage-specifying transcription factor T-bet. Here, we examine the influence of T-bet expression heterogeneity on subset plasticity by leveraging cell sorting of distinc…

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota Open

Ivo Röwekamp, Laura Maschirow, Anne Rabes, Facundo Fiocca Vernengo, Lutz Hamann , et al. · 2024

IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus…

A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses Open

Tobias M. Brunner, Sebastian Serve, Anna‐Friederike Marx, Jelizaveta Fadejeva, Philippe Saikali , et al. · 2024

GATA-3 Localization Shapes Lymphocyte Function Open

Philippe Saikali, Maria Dzamukova, Christina Stehle, Trung Viet Nguyen, Tobias M. Brunner , et al. · 2024

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota Open

Ivo Röwekamp, Laura Maschirow, Anne Rabes, Facundo Fiocca Vernengo, Gitta Anne Heinz , et al. · 2023

IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus…

NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis Open

Ping Shen, Sebastian Serve, Peihua Wu, Xiaohui Liu, Yujie Dai , et al. · 2023

Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain. Although age and joint trauma are prominently associated with OA occurrence, the trigger and signaling pathways propagating their pathogenic aspects are…

A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models Open

Angelique Wolter, Christian H. Bucher, Sebastian Kurmies, Viktoria Schreiner, Frank Konietschke , et al. · 2023

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection Open

Anna‐Friederike Marx, Sandra M. Kallert, Tobias M. Brunner, José A. Villegas, Florian Geier , et al. · 2023

Raw data underlying the publication

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection Open

Anna‐Friederike Marx, Sandra M. Kallert, Tobias M. Brunner, José A. Villegas, Florian Geier , et al. · 2023

T cell factor 1 (Tcf-1) expressing CD8⁺ T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection and cancer. Yet, the signals that promote the formation and maintena…

A type-1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T cell responses Open

Max Löhning, Tobias M. Brunner, Sebastian Serve, Anna‐Friederike Marx, Maria Dzamukova , et al. · 2023

The pleiotropic alarmin interleukin-33 (IL-33) drives type-1, type-2, and regulatory T-cell responses via its receptor ST2. Subset-specific differences in ST2 expression intensity and dynamics suggest that transcriptional regulation is key…

Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone Open

Ping Shen, Max Löhning · 2022

Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome Open

Ping Shen, Peihua Wu, Tazio Maleitzke, Marie–Jacqueline Reisener, Gitta Anne Heinz , et al. · 2022

The isolation of chondrocytes from human articular cartilage for single-cell RNA sequencing requires extensive and prolonged tissue digestion at 37 C. Modulations of the transcriptional activity likely take place during this period such th…

Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells Open

Philipp Burt, Caroline Peine, Caroline Peine, Z Borek, Sebastian Serve , et al. · 2022

Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th-cell lineages, hybrid …

Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities Open

Ahmed N. Hegazy, Caroline Peine, Dominik Niesen, Isabel Panse, Yevhen Vainshtein , et al. · 2022

SUMMARY T helper 1 (Th1) cell identity is defined by the expression of the lineage-defining transcription factor T-bet. Here, we examine the influence of T-bet expression heterogeneity on subset plasticity by leveraging cell sorting of dis…

A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models Open

Angelique Wolter, Christian H. Bucher, Sebastian Kurmies, Viktoria Schreiner, Frank Konietschke , et al. · 2022

Adequate pain management is essential for ethical and scientific reasons in animal experiments and should completely cover the period of expected pain without the need for frequent re-application. However, current depot formulations of Bup…

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth Open

Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla‐Zarebska, Frederik Heinrich, Laura Brylka , et al. · 2022

Bone growth requires a specialised, highly angiogenic blood vessel subtype, so-called type H vessels, which pave the way for osteoblasts surrounding these vessels. At the end of adolescence, type H vessels differentiate into quiescent type…

High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells Open

Philipp Burt, Caroline Peine, Caroline Peine, Z Borek, Sebastian Serve , et al. · 2022

Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th cell lineages, hybrid …

Menstrual blood-derived mesenchymal stromal cells efficiently ameliorate experimental autoimmune encephalomyelitis by inhibiting T cell activation in mice Open

Yonghai Li, Haiyao Gao, Tobias M. Brunner, Xiaoxi Hu, Yushan Yan , et al. · 2022

CD39 and CD326 Are Bona Fide Markers of Murine and Human Plasma Cells and Identify a Bone Marrow Specific Plasma Cell Subpopulation in Lupus Open

Van Duc Dang, Elodie Mohr, Franziska Szelinski, Tuan Anh Le, Jacob Ritter , et al. · 2022

Antibody-secreting cells (ASCs) contribute to immunity through production of antibodies and cytokines. Identification of specific markers of ASC would allow selective targeting of these cells in several disease contexts. Here, we performed…

Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection Open

Kerstin Narr, Yusuf I. Ertuna, Bénédict Fallet, Karen Cornille, Mirela Dimitrova , et al. · 2021

Significance Vaccines against persisting viruses such as HIV or hepatitis C virus remain a significant unmet global need. Long-lived memory B cells can be induced by vaccination to form an important pillar of antiviral immunity, yet persis…

Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection" Open

Kerstin Narr, Yusuf I. Ertuna, Bénédict Fallet, Karen Cornille, Mirela Dimitrova , et al. · 2021

Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".

Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection" Open

Kerstin Narr, Yusuf I. Ertuna, Bénédict Fallet, Karen Cornille, Mirela Dimitrova , et al. · 2021

Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".

Mast Cells Modulate Antigen-Specific CD8+ T Cell Activation During LCMV Infection Open

Yana Hackler, Frank Siebenhaar, Max Löhning, Marcus Maurer, Melba Muñoz · 2021

Mast cells (MCs), strategically localized at mucosal surfaces, provide first-line defense against pathogens and shape innate and adaptive immune responses. Recent studies have shown that MCs are involved in pathogenic responses to several …

Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10 Open

Melba Muñoz, Ahmed N. Hegazy, Tobias M. Brunner, Vivien Holecska, Roman Marek , et al. · 2021

Significance Strategies to suppress memory T cell responses are needed. Th2-polarized cells lacking the transcription factor T-bet strongly suppress not only naive but also memory T cell responses via IL-10 and protect mice against the dev…

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