Max Tamlander
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View article: A-231 A novel assay measuring leukocyte lipid uptake and storage for treatment optimization in dyslipidemia and cardiovascular risk assessment
A-231 A novel assay measuring leukocyte lipid uptake and storage for treatment optimization in dyslipidemia and cardiovascular risk assessment Open
Background Elevated blood cholesterol, especially in the form of low-density lipoprotein cholesterol (LDL-C) is causing atherosclerotic cardiovascular c disease, one of the most common causes of death worldwide. Despite the availability of…
View article: The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases
The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases Open
Both socioeconomic circumstances and genetic predisposition shape disease risk, yet their joint contribution across diseases has not been systematically examined. We studied 19 high-burden diseases in 743,194 participants (729,928 European…
View article: Linking Variability of Leukocyte Lipid Metabolism to Circulating Lipids, Lipoprotein Composition, and Cardiovascular Risk in the Finnish Adult Population
Linking Variability of Leukocyte Lipid Metabolism to Circulating Lipids, Lipoprotein Composition, and Cardiovascular Risk in the Finnish Adult Population Open
BACKGROUND: Interindividual differences in outcomes of lipid-lowering therapy are well known. Here, we aimed to characterize how alterations in cellular lipid uptake, storage, and utilization pathways may contribute to different treatment …
View article: Missense variants in FRS3 affect body mass index in populations of diverse ancestries
Missense variants in FRS3 affect body mass index in populations of diverse ancestries Open
View article: Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease
Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease Open
Limited access to functional information of genetic variants reduces the applicability of genetic tools for precision medicine applications in cardiovascular disease. We established an automated analysis platform based on multiplexed high-…
View article: Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women
Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women Open
PURPOSE Family history (FH) and pathogenic variants (PVs) are used for guiding risk surveillance in selected high-risk women but little is known about their impact for breast cancer screening on population level. In addition, polygenic ris…
View article: High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases
High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases Open
Formalin-fixed paraffin-embedded (FFPE) tissues stored in biobanks and pathology archives are a vast but underutilized source for molecular studies on different diseases. Beyond being the "gold standard" for preservation of diagnostic huma…
View article: Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening Open
Background Hereditary factors, including single genetic variants and family history, can be used for targeting colorectal cancer (CRC) screening, but limited data exist on the impact of polygenic risk scores (PRS) on risk-based CRC screeni…
View article: Large-scale functional characterization of low-density lipoprotein receptor gene variants improves risk assessment in cardiovascular disease
Large-scale functional characterization of low-density lipoprotein receptor gene variants improves risk assessment in cardiovascular disease Open
Aims Lack of functional information for low-density lipoprotein (LDL) receptor (LDLR) mutations limits the use of genetics for early diagnosis, risk assessment and clinical decision making in familial hypercholesterolemia (FH). The goal of…
View article: Linking cellular lipid trafficking profiles of individuals to the outcomes of cholesterol-lowering therapy in the general population
Linking cellular lipid trafficking profiles of individuals to the outcomes of cholesterol-lowering therapy in the general population Open
View article: Functional analysis of LDLR variants using automated systems to improve rare-variant association studies and risk assessment in hypercholesterolemia
Functional analysis of LDLR variants using automated systems to improve rare-variant association studies and risk assessment in hypercholesterolemia Open
View article: Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5
Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5 Open
Our study is the largest genome-wide association study to date on SI-NETs and reported 4 new associated genome-wide association study loci, including a novel missense mutation (rs200138614, p.Cys712Phe) in LGR5, a canonical marker of adult…
View article: Linking biological variation to outcomes of statin treatment in the general population
Linking biological variation to outcomes of statin treatment in the general population Open
Interindividual differences for outcomes of lipid-lowering therapy are well known. Alterations in cellular pathways may contribute to the phenomenon. To address this question, we employed an automated multiplexed analysis pipeline to syste…
View article: Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation
Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation Open
View article: Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes Open