Mark T. Smith
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View article: Genomics of Acute Myeloid Leukemia at Diagnosis and Remission
Genomics of Acute Myeloid Leukemia at Diagnosis and Remission Open
Accurate and comprehensive genetic characterization of acute myeloid leukemia (AML) is essential for diagnosis, prognostication, and treatment selection. We report here, in 255 adults with AML enrolled in a prospective clinical protocol at…
View article: The MEASURE Genome Atlas: Acute Myeloid Leukemia at diagnosis and complete remission
The MEASURE Genome Atlas: Acute Myeloid Leukemia at diagnosis and complete remission Open
Introduction: Genetic profiling is essential for optimal management of patients with acute myeloid leukemia (AML). Whole genome sequencing (WGS) has been proposed as a replacement for the multiple testing modalities currently in use but ha…
View article: StageACT: Stage-Conditioned Imitation for Robust Humanoid Door Opening
StageACT: Stage-Conditioned Imitation for Robust Humanoid Door Opening Open
Humanoid robots promise to operate in everyday human environments without requiring modifications to the surroundings. Among the many skills needed, opening doors is essential, as doors are the most common gateways in built spaces and ofte…
View article: Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Open
Significance Statement Patients with CKD who are on hemodialysis are hyporesponsive to erythropoiesis-stimulating agents (ESAs) because of anemia of inflammation mediated by IL-6–induced expression of hepcidin, an iron regulatory hormone. …
View article: Optimizing the Use of Phase Change Material Vests Worn During Explosives Ordnance Disposal Operations in Hot Conditions
Optimizing the Use of Phase Change Material Vests Worn During Explosives Ordnance Disposal Operations in Hot Conditions Open
Phase change material (PCM) cooling garments' efficacy is limited by the duration of cooling provided. The purpose of this study was to evaluate the effect of replacing a PCM vest during a rest period on physiological and perceptual respon…
View article: Pd21: An Education Consortium For Product Development Leadership
Pd21: An Education Consortium For Product Development Leadership Open
NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract Main Menu Session 2342 PD21: An Education Consortium for Product Development Leadership Mark Smith, Denny Mahoney, Wally Owen, Hriday P…
View article: Technology in University Physical Activity Courses: A Mini-Ethnographic Case Study
Technology in University Physical Activity Courses: A Mini-Ethnographic Case Study Open
As younger generations become increasingly reliant on technology, higher educational institutions must continually attempt to stay with or ahead of the curve to foster 21st century teaching and learning. College and university physical act…
View article: Long-term Safety of Epoetin Alfa-epbx for the Treatment of Anemia in ESKD: Pooled Analyses of Randomized and Open-label Studies
Long-term Safety of Epoetin Alfa-epbx for the Treatment of Anemia in ESKD: Pooled Analyses of Randomized and Open-label Studies Open
Rationale & Objective
\nEpoetin alfa-epbx is a biosimilar to the reference product, epoetin alfa. We compare the safety of epoetin alfa-epbx versus epoetin alfa based on a pooled analysis of findings from 2 randomized, double-blind, compar…
View article: Drought Impacts and Compounding Mortality on Forest Trees in the Southern Sierra Nevada
Drought Impacts and Compounding Mortality on Forest Trees in the Southern Sierra Nevada Open
The increase in compounding disturbances, such as “hotter droughts” coupled with insect outbreaks, has significant impacts on the integrity of forested ecosystems and their subsequent management for important ecosystem services and multipl…
View article: Polyvinylsulfonic acid: A Low-cost RNase inhibitor for enhanced RNA preservation and cell-free protein translation
Polyvinylsulfonic acid: A Low-cost RNase inhibitor for enhanced RNA preservation and cell-free protein translation Open
The effectiveness and economics of polyvinyl sulfonic acid (PVSA) as a ribonuclease inhibitor for in vitro systems is reported. PVSA was shown to inhibit RNA cleavage in the presence of RNase A as well as in the presence of Escherichia col…
View article: PowerPoint Slides for: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease
PowerPoint Slides for: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease Open
Background: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being inv…
View article: Cancer therapeutic Onconase and lyophilized cell-free protein expression systems
Cancer therapeutic Onconase and lyophilized cell-free protein expression systems Open
Recently reported high-yield synthesis of cytotoxic protein Onconase from lyophilized E. coli extract preparations demonstrates the utility of lyophilized cell-free protein expression and its potential for creating on-demand biotherapeutic…
View article: Supplementary Material for: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease
Supplementary Material for: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease Open
Background: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being inv…
View article: PowerPoint Slides for: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease
PowerPoint Slides for: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease Open
Background: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being inv…
View article: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease
Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease Open
Background: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being inv…
View article: Manufacturing Experience for Oxide Dispersion Strengthened Alloys
Manufacturing Experience for Oxide Dispersion Strengthened Alloys Open
This report documents the results of the development and the manufacturing experience gained at the Pacific Northwest National Laboratories (PNNL) while working with the oxide dispersion strengthened (ODS) materials MA 956, 14YWT, and 9YWT…
View article: FY16 Status Report for the Uranium-Molybdenum Fuel Concept
FY16 Status Report for the Uranium-Molybdenum Fuel Concept Open
The Fuel Cycle Research and Development program of the Office of Nuclear Energy has implemented a program to develop a Uranium-Molybdenum metal fuel for light water reactors. Uranium-Molybdenum fuel has the potential to provide superior pe…
View article: Augmented and Mixed Reality Features and Tools for Remote Laboratory Experiments
Augmented and Mixed Reality Features and Tools for Remote Laboratory Experiments Open
Augmented Reality (AR) is the process of overlaying meaningful interactive information in a live video stream for creating an enriched visual experience for users. Within Remote Access Laboratories (RAL) this enables users to gain design e…