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View article: Does the audiogram shape influence the intracochlear recording of Electrocochleography during and after cochlear implantation?
Does the audiogram shape influence the intracochlear recording of Electrocochleography during and after cochlear implantation? Open
During cochlear implant (CI) surgery, it is desirable to perform intraoperative measurements such as Electrocochleography (ECochG) to monitor the inner ear function and thereby to support the preservation of residual hearing. However, a si…
View article: How reliable is artificial intelligence in the diagnosis of cholesteatoma on CT images?
How reliable is artificial intelligence in the diagnosis of cholesteatoma on CT images? Open
AI is making rapid progress in imaging, with recent studies already showing remarkable performance in cholesteatoma diagnosis. The speed of technological development is promising. However, to ensure safe and effective implementation in cli…
View article: Cochlear coverage with lateral wall cochlear implant electrode arrays affects post-operative speech recognition
Cochlear coverage with lateral wall cochlear implant electrode arrays affects post-operative speech recognition Open
Objectives The goal was to investigate the relationship between the insertion angle/cochlear coverage of cochlear implant electrode arrays and post-operative speech recognition scores in a large cohort of patients implanted with lateral wa…
View article: Virtual cochlear implantation for personalized rehabilitation of profound hearing loss
Virtual cochlear implantation for personalized rehabilitation of profound hearing loss Open
In cochlear implantation, current preoperative planning procedures allow for estimating how far a specific implant will reach into the inner ear of the patient, which is important to optimize hearing preservation and speech perception outc…
View article: Cochlear Implantation in Obliterated Cochlea: A Retrospective Analysis and Comparison between the IES Stiff Custom-Made Device and the Split-Array and Regular Electrodes
Cochlear Implantation in Obliterated Cochlea: A Retrospective Analysis and Comparison between the IES Stiff Custom-Made Device and the Split-Array and Regular Electrodes Open
Anatomical malformations, obliterations of the cochlea, or re-implantations pose particular challenges in cochlear implantation. Treatment methods rely on radiological and intraoperative findings and include incomplete insertion, the impla…
View article: Ex Vivo Evaluation of a Minimally Invasive Approach for Cochlear Implant Surgery
Ex Vivo Evaluation of a Minimally Invasive Approach for Cochlear Implant Surgery Open
First evaluation of the new system in a comprehensive ex vivo study demonstrating sufficient accuracy and the feasibility of the whole concept.
View article: Clinical test results on patients with a novel electrical hearing prosthesis: the two-shank Auditory Midbrain Implant (AMI)
Clinical test results on patients with a novel electrical hearing prosthesis: the two-shank Auditory Midbrain Implant (AMI) Open
During 2017 to 2019, five deaf patients with neurofibromatosis type II (NF2) were implanted at Hannover Medical School with a novel central auditory prosthesis – the Auditory Midbrain Implant (AMI). The AMI was developed as an alternative …
View article: Optimized cochlear coverage to improve cochlear implant outcome
Optimized cochlear coverage to improve cochlear implant outcome Open
Introduction Despite the general success of treatment with cochlear implants (CIs) there is still a high variability in individual hearing success. Among other things hearing success can be affected by the position of the electrode array i…
View article: The RobOtol system in clinical applications – our first clinical experience with the robot-assisted insertion of CI electrodes with simultaneous cochlear monitoring
The RobOtol system in clinical applications – our first clinical experience with the robot-assisted insertion of CI electrodes with simultaneous cochlear monitoring Open
The RobOtol system (from Collin) is the first commercially available robot for the assisted insertion of CI electrodes. Initial clinical studies have shown that robot-assisted electrode insertion can reduce surgical trauma. We report on o…
View article: MyCI – an app for individualized cochlear implantation
MyCI – an app for individualized cochlear implantation Open
Cochlear implants provide effective auditory rehabilitation for many deaf or profound hearing loss patients. Many aspects such as duration of deafness, respective hearing loss, individual anatomy must be considered preoperatively in order …
View article: Development and translation of a novel electrical hearing prosthesis for direct stimulation within the auditory nerve: the Auditory Nerve Implant (ANI)
Development and translation of a novel electrical hearing prosthesis for direct stimulation within the auditory nerve: the Auditory Nerve Implant (ANI) Open
In collaboration with several institutions, an intracranial electrical hearing prosthesis is currently being developed, which stimulates directly in the auditory nerve between the cochlea and the brainstem: the Auditory Nerve Implant (ANI)…
View article: Cochlear monitoring during and after CI-Insertion using intracochlearly recorded Electrocochleography
Cochlear monitoring during and after CI-Insertion using intracochlearly recorded Electrocochleography Open
Introduction To preserve residual hearing during CI insertion it is desirable to use intraoperative monitoring of the cochlea. A promising approach is the recording of cochlear microphonics using Electrocochleography (ECochG).
View article: Determination of contact-specific insertion angles using planning software for cochlear implantation.
Determination of contact-specific insertion angles using planning software for cochlear implantation. Open
Objective Tthe cochlea structure can vary between subjects. In order to take this great anatomical variability into account, the anatomy of a specific cochlea can be identified with the help of clinical digital volume tomography (DVT) and …
View article: First clinical experience with the Fibrotic Obliteration Probe - a new instrument to support CI implantation in fibrosis of the cochlea
First clinical experience with the Fibrotic Obliteration Probe - a new instrument to support CI implantation in fibrosis of the cochlea Open
Introduction Anatomical malformations, obliterations of the cochlea or reimplantations pose particular challenges in CI care. Treatment methods include incomplete insertion, implantation of a double array and radical cochleostomy. MED-EL h…
View article: Influence of cochlear covering on speech understanding with FLEX electrodes in patients with electrode migration
Influence of cochlear covering on speech understanding with FLEX electrodes in patients with electrode migration Open
Introduction Cochlear implants are an established therapy for deaf patients or patients with a profound hearing loss for whom hearing aid is no longer adequate. The cochlear coverage seems to be a factor in the later understanding of speec…
View article: Additional file 14 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 14 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 14. Master regulator molecules of genes downregulated in GE2-hepatocellular carcinoma (HCC). Significantly down regulated genes in GE2-HCC (n=13) versus NT (n=17) samples with mean fold change (FC) ≤ -2 and false discovery …
View article: Additional file 11 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 11 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 11. Master regulator molecules of genes upregulated in GE1-hepatocellular carcinoma (HCC). Significantly up regulated genes in GE1-HCC (n=10) versus NT (n=17) samples with mean fold change (FC) ≥ 2 and P ≤ 0.01 were identif…
View article: Additional file 2 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 2 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 2. Differentially expressed probe sets in hepatocellular carcinoma (HCC) versus non-tumourous (NT) tissues. Unpaired Welch’s t-test was performed using gene expression microarray data from 23 HCC and 17 NT samples. The prob…
View article: Additional file 5 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 5 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 5. List of differentially expressed probe sets in 13 GE2-hepatocellular carcinoma (HCC) versus 17 non-tumourous (NT) tissues. Unpaired Welch’s t-test was performed using gene expression microarray data from GE2-HCC (n=13) a…
View article: Additional file 4 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 4 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 4. List of differentially expressed probe sets in GE1-hepatocellular carcinoma (HCC) versus non-tumourous (NT) tissues. Unpaired Welch’s t-test was performed using gene expression microarray data from GE1-HCC (n=10) and NT …
View article: Additional file 12 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 12 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 12. Master regulator molecules of genes upregulated in GE2-hepatocellular carcinoma (HCC). Significantly up regulated genes in GE2-HCC (n=13) versus NT (n=17) samples with mean fold change (FC) ≥ 2 and false discovery rate …
View article: Additional file 18 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 18 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 18. Lists of overrepresented transcription factor binding sites (TFBSs) in genes downregulated in GE2-hepatocellular carcinoma (HCC). Significantly down regulated genes in GE2-HCC (n=13) versus NT (n=17) samples with mean f…
View article: Additional file 16 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 16 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 16. Lists of overrepresented transcription factor binding sites (TFBSs) in genes upregulated in GE2-hepatocellular carcinoma (HCC). Significantly up regulated genes in GE2-HCC (n=13) versus NT (n=17) samples with mean fold …
View article: Additional file 6 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 6 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 6. List of differentially expressed probe sets in 13 GE2-hepatocellular carcinoma (HCC) versus 10 GE1-HCC samples. Unpaired Welch’s t-test was performed using gene expression microarray data from GE2-HCC (n=13) and GE1-HCC …
View article: Additional file 1 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 1 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 1. Clinicopathological data of the patients with liver carcinoma used in the study.
View article: Additional file 15 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 15 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 15. Lists of overrepresented transcription factor binding sites (TFBSs) in genes upregulated in GE1-hepatocellular carcinoma (HCC). Significantly upregulated genes in GE1-HCC (n=10) versus NT (n=17) samples with mean fold c…
View article: Additional file 17 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 17 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 17. Lists of overrepresented transcription factor binding sites (TFBSs) in genes downregulated in GE1-hepatocellular carcinoma (HCC). Significantly down regulated genes in GE1-HCC (n=10) versus NT (n=17) samples with mean f…
View article: Additional file 13 of Gene networks and transcriptional regulators associated with liver cancer development and progression
Additional file 13 of Gene networks and transcriptional regulators associated with liver cancer development and progression Open
Additional file 13. Master regulator molecules of genes downregulated in GE1-hepatocellular carcinoma (HCC). Significantly down regulated genes in GE1-HCC (n=10) versus NT (n=17) samples with mean fold change (FC) ≤ -2 and P ≤ 0.01 were id…
View article: First results of electrode reimplantation and its hypothetical dependence from artificial brain maturation
First results of electrode reimplantation and its hypothetical dependence from artificial brain maturation Open
Background After introducing the first Cochlear Implants also in children theses are grown with electrical intracochlear stimulation and subsequent auditory cortical development. Over the meantime the positioning of the electrode was chang…