Max Vikström
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View article: CYP2D6-inhibiting drugs and risk of fall injury after newly initiated therapy with beta-blockers—a register-based case-crossover study
CYP2D6-inhibiting drugs and risk of fall injury after newly initiated therapy with beta-blockers—a register-based case-crossover study Open
We assessed whether concomitant use of CYP2D6-inhibiting drugs associates with increased risk of fall injuries after newly initiated therapy with beta-blockers. A case-crossover study design was applied which eliminates confounding from in…
View article: Metal ratios as possible biomarkers for amyotrophic lateral sclerosis
Metal ratios as possible biomarkers for amyotrophic lateral sclerosis Open
Metal ratios may be used as biomarkers in ALS diagnosis and as guidelines for preventive measures.
View article: Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis Open
Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator–activated receptor gamm…
View article: Antibodies Against Phosphorylcholine Among 60-Year-Olds: Clinical Role and Simulated Interactions
Antibodies Against Phosphorylcholine Among 60-Year-Olds: Clinical Role and Simulated Interactions Open
Aims Antibodies against phosphorylcholine (anti-PC) are implicated as protection markers in atherosclerosis, cardiovascular disease (CVD), and other chronic inflammatory conditions. Mostly, these studies have been focused on IgM. In this s…
View article: A Swedish primary healthcare prevention programme focusing on promotion of physical activity and a healthy lifestyle reduced cardiovascular events and mortality: 22-year follow-up of 5761 study participants and a reference group
A Swedish primary healthcare prevention programme focusing on promotion of physical activity and a healthy lifestyle reduced cardiovascular events and mortality: 22-year follow-up of 5761 study participants and a reference group Open
Objective To evaluate long-term risk of first cardiovascular (CV) events, CV deaths and all-cause deaths in community-dwelling participants of a cardiovascular disease (CVD) prevention programme delivered in a primary care setting. Methods…
View article: Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms
Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms Open
Objective Immunoglobulin M antibodies against phosphorylcholine (anti‐ PC s) may be protective in atherosclerosis, cardiovascular disease ( CVD ), and systemic lupus erythematosus ( SLE ). We study immunoglobulin G1 (IgG1) and immunoglobul…
View article: Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome – a 20-year follow-up of a population-based cohort of 60-year-olds
Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome – a 20-year follow-up of a population-based cohort of 60-year-olds Open
Aims The purpose of this study was to analyse the association of leisure-time physical activity of different intensities at baseline, and cardiovascular disease incidence, cardiovascular disease mortality and all-cause mortality in a popul…
View article: Risk of fall injuries with concomitant use of antidepressants and CYP2D6 inhibitors
Risk of fall injuries with concomitant use of antidepressants and CYP2D6 inhibitors Open
Background: With an aging population, morbidity, fall injuries, polypharmacy and risk of drug-drug interactions increase. The risk of adverse drug-drug interactions (DDIs) increases with more frequent polypharmacy. Antidepressants have bee…
View article: IgM antibodies to oxidized phosphatidylserine as protection markers in cardiovascular disease among 60-year olds
IgM antibodies to oxidized phosphatidylserine as protection markers in cardiovascular disease among 60-year olds Open
IgM anti-OxPS is a novel potential protection marker for CVD, in particular in men. Increased phagocytosis of dying/dead cells could be one potential underlying mechanism.
View article: Serum Fatty Acids, Desaturase Activities and Abdominal Obesity – A Population-Based Study of 60-Year Old Men and Women
Serum Fatty Acids, Desaturase Activities and Abdominal Obesity – A Population-Based Study of 60-Year Old Men and Women Open
Abdominal obesity is a key contributor of metabolic disease. Recent trials suggest that dietary fat quality affects abdominal fat content, where palmitic acid and linoleic acid influence abdominal obesity differently, while effects of n-3 …
View article: Human IgM Antibodies to Malondialdehyde Conjugated With Albumin Are Negatively Associated With Cardiovascular Disease Among 60‐Year‐Olds
Human IgM Antibodies to Malondialdehyde Conjugated With Albumin Are Negatively Associated With Cardiovascular Disease Among 60‐Year‐Olds Open
Background Malondialdehyde ( MDA ) is generated during lipid peroxidation as in oxidized low‐density lipoprotein, but antibodies against oxidized low‐density lipoprotein show variable results in clinical studies. We therefore studied the r…