Max W. Chang
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View article: Loss of tight junction protein claudin 18 uncovers alveolar epithelial stem cell plasticity and emergence of non-fibrogenic transitional progenitors
Loss of tight junction protein claudin 18 uncovers alveolar epithelial stem cell plasticity and emergence of non-fibrogenic transitional progenitors Open
SUMMARY Persistence of senescent alveolar transitional progenitors following lung injury is implicated in the pathogenesis of fibrosis. We identified transitional cells in uninjured Cldn18 knockout (KO) mouse lungs distinct from previously…
View article: Acetylated chitosan scaffolds modulate the micro-environment and promote peripheral nerve regeneration through macrophage TLR2/4 pathway activation
Acetylated chitosan scaffolds modulate the micro-environment and promote peripheral nerve regeneration through macrophage TLR2/4 pathway activation Open
View article: Integrative multi-omics analysis in vivo identifies influenza virus host factors
Integrative multi-omics analysis in vivo identifies influenza virus host factors Open
View article: Position-dependent function of human sequence-specific transcription factors
Position-dependent function of human sequence-specific transcription factors Open
View article: Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing Open
View article: Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4
Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4 Open
Triclosan (TCS) is an antimicrobial toxicant found in a myriad of consumer products and has been detected in human tissues, including breastmilk. We have evaluated the impact of lactational TCS on UDP-glucuronosyltransferase 1A1 (UGT1A1) e…
View article: Drug target prediction through deep learning functional representation of gene signatures
Drug target prediction through deep learning functional representation of gene signatures Open
View article: Index
Index Open
Exploring the link between Sustainable Development Goals (SDGs) and the built environment, this erudite Companion provides a comprehensive overview and critical examination of key topics and complex research issues. Structured around the 5…
View article: Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters
Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters Open
Hybrid immunity (vaccination + natural infection) to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity indu…
View article: Drug target prediction through deep learning functional representation of gene signatures
Drug target prediction through deep learning functional representation of gene signatures Open
Many machine learning applications in bioinformatics currently rely on gene identities extracted from input gene signatures, and fail to take advantage of preexisting knowledge about gene functions. We developed the Functional Representati…
View article: Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development
Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development Open
Exposure to iAs in neonatal mice resulted in excessive accumulation of fat in enterocytes, disrupting lipid homeostasis in the serum and liver, revealing the importance of the gut-liver axis and endoplasmic reticulum stress in mediating iA…
View article: Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters
Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters Open
Hybrid immunity to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity induction. mRNA vaccine, BNT162b2, was…
View article: SARS-CoV-2 Ancestral and Variant of Concern Breakthrough infections boost both cross-reactive cellular and humoral immune responses in mRNA-vaccinated Hamsters
SARS-CoV-2 Ancestral and Variant of Concern Breakthrough infections boost both cross-reactive cellular and humoral immune responses in mRNA-vaccinated Hamsters Open
When mRNA vaccines were rolled out under EUA, it was observed that a single vaccination, already protected vaccinees from severe disease, even before neutralizing antibodies appearded. To better understand the underlying mechanism of prote…
View article: PRESTO: A Multilingual Dataset for Parsing Realistic Task-Oriented Dialogs
PRESTO: A Multilingual Dataset for Parsing Realistic Task-Oriented Dialogs Open
Research interest in task-oriented dialogs has increased as systems such as Google Assistant, Alexa and Siri have become ubiquitous in everyday life. However, the impact of academic research in this area has been limited by the lack of dat…
View article: Oral arsenic administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR
Oral arsenic administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR Open
View article: Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients
Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients Open
Transcription factor programs mediating the immune response to coronavirus disease 2019 (COVID-19) are not fully understood. Capturing active transcription initiation from cis-regulatory elements such as enhancers and promoters by capped s…
View article: PRESTO: A Multilingual Dataset for Parsing Realistic Task-Oriented Dialogs
PRESTO: A Multilingual Dataset for Parsing Realistic Task-Oriented Dialogs Open
Rahul Goel, Waleed Ammar, Aditya Gupta, Siddharth Vashishtha, Motoki Sano, Faiz Surani, Max Chang, HyunJeong Choe, David Greene, Chuan He, Rattima Nitisaroj, Anna Trukhina, Shachi Paul, Pararth Shah, Rushin Shah, Zhou Yu. Proceedings of th…
View article: Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome
Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome Open
View article: Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction
Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction Open
Substance abuse and addiction represent a significant public health problem that impacts multiple dimensions of society, including healthcare, the economy, and the workforce. In 2021, over 100,000 drug overdose deaths were reported in the …
View article: Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction
Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction Open
Substance abuse and addiction represent a significant public health problem that impacts multiple dimensions of society, including healthcare, the economy, and the workforce. In 2021, over 100,000 drug overdose deaths were reported in the …
View article: Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection
Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection Open
Ly6C hi inflammatory monocytes show high IFN responses, and contribute to both protective and pathogenic functions following influenza virus infection. In order to understand the significance of IFN responses in this subset, we examined mo…
View article: Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy Open
View article: Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19
Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19 Open
The contribution of transcription factors (TFs) and gene regulatory programs in the immune response to COVID-19 and their relationship to disease outcome is not fully understood. Analysis of genome-wide changes in transcription at both pro…
View article: Functional landscape of SARS-CoV-2 cellular restriction
Functional landscape of SARS-CoV-2 cellular restriction Open
A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular effectors that go…
View article: Functional Landscape of SARS-CoV-2 Cellular Restriction
Functional Landscape of SARS-CoV-2 Cellular Restriction Open
SUMMARY A deficient interferon response to SARS-CoV-2 infection has been implicated as a determinant of severe COVID-19. To identify the molecular effectors that govern interferon control of SARS-CoV-2 infection, we conducted a large-scale…
View article: Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs
Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs Open
View article: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing Open
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has triggered an ongoing global pandemic of the severe pneumonia-like disease coronavirus disease 2019 (COVID-19)1. The development of a vacci…
View article: Influenza Virus Usurps an Interferon-Induced Translational Program to Promote Viral Replication
Influenza Virus Usurps an Interferon-Induced Translational Program to Promote Viral Replication Open
Hosts mount prudently tuned responses to viral infection in an attempt to block nearly every step of the replication cycle. Viruses must adapt to replicate in this hostile antiviral cellular state. Interferon stimulation or pathogen challe…
View article: A Genome-Wide CRISPR-Cas9 Screen Reveals the Requirement of Host Cell Sulfation for Schmallenberg Virus Infection
A Genome-Wide CRISPR-Cas9 Screen Reveals the Requirement of Host Cell Sulfation for Schmallenberg Virus Infection Open
SBV is a newly emerging orthobunyavirus (family Peribunyaviridae ) that has spread rapidly across Europe since 2011, resulting in substantial economic losses in livestock farming. In this study, we performed unbiased genome-wide CRISPR-Cas…
View article: Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection Open