Max Winerdal
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View article: Diagnostic yield of 1000 trio analyses with exome and genome sequencing in a clinical setting
Diagnostic yield of 1000 trio analyses with exome and genome sequencing in a clinical setting Open
Introduction A trio analysis refers to the strategy of exome or genome sequencing of DNA from a patient, as well as parents, in order to identify the genetic cause of a disorder or syndrome. Methods During the last 10 years, we have succes…
View article: Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Supplemental figure 1 illustrates gating strategy appliead to FACS data. Supplemental figure 2 shows gene expression correlation to Treg frequency overlaid on KEGG bladder cancer pathway. Supplemental figure 3 shows expression of functiona…
View article: Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Table S1 shows patient characteristics. Table S2 summarizes the antibodies used. Table S3 shows primer sequences used.
View article: Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Table S1 shows patient characteristics. Table S2 summarizes the antibodies used. Table S3 shows primer sequences used.
View article: Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of …
View article: Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Supplemental figure 1 illustrates gating strategy appliead to FACS data. Supplemental figure 2 shows gene expression correlation to Treg frequency overlaid on KEGG bladder cancer pathway. Supplemental figure 3 shows expression of functiona…
View article: Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of …
View article: Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications
Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications Open
Patients undergoing major surgery experience postoperative inflammation, which may contribute to postoperative morbidity. Endogenous glucocorticoids (GCs) are an essential part of the stress response, but this response varies between indiv…
View article: Tumour‐associated B cells in urothelial urinary bladder cancer
Tumour‐associated B cells in urothelial urinary bladder cancer Open
Tumour infiltrating B cells and CD38 + plasma cells have been correlated with survival in different malignancies but their role in urinary bladder cancer is unclear. IL‐10 is a multifunctional cytokine with both anti‐inflammatory and immun…
View article: Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway
Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway Open
The immune system plays a significant role in urothelial bladder cancer (UBC) progression, with CD8+ T cells being capable to directly kill tumor cells using perforin and granzymes. However, tumors avoid immune recognition by escape mechan…
View article: Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia Open
In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment s…
View article: Single dose caffeine protects the neonatal mouse brain against hypoxia ischemia - Flow cytometric data
Single dose caffeine protects the neonatal mouse brain against hypoxia ischemia - Flow cytometric data Open
Caffeine 5mg/kg or phosphate buffered saline given directly after sham operation or brain hypoxia ischemia. Flow cytometric evaluation of brain immune cell content 24h, 72h and 2 weeks after brain injury.