Mi Yang
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View article: Rapid, low-cost colorimetric detection of <i>Salmonella</i> Typhi bacteriophages for environmental surveillance
Rapid, low-cost colorimetric detection of <i>Salmonella</i> Typhi bacteriophages for environmental surveillance Open
Typhoid fever remains a global public health challenge, especially in low- and middle-income countries where poor sanitation and limited access to clean water facilitate transmission. The lack of data on disease burden poses a significant …
View article: Typhinder: Rapid, low-cost colorimetric detection of<i>Salmonella</i>Typhi bacteriophages for environmental surveillance
Typhinder: Rapid, low-cost colorimetric detection of<i>Salmonella</i>Typhi bacteriophages for environmental surveillance Open
Typhoid fever remains a global public health challenge, especially in low- and middle-income countries where poor sanitation and limited access to clean water facilitate transmission. The lack of data on disease burden poses a significant …
View article: Supplementary Materials and Methods, Tables 1-3, Figures 1-5 from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma
Supplementary Materials and Methods, Tables 1-3, Figures 1-5 from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma Open
Supplementary Materials and Methods, Tables 1-3, Figures 1-5 from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma
View article: Supplementary Materials and Methods, Tables 1-3, Figures 1-5 from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma
Supplementary Materials and Methods, Tables 1-3, Figures 1-5 from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma Open
Supplementary Materials and Methods, Tables 1-3, Figures 1-5 from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma
View article: Data from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma
Data from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma Open
Tumor endothelial marker 8 (TEM8) was initially identified as a gene overexpressed in the vasculature of human tumors and was subsequently identified as an anthrax toxin receptor. To assess the functional role of TEM8, we dis…
View article: Data from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma
Data from Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma Open
Tumor endothelial marker 8 (TEM8) was initially identified as a gene overexpressed in the vasculature of human tumors and was subsequently identified as an anthrax toxin receptor. To assess the functional role of TEM8, we dis…
View article: Pomegranate peel polyphenols alleviate insulin resistance through the promotion of insulin signaling pathway in skeletal muscle of metabolic syndrome rats
Pomegranate peel polyphenols alleviate insulin resistance through the promotion of insulin signaling pathway in skeletal muscle of metabolic syndrome rats Open
Insulin resistance (IR) has been considered to be an important causative factor of metabolic syndrome (MetS). The present study investigated whether pomegranate peel polyphenols (PPPs) could prevent the development of MetS by improving IR …
View article: A dual-targeted molecular therapy of PP242 and cetuximab plays an anti-tumor effect through EGFR downstream signaling pathways in colorectal cancer
A dual-targeted molecular therapy of PP242 and cetuximab plays an anti-tumor effect through EGFR downstream signaling pathways in colorectal cancer Open
Our research further demonstrates the effectiveness of the combined application of CTX and PP242 in inhibiting CRC cell lines from the perspective of cell proliferation, cell cycle, apoptosis, and mouse xenografts. We revealed that the com…
View article: Deciphering the signaling network of breast cancer improves drug sensitivity prediction
Deciphering the signaling network of breast cancer improves drug sensitivity prediction Open
View article: Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics
Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics Open
Cancer is driven by genomic alterations, but the processes causing this disease are largely performed by proteins. However, proteins are harder and more expensive to measure than genes and transcripts. To catalyze developments of methods t…
View article: DreamAI: algorithm for the imputation of proteomics data
DreamAI: algorithm for the imputation of proteomics data Open
Deep proteomics profiling using labeled LC-MS/MS experiments has been proven to be powerful to study complex diseases. However, due to the dynamic nature of the discovery mass spectrometry, the generated data contain a substantial fraction…
View article: Stratification and prediction of drug synergy based on target functional similarity
Stratification and prediction of drug synergy based on target functional similarity Open
View article: CELLector: Genomics-Guided Selection of Cancer In Vitro Models
CELLector: Genomics-Guided Selection of Cancer In Vitro Models Open
View article: Deciphering the Signaling Network Landscape of Breast Cancer Improves Drug Sensitivity Prediction
Deciphering the Signaling Network Landscape of Breast Cancer Improves Drug Sensitivity Prediction Open
Although genetic and epigenetic abnormalities in breast cancer have been extensively studied, it remains difficult to identify those patients who will respond to particular therapies. This is due in part to our lack of understanding of how…
View article: Assessment of the Limits of Predictability of Protein and Phosphorylation Levels in Cancer
Assessment of the Limits of Predictability of Protein and Phosphorylation Levels in Cancer Open
View article: Author Correction: Linking drug target and pathway activation for effective therapy using multi-task learning
Author Correction: Linking drug target and pathway activation for effective therapy using multi-task learning Open
View article: Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4/NF-κB pathway activation
Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4/NF-κB pathway activation Open
The results indicated that PPPs possess potent anti-inflammatory effect, and PC was the main effective component in PPPs, which provided new insights into the utilization of PPPs to prevent inflammation-associated disorders.
View article: Stratification and prediction of drug synergy based on target functional similarity
Stratification and prediction of drug synergy based on target functional similarity Open
Targeted mono-therapies in cancer are hampered by the ability of tumor cells to escape inhibition through rewiring or alternative pathways. Drug combination approaches can provide a means to overcome these resistance mechanisms. Effective …
View article: Multi-omic measurements of heterogeneity in HeLa cells across laboratories
Multi-omic measurements of heterogeneity in HeLa cells across laboratories Open
View article: Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant <i>Enterococcus faecalis</i> Strains in Chongqing, China
Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant <i>Enterococcus faecalis</i> Strains in Chongqing, China Open
optrA plays an important role in linezolid resistance and may serve as a marker for resistance screening. Since the L3 and L4 mutations did not simultaneously occur in the same strain, they play a negligible role in linezolid resist…
View article: In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens
In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens Open
The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partia…
View article: <i>In silico</i>prioritization of transporter-drug relationships from drug sensitivity screens
<i>In silico</i>prioritization of transporter-drug relationships from drug sensitivity screens Open
The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partia…
View article: Quantitative Proteomics Analysis of Membrane Proteins in Enterococcus faecalis With Low-Level Linezolid-Resistance
Quantitative Proteomics Analysis of Membrane Proteins in Enterococcus faecalis With Low-Level Linezolid-Resistance Open
Despite increasing reports of low-level linezolid-resistant enterococci worldwide, the mechanism of this resistance remains poorly understood. Previous transcriptome studies of low-level linezolid-resistant Enterococcus faecalis iso…
View article: Linking drug target and pathway activation for effective therapy using multi-task learning
Linking drug target and pathway activation for effective therapy using multi-task learning Open
Despite the abundance of large-scale molecular and drug-response data, the insights gained about the mechanisms underlying treatment efficacy in cancer has been in general limited. Machine learning algorithms applied to those datasets most…
View article: Genomic, Proteomic and Phenotypic Heterogeneity in HeLa Cells across Laboratories: Implications for Reproducibility of Research Results
Genomic, Proteomic and Phenotypic Heterogeneity in HeLa Cells across Laboratories: Implications for Reproducibility of Research Results Open
The independent reproduction of research results is a cornerstone of experimental research, yet it is beset by numerous challenges, including the quality and veracity of reagents and materials. Much of life science research depends on life…
View article: CELLector: Genomics Guided Selection of Cancer in vitro Models
CELLector: Genomics Guided Selection of Cancer in vitro Models Open
The selection of appropriate cancer models is a key prerequisite for maximising translational potential and clinical relevance of in vitro oncology studies. We developed CELLector: a computational method (implemented in an open source R Sh…
View article: Linking drug target and pathway activation for effective therapy using multi-task learning
Linking drug target and pathway activation for effective therapy using multi-task learning Open
Despite the abundance of large-scale molecular and drug-response data, the insights gained about the mechanisms underlying treatment efficacy in cancer has been in general limited. Machine learning algorithms applied to those datasets most…
View article: Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells
Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells Open
Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 colorectal cancer c…
View article: Genomic determinants of protein abundance variation in colorectal cancer cells
Genomic determinants of protein abundance variation in colorectal cancer cells Open
Summary Assessing the extent to which genomic alterations compromise the integrity of the proteome is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling and tribrid mass spectrometry …
View article: Looking beyond the cancer cell for effective drug combinations
Looking beyond the cancer cell for effective drug combinations Open