Maxim Igaev
YOU?
Author Swipe
Microtubule dynamics are defined by conformations and stability of clustered protofilaments Open
Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions between them are linked to GTP hydrolysis. Recent evidence suggests that flexible tubulin protof…
Microtubule dynamics are defined by conformations and stability of clustered protofilaments Open
Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening and transitions between them are linked to GTP hydrolysis. Recent evidence suggests that flexible tubulin protofi…
Bending-torsional elasticity and energetics of the plus-end microtubule tip Open
Significance The mechanochemical basis of microtubule growth, which is essential for the normal function and division of eukaryotic cells, has remained elusive and controversial, despite extensive work. In particular, recent findings have …
Bending-torsional elasticity and energetics of the plus-end microtubule tip Open
Microtubules (MTs), mesoscopic cellular filaments, grow primarily by the addition of GTP-bound tubulin dimers at their dynamic flaring plus-end tips. They operate as chemomechanical energy transducers with stochastic transitions to an asto…
Choice of fluorophore affects dynamic DNA nanostructures Open
The ability to dynamically remodel DNA origami structures or functional nanodevices is highly desired in the field of DNA nanotechnology. Concomitantly, the use of fluorophores to track and validate the dynamics of such DNA-based architect…
Choice of fluorophore affects dynamic DNA nanostructures Open
The ability to dynamically remodel DNA origami structures or functional nanodevices is highly desired in the field of DNA nanotechnology. Concomitantly, the use of fluorophores to track and validate the dynamics of such DNA-based architect…
View article: 2019 EMDataResource Model Metrics Challenge Dataset
2019 EMDataResource Model Metrics Challenge Dataset Open
This is the full dataset of the 2019 Cryo-EM Map-based Model Metrics Challenge sponsored by EMDataResource (www.emdataresource.org, challenges.emdataresource.org, model-compare.emdataresource.org). The goals of this challenge were (1) to a…
View article: 2019 EMDataResource Model Metrics Challenge Dataset
2019 EMDataResource Model Metrics Challenge Dataset Open
This is the full dataset of the 2019 Cryo-EM Map-based Model Metrics Challenge sponsored by EMDataResource (www.emdataresource.org, challenges.emdataresource.org, model-compare.emdataresource.org). The goals of this challenge were (1) to a…
Microtubule instability driven by longitudinal and lateral strain propagation Open
Tubulin dimers associate longitudinally and laterally to form metastable microtubules (MTs). MT disassembly is preceded by subtle structural changes in tubulin fueled by GTP hydrolysis. These changes render the MT lattice unstable, but it …
View article: Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution
Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution Open
This paper describes outcomes of the 2019 Cryo-EM Map-based Model Metrics Challenge sponsored by EMDataResource ( www.emdataresource.org ). The goals of this challenge were (1) to assess the quality of models that can be produced using cur…
Microtubule instability driven by longitudinal and lateral strain propagation Open
Tubulin dimers associate longitudinally and laterally to form metastable microtubules (MTs). MT disassembly is preceded by subtle structural changes in tubulin fueled by GTP hydrolysis. These changes render the MT lattice unstable, but it …
SESCA: Predicting Circular Dichroism Spectra from\nProtein Molecular Structures Open
Circular\ndichroism (CD) spectroscopy is a highly sensitive but\nlow-resolution technique to study the structure of proteins. Combined\nwith molecular modeling or other complementary techniques, CD spectroscopy\ncan provide essential infor…
SESCA: Predicting Circular Dichroism Spectra from Protein Molecular Structures Open
Circular dichroism (CD) spectroscopy is a highly sensitive but low-resolution technique to study the structure of proteins. Combined with molecular modeling or other complementary techniques, CD spectroscopy can provide essential informati…
Automated cryo-EM structure refinement using correlation-driven molecular dynamics Open
We present a correlation-driven molecular dynamics (CDMD) method for automated refinement of atomistic models into cryo-electron microscopy (cryo-EM) maps at resolutions ranging from near-atomic to subnanometer. It utilizes a chemically ac…
Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit Open
Microtubules (MTs) are key components of the cytoskeleton and play a central role in cell division and development. MT assembly is known to be associated with a structural change in -tubulin dimers from kinked to straight conformations. Ho…
Author response: Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Microtubules (MTs) are key components of t…