Maxime A. Siegler
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View article: Visualizing the Invisible: Dual Click Imaging of Ruthenium-Based Photoactivated Chemotherapy Agents and Their DNA Synthesis Inhibition in Fixed Cancer Cells
Visualizing the Invisible: Dual Click Imaging of Ruthenium-Based Photoactivated Chemotherapy Agents and Their DNA Synthesis Inhibition in Fixed Cancer Cells Open
Like many drugs, ruthenium-based photoactivated chemotherapy (PACT) complexes are hard to follow in cells due to their absence of emissive properties. Here, two alkyne-functionalized Ru-based PACT compounds with the formula [Ru(HCC-tpy)(N̂N…
View article: Structure over States: Planarity, Not Energy, Dictates Photoactivation in Ru(II) PACT Agents
Structure over States: Planarity, Not Energy, Dictates Photoactivation in Ru(II) PACT Agents Open
Photoactivated chemotherapy (PACT) employs light to precisely control the activity of prodrugs, enabling spatial and temporal regulation of therapeutic effects while minimizing systemic toxicity. Transition-metal complexes, particularly Ru…
View article: Stepwise 6H<sup>+</sup>/6e<sup>–</sup> Electron-Coupled Proton Buffers Based on Fe and Redox-Active Ligands
Stepwise 6H<sup>+</sup>/6e<sup>–</sup> Electron-Coupled Proton Buffers Based on Fe and Redox-Active Ligands Open
Herein, we report electron-coupled-proton buffers (ECPBs) based on Fe and redox-active ortho-phenylenediamine (opda) ligands that perform stepwise and reversible 6H+/6e- transformations. Four of the Fe complexe…
View article: Monoterpenoid fluorophthalimide IMiDs that lack human cereblon binding: synthesis and anti-proliferative, anti-angiogenic and anti-inflammatory activities
Monoterpenoid fluorophthalimide IMiDs that lack human cereblon binding: synthesis and anti-proliferative, anti-angiogenic and anti-inflammatory activities Open
View article: Homologous Ladder Cyclohexasilanes
Homologous Ladder Cyclohexasilanes Open
We report the synthesis of five new examples of ladder cyclohexasilanes, possessing up to three consecutive fused rings and differing in relative ring fusion configuration and side chain structure. By coupling a 1,4‐dipotassiooligosilyl di…
View article: Symmetry-mediated quantum coherence of W5+ spins in an oxygen-deficient double perovskite
Symmetry-mediated quantum coherence of W5+ spins in an oxygen-deficient double perovskite Open
Elucidating the factors limiting quantum coherence in real materials is essential to the development of quantum technologies. Here we report a strategic approach to determine the effect of lattice dynamics on spin coherence lifetimes using…
View article: Synthesis and Characterization of Copper Complexes Featuring a Redox-Active ONO Ligand in Three Molecular Oxidation States
Synthesis and Characterization of Copper Complexes Featuring a Redox-Active ONO Ligand in Three Molecular Oxidation States Open
In this research article, we report the synthesis, characterization, and reactivity of a family of Cu complexes bearing a tridentate iminosemiquinone ligand and ancillary amine ligands ((sqONO)CuII(L)n
View article: Single-Wavelength Visible-Light-Induced Reversible Isomerization of Stiff-Stilbene under Dynamic Covalent Control
Single-Wavelength Visible-Light-Induced Reversible Isomerization of Stiff-Stilbene under Dynamic Covalent Control Open
Formylation of stiff-stilbene enables isomerization by visible instead of UV light, as is monitored by UV-vis and 1H NMR spectroscopy. Further, it allows dynamic covalent imine formation, which gives rise to slightly blue-shifte…
View article: A photoswitchable [2]catenane receptor
A photoswitchable [2]catenane receptor Open
Photoisomerization of a [2]catenane-based receptor functionalized with stiff-stilbene allows for on demand uptake and release of chloride ions.
View article: Type I and type II superconductivity in a quasi-2D Dirac metal
Type I and type II superconductivity in a quasi-2D Dirac metal Open
Dirac material LaCuSb 2 shows anisotropic superconducting response to applied magnetic fields.
View article: Symmetry-mediated quantum coherence of $W^{5+}$ spins in an oxygen-deficient double perovskite
Symmetry-mediated quantum coherence of $W^{5+}$ spins in an oxygen-deficient double perovskite Open
Elucidating the factors limiting quantum coherence in real materials is essential to the development of quantum technologies. Here we report a strategic approach to determine the effect of lattice dynamics on spin coherence lifetimes using…
View article: Enhanced Proton-Coupled Electron-Transfer Reactivity by a Mononuclear Nickel(II) Hydroxide Radical Complex
Enhanced Proton-Coupled Electron-Transfer Reactivity by a Mononuclear Nickel(II) Hydroxide Radical Complex Open
The synthesis, characterization, and reactivity of a NiOH core bearing a tridentate redox-active ligand capable of reaching three molecular oxidation states is presented in this paper. The reduced complex [LNiOH]2- was character…
View article: Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent
Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent Open
The mobility of proteins in the bilayer membrane is affected by (local) changes in lipid environment, which is important to their biological functioning. Artificial molecular systems that—to some extent—imitate tasks of membrane‐embedded p…
View article: Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent
Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent Open
The mobility of proteins in the bilayer membrane is affected by (local) changes in lipid environment, which is important to their biological functioning. Artificial molecular systems that—to some extent—imitate tasks of membrane‐embedded p…
View article: Activity Control of a Synthetic Transporter by Photodynamic Modulation of Membrane Mobility and Incorporation
Activity Control of a Synthetic Transporter by Photodynamic Modulation of Membrane Mobility and Incorporation Open
Artificial transmembrane transport systems are receiving a great deal of attention for their potential therapeutic application. A major challenge is to switch their activity in response to environmental stimuli, which has been achieved mos…
View article: Random-exchange Heisenberg behavior in the electron-doped quasi-one-dimensional spin-1 chain compound <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mi>AgVP</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">S</mml:mi><mml:mn>6</mml:mn></mml:msub></mml:mrow></mml:math>
Random-exchange Heisenberg behavior in the electron-doped quasi-one-dimensional spin-1 chain compound Open
Recent theoretical work suggests that a pair-density wave superconducting state can be realized by doping a one-dimensional spin-1 chain. Here, we report the physical properties of single crystals of MgxAg1–xVP2<…
View article: Controlling Charged State Colors in Triphenylamine‐Based Anodically Coloring Electrochromes
Controlling Charged State Colors in Triphenylamine‐Based Anodically Coloring Electrochromes Open
A series of anodically coloring electrochromic molecules comprised of thioalkyl‐substituted 3,4‐ethylenedioxythiophenes coupled to triphenylamine units that vary in position and degree of electron rich character of the substituents are rep…
View article: Oxygen-Dependent Interactions between the Ruthenium Cage and the Photoreleased Inhibitor in NAMPT-Targeted Photoactivated Chemotherapy
Oxygen-Dependent Interactions between the Ruthenium Cage and the Photoreleased Inhibitor in NAMPT-Targeted Photoactivated Chemotherapy Open
Photoactivated chemotherapy agents form a new branch of physically targeted anticancer agents with potentially lower systemic side effects for patients. On the other hand, limited information exists on the intracellular interactions betwee…
View article: Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor U2AF1 in Leukemia Cells
Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor U2AF1 in Leukemia Cells Open
Mutations in RNA splicing factor genes including SF3B1, U2AF1, SRSF2, and ZRSR2 have been reported to contribute to development of myeloid neoplasms including myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML). Chem…
View article: Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H<sub>2</sub>S Mediated Persulfidation
Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H<sub>2</sub>S Mediated Persulfidation Open
The gasotransmitter hydrogen sulfide (H 2 S) is thought to be involved in the post‐translational modification of cysteine residues to produce reactive persulfides. A persulfide‐specific chemoselective proteomics approach with mammalian cel…
View article: Tuning the Thermochemistry and Reactivity of a Series of Cu-Based 4H<sup>+</sup>/4e<sup>–</sup> Electron-Coupled-Proton Buffers
Tuning the Thermochemistry and Reactivity of a Series of Cu-Based 4H<sup>+</sup>/4e<sup>–</sup> Electron-Coupled-Proton Buffers Open
Electron-coupled-proton buffers (ECPBs) store and deliver protons and electrons in a reversible fashion. We have recently reported an ECPB based on Cu and a redox-active ligand that promoted 4H+/4e- reversible transfo…
View article: Hydroflux-Controlled Growth of Magnetic K-Cu-Te-O(H) Phases
Hydroflux-Controlled Growth of Magnetic K-Cu-Te-O(H) Phases Open
Innovative synthetic approaches can yield new phases containing novel structural and magnetic motifs. In this work, we show the synthesis and magnetic characterization of three new and one previously reported layered phase in the K-Cu-Te-O…
View article: Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy
Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy Open
Photoactivated chemotherapy agents show a promising ability to kill cancer cells under the action of light, including those in chronic hypoxic conditions. Those compounds form a new branch of physically targeted anticancer agents with pote…
View article: A Nonheme Iron(III) Superoxide Complex Leads to Sulfur Oxygenation
A Nonheme Iron(III) Superoxide Complex Leads to Sulfur Oxygenation Open
A new alkylthiolate-ligated nonheme iron complex, FeII(BNPAMe2S)Br (1), is reported. Reaction of 1 with O2 at -40 °C, or reaction of the ferric form with O2•- at -80 °C, …
View article: CCDC 2277308: Experimental Crystal Structure Determination
CCDC 2277308: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2277307: Experimental Crystal Structure Determination
CCDC 2277307: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2277309: Experimental Crystal Structure Determination
CCDC 2277309: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2277310: Experimental Crystal Structure Determination
CCDC 2277310: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2300376: Experimental Crystal Structure Determination
CCDC 2300376: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: PhenTAA: A Redox-Active N<sub>4</sub>-Macrocyclic Ligand Featuring Donor and Acceptor Moieties
PhenTAA: A Redox-Active N<sub>4</sub>-Macrocyclic Ligand Featuring Donor and Acceptor Moieties Open
Here, we present the development and characterization of the novel PhenTAA macrocycle as well as a series of [Ni(R2PhenTAA)]n complexes featuring two sites for ligand-centered redox-activity. These differ in the subst…