Maxime Annereau
YOU?
Author Swipe
View article: A risk-based, QTPP-driven framework for semi-solid extrusion 3d printing of personalized medicines: Integrating hospital compounding and clinical trial regulation
A risk-based, QTPP-driven framework for semi-solid extrusion 3d printing of personalized medicines: Integrating hospital compounding and clinical trial regulation Open
Semi-solid extrusion (SSE) 3D printing enables precise, patient-specific oral medicines, yet its uptake is constrained by fragmented regulatory pathways. This study develops an applied, risk-based framework grounded in empirical data from …
View article: Hybrid GPP–hospital control strategy for semi-solid extrusion 3D printing of ONC201 chewable units in pediatric oncology
Hybrid GPP–hospital control strategy for semi-solid extrusion 3D printing of ONC201 chewable units in pediatric oncology Open
Children with central nervous system tumors often face significant barriers to age-appropriate medicines, especially when dysphagia prevents the use of conventional tablets or capsules. ONC201 (dordaviprone), a first-in-class imipridone av…
View article: Ensuring quality control in HME, a quantitative analysis of hydrocortisone filament using a portable Raman spectrometer
Ensuring quality control in HME, a quantitative analysis of hydrocortisone filament using a portable Raman spectrometer Open
3D printing is a breakthrough in drug development, offering advantages like personalized medication and the ability to create complex drug formulations. Ensuring safety and efficacy of these printed medications requires rigorous quality co…
View article: A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology
A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology Open
Background/Objectives: Hospital compounding is essential for the delivery of patient-tailored therapies—particularly for pediatric and oncology patients and other groups requiring precise dosing. Its role is expected to grow as, for instan…
View article: 12P ORGANOTREAT-01: A pioneer phase I/II multicenter trial of organoid-driven precision medicine for refractory colorectal cancer
12P ORGANOTREAT-01: A pioneer phase I/II multicenter trial of organoid-driven precision medicine for refractory colorectal cancer Open
View article: 3D printing personalized medications in a hospital: Rapid and non-destructive dose verification of printed medicines enabled by miniaturised spectroscopy
3D printing personalized medications in a hospital: Rapid and non-destructive dose verification of printed medicines enabled by miniaturised spectroscopy Open
Three-dimensional printing (3DP) of pharmaceuticals is as an enabling technology for personalised medicine and is a versatile production technology for compounding automation and decentralised manufacture. However, non-destructive quality …
View article: Stability-Guided Formulation of a Light-Sensitive D-LSD Capsule for Clinical Investigation
Stability-Guided Formulation of a Light-Sensitive D-LSD Capsule for Clinical Investigation Open
Background/Objectives: D-lysergic acid diethylamide (D-LSD) is under investigation as a potential therapeutic strategy for alcohol use disorder (AUD). However, the extreme light sensitivity of D-LSD presents a significant challenge in deve…
View article: Clinical implementation of a paediatric 3D-printed combination of Sulfamethoxazole and Trimethoprim
Clinical implementation of a paediatric 3D-printed combination of Sulfamethoxazole and Trimethoprim Open
View article: Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug
Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug Open
Orodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It is administered by mouth, where it dissolves, making it suitable for children. Objectives: The aim of the stu…
View article: Real life data of ONC201 (dordaviprone) in pediatric and adult H3K27-altered recurrent diffuse midline glioma: Results of an international academia-driven compassionate use program
Real life data of ONC201 (dordaviprone) in pediatric and adult H3K27-altered recurrent diffuse midline glioma: Results of an international academia-driven compassionate use program Open
While the efficacy of ONC201 needs validation in a controlled randomized clinical trial, our real-life data support a better outcome for patients with thalamic tumors treated with ONC201. We demonstrated furthermore the feasibility of a su…
View article: Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability
Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability Open
Diffuse intrinsic pontine glioma (DIPG) poses a significant treatment challenge in pediatric patients due to its aggressive nature and difficulty in crossing the blood-brain barrier with effective therapies. ONC201 (dordaviprone) shows pro…
View article: Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS Open
Understanding drug behavior within the skin, especially for photosensitive compounds, is crucial for developing effective and safe topical therapies. This study employs Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging …
View article: The promising role of semi-solid extrusion technology in custom drug formulation for pediatric medicine
The promising role of semi-solid extrusion technology in custom drug formulation for pediatric medicine Open
The long-standing issue of inadequate medicine formulations has been a focus of regulatory bodies and pharmaceutical research, particularly in adapting medicines for children’s unique requirements. The pediatric population presents d…
View article: High accuracy discriminant analysis of preparation from 22 commercial antibodies based on UV spectroscopy combined with chemometrics
High accuracy discriminant analysis of preparation from 22 commercial antibodies based on UV spectroscopy combined with chemometrics Open
View article: Developing an innovative 3D printing platform for production of personalised medicines in a hospital for the OPERA clinical trial
Developing an innovative 3D printing platform for production of personalised medicines in a hospital for the OPERA clinical trial Open
Breast cancer is the most frequently diagnosed cancer in women worldwide, and non-adherence to adjuvant hormonotherapy can negatively impact cancer recurrence and relapse. Non-adherence is associated with side effects of hormonotherapy. Ph…
View article: SIOPE and ESOP recommendations for extemporaneous compounding of oral liquid medicine formulations in paediatric oncology
SIOPE and ESOP recommendations for extemporaneous compounding of oral liquid medicine formulations in paediatric oncology Open
Introduction: Scarcity of age appropriate formulations for orally administered medicines for paediatric malignancies is a critical and ongoing issue which necessitates urgent solutions. According to JARC Survey 27 % of oral medicines were …
View article: Codon-specific KRAS mutations predict survival in advanced pancreatic cancer
Codon-specific KRAS mutations predict survival in advanced pancreatic cancer Open
Background: How distinct KRAS alterations in pancreatic adenocarcinoma (PDAC) influence tumor initiation and outcomes remains unclear. Moreover, KRAS is now partly targetable with novel specific inhibitors targeting KRASG12 (G12C or G12D),…
View article: High Accuracy Discriminant Analysis of Preparation from 22 Commercial Antibodies Based on Uv Spectroscopy Combined with Chemometrics
High Accuracy Discriminant Analysis of Preparation from 22 Commercial Antibodies Based on Uv Spectroscopy Combined with Chemometrics Open
View article: Dispensing Oral Temozolomide in Children: Precision and Stability of a Novel and Ready to Use Liquid Formulation in Comparison with Capsule Derived Mixtures
Dispensing Oral Temozolomide in Children: Precision and Stability of a Novel and Ready to Use Liquid Formulation in Comparison with Capsule Derived Mixtures Open
Temozolomide (TMZ) is part of the therapeutic armamentarium used in managing pediatric cancers; however, available oral forms (capsules) are not adapted for use in children. Our aim was to assess the dose accuracy and stability of TMZ usin…
View article: Implementing patient derived organoids in functional precision medicine for patients with advanced colorectal cancer
Implementing patient derived organoids in functional precision medicine for patients with advanced colorectal cancer Open
Background Patient Derived Organoids (PDOs) emerged as the best technology to develop ex vivo tumor avatars. Whether drug testing on PDOs to identify efficient therapies will bring clinical utility by improving patient survival remains unc…
View article: Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution
Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution Open
Glioblastoma is one of the most common and aggressive forms of brain tumor, a rare disease for which there is a great need for innovative therapies. ONC201, a new drug substance, has been used in a compassionate treatment program where the…
View article: Identification of Degradation Products of the New Anticancer Drug Substance ONC201 by Liquid Chromatography–High-Resolution Multistage Mass Spectrometry
Identification of Degradation Products of the New Anticancer Drug Substance ONC201 by Liquid Chromatography–High-Resolution Multistage Mass Spectrometry Open
ONC201 (dordaviprone) is a new drug substance used in a compassionate manner to treat patients with glioblastoma. Given the clinical context and the particularly promising preclinical results, we have been asked by the medical authorities …
View article: 3D-Printed, Liquid-Filled Capsules of Concentrated and Stabilized Polyphenol Epigallocatechin Gallate, Developed in a Clinical Trial
3D-Printed, Liquid-Filled Capsules of Concentrated and Stabilized Polyphenol Epigallocatechin Gallate, Developed in a Clinical Trial Open
In vitro studies have shown that epigallocatechin gallate (EGCG), the most potent antioxidant of the green tea polyphenol catechins, is able to effectively prevent the formation of amyloid plaques and induce their clearance. However, its h…
View article: Additional file 1 of Implementing patient derived organoids in functional precision medicine for patients with advanced colorectal cancer
Additional file 1 of Implementing patient derived organoids in functional precision medicine for patients with advanced colorectal cancer Open
Additional file 1: Supplementary Table 1. Supplementary clinical data. Supplementary Table 2. Annotations Fig. 2D. Supplementary Table 3. Supplementary clinical concordance data.
View article: Identification of the Major Degradation Pathways of Selumetinib
Identification of the Major Degradation Pathways of Selumetinib Open
Selumetinib is administered orally in capsule form and is indicated for the treatment of neurofibromatosis. To facilitate dosage adjustments, liquid preparations, such as solutions or suspensions, are to be developed. This led, first, to d…
View article: Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies
Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies Open
Nirmatrelvir is an antiviral drug approved for the treatment of COVID-19. The available dosage form consists of tablets marketed under the brand name PAXLOVID®. Although knowledge of nirmatrelvir’s intrinsic stability may be useful for any…
View article: Development of a Hospital Compounded, Taste-Masked, Temozolomide Oral Suspension and 5-Year Real-Life Experience in Treating Paediatric Patients
Development of a Hospital Compounded, Taste-Masked, Temozolomide Oral Suspension and 5-Year Real-Life Experience in Treating Paediatric Patients Open
The development of oral pediatric forms by pharmaceutical companies is still insufficient. In fact, many drugs used in paediatric oncology, such as temozolomide, are not labeled and adapted for paediatric use. Temozolomide (TMZ) is an alky…
View article: Impression 2D-3D dans les pharmacies hospitalières : quels rôles et quels challenges ?
Impression 2D-3D dans les pharmacies hospitalières : quels rôles et quels challenges ? Open
View article: Clinical significance of the loss of CD20 antigen on tumor cells in patients with relapsed or refractory follicular lymphoma
Clinical significance of the loss of CD20 antigen on tumor cells in patients with relapsed or refractory follicular lymphoma Open
Aim: Anti-CD20 monoclonal antibody is a cornerstone therapy for follicular lymphoma. Following anti-CD20 therapy, a potential decrease in CD20 antigen, and therefore a loss of the tumor target might be expected. However, the inciden…
View article: Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties
Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties Open