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MRI-based classifier to identify close-to-onset cases in <i>C9orf72</i> genetic frontotemporal dementia Open

Mahdie Soltaninejad, Yasser Iturria‐Medina, Reza Rajabli, Gleb Bezgin, Niki Hosseini-Kamkar , et al. · 2025

Predicting symptom onset in genetic frontotemporal dementia (FTD) is crucial for advancing targeted interventions and clinical trial design. Brain changes begin years before clinical symptoms emerge, making neuroimaging a strong candidate …

White matter hyperintensities precede other biomarkers in <i>GRN</i> frontotemporal dementia Open

Mahdie Soltaninejad, Mahsa Dadar, D. Louis Collins, Reza Rajabli, Vikram Venkatraghavan , et al. · 2025

INTRODUCTION Increased white matter hyperintensities (WMHs) have been reported in genetic frontotemporal dementia (FTD) in small studies, but the sequence of WMH abnormalities relative to other biomarkers is unclear. METHODS Using a large …

Cross‐country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia Open

Liset de Boer, Lize C. Jiskoot, Harro Seelaar, John C. van Swieten, Agustín Ibáñez , et al. · 2025

INTRODUCTION We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER acros…

Competitive Bias in Severe Alcohol Use Disorder: Exploration through the Prisoner’s Dilemma Open

Mado Gautier, Maxime Bertoux, Damien Brevers, Nicolas Vinsous, Pierre Maurage · 2025

Aims: Biased social decision-making might play a critical role in interpersonal difficulties and relapse among individuals with severe alcohol use disorder (SAUD), but its exploration remains scarce. We explored social decision-making in S…

BrainAGE latent representation clustering is associated with longitudinal disease progression in early-onset Alzheimer’s disease Open

Dorian Manouvriez, Grégory Kuchcinski, Vincent Roca, Adeline Rollin Sillaire, Maxime Bertoux , et al. · 2025

K-means clustering of BrainAGE encoded representations stratified EOAD patients based on varying rates of disease progression. These findings underscore the potential of using BrainAGE as a biomarker for better understanding and managing E…

Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia Open

Arabella Bouzigues, Vincent Le Du, Matthieu Joulot, Ninon Peysson, Marion Houot , et al. · 2025

INTRODUCTION Microtubule‐associated protein tau ( MAPT ) mutations cause frontotemporal dementia (FTD), characterised by behavioural, language, and motor impairments due to brain connectivity disruptions. We investigated structural and fun…

International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative Open

Alessandra Dodich, Andrea Panzavolta, Giulia Funghi, Claudia Meli, Cristina Festari , et al. · 2025

BACKGROUND: Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for neurocognitive disorders in memory clinics. T…

Anatomical progression of genetic frontotemporal lobar degeneration across the lifespan Open

Vincent Planche, Boris Mansencal, Vladimir Fonov, José V. Manjón, Thomas Tourdias , et al. · 2025

The recent development of brain charts for the human lifespan offers an ideal modelling framework for pathologies such as genetic frontotemporal lobar degeneration (FTLD) which likely involve both neurodevelopmental and neurodegenerative p…

Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders Open

Chiara Cerami, Marina Boccardi, Claudia Meli, Andrea Panzavolta, Giulia Funghi , et al. · 2025

Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments in NCDs seldom include tests exploring social cognitive skills. In 2022, we launched the SIGNATURE i…

Comparing high and low amyloid producers in Alzheimer's disease: An in-depth analysis Open

Mélanie Leroy, Anne Laure Aziz, Susanna Schraen, Vincent Deramecourt, Emilie Skrobala , et al. · 2025

Overall, our study supports the surrogate use of the Aβ_42/40 ratio as an equivalent to Aβ₄₂ to define AD. We showed that HiA CSF profiles were not associated with differences in cognition, brain structures and metabol…

Cellular signatures of functional resilience in presymptomatic frontotemporal dementia Open

Kamen A. Tsvetanov, Maura Malpetti, P Simon Jones, Timothy Rittman, David J. Whiteside , et al. · 2025

Frontotemporal dementia (FTD) shows autosomal dominant transmission in up to a third of families, enabling the study of presymptomatic and prodromal phases. Despite self-reported well-being and normal daily cognitive functioning, brain str…

Harmonizing cross-cultural and transdiagnostic assessment of social cognition by expert panel consensus Open

Amy E. Pinkham, Michal Hajdúk, Tim Ziermans, Minji Bang, Maxime Bertoux , et al. · 2025

Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study Open

Sonja Soskic, Henry F. J. Tregidgo, Emily Todd, Arabella Bouzigues, David M. Cash , et al. · 2025

Thalamic subregions are commonly, but variably, affected by different forms of frontotemporal dementia. We aimed to better characterize thalamic subregional involvement in genetic frontotemporal dementia with a recently published thalamus …

In depth comparisons of neuropsychological & neuroimaging profile of primary psychiatric disorders and behavioral variant FTD Open

Agnès Deneve, Thibaud Lebouvier, Renaud Lopes, Grégory Kuchcinski, Florence Pasquier , et al. · 2024

Background Over the past years, social cognition has been envisaged as a promising domain to distinguish behavioral variant frontotemporal degeneration (bvFTD) from its main differential diagnoses that is primary psychiatric disorders (PPD…

Clinical Recognition of Frontotemporal Dementia with Right Temporal Predominance; Consensus Recommendations of the International Working Group Open

Hülya Ulugut, Kyan Younes, Maxime Montembeault, Maxime Bertoux, Muireann Irish , et al. · 2024

Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International …

Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study Open

Hülya Ulugut, Maxime Bertoux, Kyan Younes, Maxime Montembeault, Giorgio Fumagalli , et al. · 2024

INTRODUCTION Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clin…

Defining key concepts for mental state attribution Open

François Quesque, Ian A. Apperly, Renée Baillargeon, Simon Baron‐Cohen, Cristina Becchio , et al. · 2024

Heterogeneous factors influence social cognition across diverse settings in brain health and age-related diseases Open

Sol Fittipaldi, Agustina Legaz, Marcelo Maito, Hernán Hernandez, Florencia Altschuler , et al. · 2024

Aging diminishes social cognition, and changes in this capacity can indicate brain diseases. However, the relative contribution of age, diagnosis and brain reserve to social cognition, especially among older adults and in global settings, …

Heterogenous factors modulate social cognition across diverse settings in brain health and disease Open

Sol Fittipaldi, Agustina Legaz, Marcelo Maito, Hernán Hernandez, Florencia Altschuler , et al. · 2023

Background Social cognition dysfunction in neurodegenerative diseases such as the behavioral variant frontotemporal dementia (bvFTD) and Alzheimer’s Disease (AD) is typically ascribed to the underlying pathophysiological processes spanning…

Genuine Memory Deficits as Assessed by the Free and Cued Selective Reminding Test (FCSRT) in the Behavioural Variant of Frontotemporal Dementia. A Systematic Review and Meta-analysis Study Open

Luigi Macchitella, Giorgia Tosi, Francesco Giaquinto, Marika Iaia, Ezia Rizzi , et al. · 2023

The current diagnostic criteria for the behavioural variant of frontotemporal dementia (bvFTD) foresee a relative sparing of long-term memory. Although bvFTD patients were thought to report secondary memory deficits associated with prefron…

Heterogeneous factors influence social cognition across diverse settings in brain health and age-related diseases Open

Sol Fittipaldi, Agustina Legaz, Marcelo Maito, Hernán Hernandez, Florencia Altschuler , et al. · 2023

Aging may diminish social cognition, which is crucial for interaction with others, and significant changes in this capacity can indicate pathological processes like dementia. However, the extent to which non-specific factors explain variab…

Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort: comparison with sporadic primary progressive aphasia Open

Kiran Samra, Amy MacDougall, Arabella Bouzigues, Martina Bocchetta, David M. Cash , et al. · 2023

Primary progressive aphasia is most commonly a sporadic disorder, but in some cases, it can be genetic. This study aimed to understand the clinical, cognitive and imaging phenotype of the genetic forms of primary progressive aphasia in com…

Social cognition across bipolar disorder and behavioral variant frontotemporal dementia: an exploratory study Open

Izabela Guimarães Barbosa, Flávia da Mata Chiácchio Leite, Maxime Bertoux, Henrique Cerqueira Guimarães, Luciano Inácio Mariano , et al. · 2023

BD1 and bvFTD share deficits in the core SC functions. These findings should be considered in the development of tasks aiming to improve clinical differentiation between the two disorders.

Zero the hero: Evidence for involvement of the ventromedial prefrontal cortex in affective bias for free items Open

V. Lenglin, Stephanie Wong, Claire O’Callaghan, Sharon Erzinçlioğlu, Michael Hornberger , et al. · 2022

I'm looking through you: Mentalizing in frontotemporal dementia and progressive supranuclear palsy Open

Leonardo Cruz de Souza, Maxime Bertoux, Ratko Radaković, Michael Hornberger, Luciano Inácio Mariano , et al. · 2022

Does culture shape our understanding of others’ thoughts and emotions? An investigation across 12 countries. Open

François Quesque, Antoine Coutrot, Sharon Cox, Leonardo Cruz de Souza, Sandra Báez , et al. · 2022

Overall, these findings highlight the need for important methodological shifts to better represent social cognition in both fundamental research and clinical practice, especially within emerging international networks and consortia. (PsycI…

Social cognition in neuropsychology: A nationwide survey revealing current representations and practices Open

François Quesque, Maxime Nivet, Aurore Etchepare, Grégoire Wauquiez, Antoinette Prouteau , et al. · 2022

As a key domain of cognition, social cognition abilities are altered in a wide range of clinical groups. Accordingly, many clinical tests and theories of social cognition have been developed these last decades. Contrasting this abundant de…

Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia Open

Stefano Gazzina, Mario Grassi, Enrico Premi, Antonella Alberici, Alberto Benussi , et al. · 2022

Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort Open

Phoebe H. Foster, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Arabella Bouzigues , et al. · 2022

Neuropsychologie sociale : limites & défis de l'approche actuelle Open

François Quesque, Maxime Bertoux · 2022

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