Maxime Killer
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View article: Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1
Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1 Open
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persi…
View article: Characterization of binding of diverse peptides to bacterial peptide transporter DtpB using NanoDSF assay
Characterization of binding of diverse peptides to bacterial peptide transporter DtpB using NanoDSF assay Open
For more details please see: Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition https://www.biorxiv.org/content/10.1101/2023.02.14.528348
View article: Characterization of binding of diverse peptides to bacterial peptide transporter DtpB using NanoDSF assay
Characterization of binding of diverse peptides to bacterial peptide transporter DtpB using NanoDSF assay Open
For more details please see: Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition https://www.biorxiv.org/content/10.1101/2023.02.14.528348
View article: Molecular basis of TASL recruitment by PHT1
Molecular basis of TASL recruitment by PHT1 Open
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune response. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persis…
View article: Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition
Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition Open
Summary Proton-coupled oligopeptide transporters (POTs) are promiscuous transporters of the Major Facilitator Superfamily, that constitute the main route of entry for a wide range of dietary peptides and orally administrated peptidomimetic…
View article: Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C
Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C Open
Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS) mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to constitute the most promiscuous class of MFS transporters,…
View article: Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C
Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C Open
Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS) mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to constitute the most promiscuous class of MFS transporters,…
View article: Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes Open
Structures of PepT1 and PepT2 provide mechanistic insights into substrate and drug translocation across epithelial membranes.
View article: Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes Open
The uptake of peptides in mammals plays a crucial role in nutrition and inflammatory diseases. This process is mediated by promiscuous transporters of the Solute Carrier Family 15, which form part of the Major Facilitator superfamily. Besi…
View article: Differential complex formation via paralogs in the human Sin3 protein interaction network
Differential complex formation via paralogs in the human Sin3 protein interaction network Open
Despite the continued analysis of HDAC inhibitor efficacy in clinical trials, the heterogeneous nature of the protein complexes they target limits our understanding of the beneficial and off-target effects associated with their application…