Maxime Parent
YOU?
Author Swipe
View article: VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model Open
Meningeal lymphatic vessels (MLVs) promote tissue clearance and immune surveillance in the central nervous system (CNS). Vascular endothelial growth factor-C (VEGF-C) regulates MLV development and maintenance and has therapeutic potential …
View article: VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes
VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes Open
Meningeal lymphatic vessels promote tissue clearance and immune surveillance in the central nervous system (CNS). Vascular endothelium growth factor-C (VEGF-C) is essential for meningeal lymphatic development and maintenance and has therap…
View article: Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations
Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations Open
The thalamus is a crucial subcortical hub that impacts cortical activity. Tracing experiments in animals and post-mortem humans suggest rich morphological specificity of the thalamus. Very few studies reported rodent thalamic activations b…
View article: Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity Open
Objective The astroglial enzyme glutamine synthetase (GS) is deficient in small loci in the brain in adult patients with different types of focal epilepsy; however, the role of this deficiency in the pathogenesis of epilepsy has been diffi…
View article: Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression
Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression Open
Glioblastoma progression involves multifaceted changes in vascularity, cellularity, and metabolism. Capturing such complexities of the tumor niche, from the tumor core to the periphery, by magnetic resonance imaging (MRI) and spectroscopic…
View article: Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence
Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence Open
Targeting mitochondrial ion homeostasis using Kaempferol, a mitochondrial Ca2+ uniporter channel activator, improves energy metabolism and behavior soon after a traumatic brain injury (TBI) in developing rats. Because of broad TBI pathophy…
View article: Aβ-induced vulnerability propagates via the brain’s default mode network
Aβ-induced vulnerability propagates via the brain’s default mode network Open
The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission tomography ([ 18 F]florbetapir tracer for Aβ and [ 18 F]FDG tracer for glucose metab…
View article: Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain
Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain Open
Because the human brain consumes a disproportionate fraction of the resting body’s energy, positron emission tomography (PET) measurements of absolute glucose metabolism (CMR glc ) can serve as disease biomarkers. Global mean normalization…
View article: Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities
Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities Open
Imaging biomarkers are frequently proposed as endpoints for clinical trials targeting brain amyloidosis in Alzheimer's disease (AD); however, the specific impact of amyloid-β (Aβ) aggregation on biomarker abnormalities remains elusive in A…
View article: Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome
Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome Open
Significance Mice manipulated by targeted deletion of a specific brain gene show diverse pathological phenotypes, apparent, for example, in behavioral experiments. To explain observed findings, connectome genetics attempts to uncover how b…
View article: IC‐P‐099: Synergism Between Brain Amyloid Accumulation and Neuronal Injury in Cortical‐Subcortical Circuits Causes Memory Declines in Animal Models
IC‐P‐099: Synergism Between Brain Amyloid Accumulation and Neuronal Injury in Cortical‐Subcortical Circuits Causes Memory Declines in Animal Models Open
A decline in cerebrospinal fluid (CSF) Aβ1-42 is a pathological biomarker and has been reported to be inversely associated with Aβ plaque load in the brain. Also, the cerebral metabolic rate of glucose, as measured by [18F]Fluorodeoxygluco…
View article: IC‐P‐027: Amyloid‐Induced Microglial Activity in Thalamocortical Circuits Predicts Subsequent Cognitive Decline
IC‐P‐027: Amyloid‐Induced Microglial Activity in Thalamocortical Circuits Predicts Subsequent Cognitive Decline Open
Although the signature properties of Alzheimer's disease (AD), such as the formation of amyloid plaques, activation of inflammatory responses, and hyperphosphorylation have been well studied, the explanation illustrating a clear relationsh…
View article: IC‐P‐101: Synergism Between Baseline Amyloidosis and Neuronal Injury as Determinants of Learning Deficits in AD Transgenic Rat Model
IC‐P‐101: Synergism Between Baseline Amyloidosis and Neuronal Injury as Determinants of Learning Deficits in AD Transgenic Rat Model Open
The cerebral metabolic rate of glucose, as measured by [18F]Fluorodeoxyglucose ([18F]FDG) in Positron Emission Tomography (PET), is widely used as a biomarker of neurodegeneration, which has been shown to be closely related to the cognitiv…
View article: P1‐251: Synergism between Brain Amyloid Accumulation and Neuronal Injury in Cortical‐Subcortical Circuits Causes Memory Declines in Animal Models
P1‐251: Synergism between Brain Amyloid Accumulation and Neuronal Injury in Cortical‐Subcortical Circuits Causes Memory Declines in Animal Models Open
A decline in cerebrospinal fluid (CSF) Aβ1-42 is a pathological biomarker and has been reported to be inversely associated with Aβ plaque load in the brain. Also, the cerebral metabolic rate of glucose, as measured by [18F]Fluorodeoxygluco…
View article: IC‐P‐114: Pet Neuroimaging of Cholinergic Depletion in Alzheimer Disease (AD) Using [18F]‐Fluoroethoxybenzovesamicol: A Potential Biomarker.
IC‐P‐114: Pet Neuroimaging of Cholinergic Depletion in Alzheimer Disease (AD) Using [18F]‐Fluoroethoxybenzovesamicol: A Potential Biomarker. Open
The 18F-fluoroethoxybenzovesamicol (18F-FEOBV) is a PET radiotracer that binds selectively to the vesicular acetylcholine transporter (VAChT) and has been used in animals and healthy humans (Cyr et al., 2015; Parent et al., 2012; Petrou et…