Maximilian Fleischmann
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View article: Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC
Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC Open
View article: ACO/ARO/AIO-22 – External beam radiotherapy combined with endorectal high-dose-rate brachytherapy in elderly and frail patients with rectal cancer: A prospective multicentre trial of the German Rectal Cancer Study Group
ACO/ARO/AIO-22 – External beam radiotherapy combined with endorectal high-dose-rate brachytherapy in elderly and frail patients with rectal cancer: A prospective multicentre trial of the German Rectal Cancer Study Group Open
View article: Neoadjuvant chemoradiation for patients with resectable locally advanced oral cavity squamous cell carcinoma: Results of the prospective INVERT clinical trial
Neoadjuvant chemoradiation for patients with resectable locally advanced oral cavity squamous cell carcinoma: Results of the prospective INVERT clinical trial Open
Neoadjuvant CRT is feasible and safe, achieving high pCR rates in LAOCSCC.pCR was associated with improved outcomes.
View article: Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status
Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status Open
View article: Advantages of 3D printed patient-individual moulds in brachytherapy for facial skin cancer
Advantages of 3D printed patient-individual moulds in brachytherapy for facial skin cancer Open
Purpose Facial skin cancer of 42 elderly frail patients was treated with individualised 3D-printed mould applicators for high-dose-rate (HDR) brachytherapy. The dosimetric outcome was compared to conventionally manufactured individual moul…
View article: Assessment of decision-making with locally run and web-based large language models versus human board recommendations in otorhinolaryngology, head and neck surgery
Assessment of decision-making with locally run and web-based large language models versus human board recommendations in otorhinolaryngology, head and neck surgery Open
View article: ACO/ARO/AIO-22 - External Beam Radiotherapy Combined with Endorectal High-Dose-Rate Brachytherapy in Elderly and Frail Patients with Rectal Cancer: A Prospective Multicentre Trial of the German Rectal Cancer Study Group
ACO/ARO/AIO-22 - External Beam Radiotherapy Combined with Endorectal High-Dose-Rate Brachytherapy in Elderly and Frail Patients with Rectal Cancer: A Prospective Multicentre Trial of the German Rectal Cancer Study Group Open
View article: Correction to: Azacitidine in combination with shortened venetoclax treatment cycles in patients with acute myeloid leukemia
Correction to: Azacitidine in combination with shortened venetoclax treatment cycles in patients with acute myeloid leukemia Open
View article: Tumor Response and Its Impact on Treatment Failure in Rectal Cancer: Does Intensity of Neoadjuvant Treatment Matter?
Tumor Response and Its Impact on Treatment Failure in Rectal Cancer: Does Intensity of Neoadjuvant Treatment Matter? Open
Objectives: Additional adjuvant treatment in patients with rectal cancer with limited response to neoadjuvant treatment to mitigate their higher risk of treatment failure remains controversial. Methods: This is a post hoc analysis of a coh…
View article: Azacitidine in combination with shortened venetoclax treatment cycles in patients with acute myeloid leukemia
Azacitidine in combination with shortened venetoclax treatment cycles in patients with acute myeloid leukemia Open
The combination of venetoclax with hypomethylating agents is currently the standard of care for elderly patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy. Despite its favorable efficacy, clinical use is often…
View article: Persistent Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Rectal Cancer
Persistent Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Rectal Cancer Open
Importance Patients with locally advanced rectal cancer and persistent lymph node metastases (PLNM) after neoadjuvant treatment are at high risk of developing locoregional and distant metastasis, yet optimal postsurgical treatment of these…
View article: Single Center Characterization of a Cohort of Salivary Gland Carcinomas
Single Center Characterization of a Cohort of Salivary Gland Carcinomas Open
Salivary gland cancer (SGC) is a rare cancer that can present a diagnostic challenge to pathologists, with emerging, but still limited options for the treatment of recurrent/metastatic disease. We aimed to characterize the cohort of saliva…
View article: Correction: Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer
Correction: Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer Open
View article: MRI-based radiomics for predicting histology in malignant salivary gland tumors: methodology and “proof of principle”
MRI-based radiomics for predicting histology in malignant salivary gland tumors: methodology and “proof of principle” Open
Defining the exact histological features of salivary gland malignancies before treatment remains an unsolved problem that compromises the ability to tailor further therapeutic steps individually. Radiomics, a new methodology to extract qua…
View article: Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma
Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma Open
Anal squamous cell carcinoma (ASCC) is associated with immunosuppression and infection with human papillomavirus (HPV). Response to standard chemoradiotherapy (CRT) varies considerably. A comprehensive molecular characterization of CRT res…
View article: Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer
Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer Open
View article: Synergistic Effects of the RARalpha Agonist Tamibarotene and the Menin Inhibitor Revumenib in Acute Myeloid Leukemia Cells with KMT2A Rearrangement or NPM1 Mutation
Synergistic Effects of the RARalpha Agonist Tamibarotene and the Menin Inhibitor Revumenib in Acute Myeloid Leukemia Cells with KMT2A Rearrangement or NPM1 Mutation Open
Inhibition of menin in acute myeloid leukemia (AML) harboring histone-lysine-N-methyltransferase 2A rearrangement (KMT2Ar) or the mutated Nucleophosmin gene (NPM1c) is considered a novel and effective treatment approach in these patients. …
View article: Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial
Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial Open
Our analyses imply that alterations of the innate immune cell distribution in the peripheral blood following induction chemo-immuno-therapy is highly predictive for pCR in HNSCC.
View article: Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial
Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial Open
Raw cell counts from peripheral blood immune phenotyping across individual patients.
View article: Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial
Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial Open
<p>Raw cell counts from peripheral blood immune phenotyping across individual patients.</p>
View article: Overall Survival After Treatment Failure Among Patients With Rectal Cancer
Overall Survival After Treatment Failure Among Patients With Rectal Cancer Open
Importance Oncologic outcomes among patients with rectal cancer after developing local recurrence and/or distant metastases remain poorly studied. Objective To analyze the trend of overall survival after treatment failure for patients with…
View article: 944TiP Randomized phase II study of immune stimulation with pembrolizumab and radiotherapy of recurrent and/or metastatic head and neck squamous cell carcinoma : The IMPORTANCE trial
944TiP Randomized phase II study of immune stimulation with pembrolizumab and radiotherapy of recurrent and/or metastatic head and neck squamous cell carcinoma : The IMPORTANCE trial Open
View article: Vergleich der radikalen Zystektomie mit der trimodalen Therapie beim muskelinvasiven Harnblasenkarzinom
Vergleich der radikalen Zystektomie mit der trimodalen Therapie beim muskelinvasiven Harnblasenkarzinom Open
View article: P474: FUNCTIONAL (PHOSPHO-)PROTEOMICS OF DRUG RESPONSE IN ACUTE MYELOID LEUKEMIA
P474: FUNCTIONAL (PHOSPHO-)PROTEOMICS OF DRUG RESPONSE IN ACUTE MYELOID LEUKEMIA Open
Background: Acute Myeloid Leukemia (AML) is a particularly heterogeneous malignancy, for which standard care often fails to reach a durable response. Given the high inter-individual diversity, patients could potentially benefit from therap…
View article: PB1774: PHARMACOLOGICAL STRATEGIES TO OVERCOME RESISTANCE IN AML CELL LINE MODELS HARBORING ACTIVATING FLT3-ITD AND PTPN11 MUTATIONS
PB1774: PHARMACOLOGICAL STRATEGIES TO OVERCOME RESISTANCE IN AML CELL LINE MODELS HARBORING ACTIVATING FLT3-ITD AND PTPN11 MUTATIONS Open
Topic: 3. Acute myeloid leukemia - Biology & Translational Research Background: Primary or secondary resistance towards various AML-treatment strategies like intensive chemotherapy, tyrosine kinase inhibitors or combination of the BCL-2 in…
View article: Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy
Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy Open
View article: Customized 3D‐printed molds for high dose‐rate brachytherapy in facial skin cancer: First clinical experience
Customized 3D‐printed molds for high dose‐rate brachytherapy in facial skin cancer: First clinical experience Open
Summary Background and Objective Radiotherapy of elderly, frail patients with facial skin cancer in proximity to critical organs is challenging. This is the first report on clinical experience with facial skin cancer treated by individuali…
View article: 3D‐gedruckte Moulagen für die individualisierte HDR‐Brachytherapie kutaner Malignome im Gesichtsbereich: Erste klinische Erfahrungen
3D‐gedruckte Moulagen für die individualisierte HDR‐Brachytherapie kutaner Malignome im Gesichtsbereich: Erste klinische Erfahrungen Open
Zusammenfassung Hintergrund und Zielsetzung Die Strahlentherapie älterer sowie gebrechlicher Patienten mit kutanen Malignomen im Gesichtsbereich kann eine klinische Herausforderung darstellen. Dies ist der erste Bericht über die klinischen…
View article: Prognostic Impact of Caspase-8, CDK9 and Phospho-CDK9 (Thr 186) Expression in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiation and Brachytherapy
Prognostic Impact of Caspase-8, CDK9 and Phospho-CDK9 (Thr 186) Expression in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiation and Brachytherapy Open
Introduction: After primary platinum-based chemoradiation of locally advanced uterine cervical cancer, a substantial proportion of women present with persistent, recurrent or metastatic disease, indicating an unmet need for biomarker devel…
View article: Development and Validation of a Predictive Model for Toxicity of Neoadjuvant Chemoradiotherapy in Rectal Cancer in the CAO/ARO/AIO-04 Phase III Trial
Development and Validation of a Predictive Model for Toxicity of Neoadjuvant Chemoradiotherapy in Rectal Cancer in the CAO/ARO/AIO-04 Phase III Trial Open
Background: There is a lack of predictive models to identify patients at risk of high neoadjuvant chemoradiotherapy (CRT)-related acute toxicity in rectal cancer. Patient and Methods: The CAO/ARO/AIO-04 trial was divided into a development…