Maximilian Leitheiser
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View article: DNA Methylation Profiling of Salivary Gland Tumors Supports and Expands Conventional Classification
DNA Methylation Profiling of Salivary Gland Tumors Supports and Expands Conventional Classification Open
Tumors of the major and minor salivary glands histologically encompass a diverse and partly overlapping spectrum of frequent diagnostically challenging neoplasms. Despite recent advances in molecular testing and the identification of tumor…
View article: Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas
Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas Open
The diagnosis of ependymoma has moved from a purely histopathological review with limited prognostic value to an integrated diagnosis, relying heavily on molecular information. However, as the integrated approach is still novel and some mo…
View article: DNA methylation-based classification of sinonasal tumors
DNA methylation-based classification of sinonasal tumors Open
The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SNUCs). In this study, we apply …
View article: Machine learning models predict the primary sites of head and neck squamous cell carcinoma metastases based on <scp>DNA</scp> methylation
Machine learning models predict the primary sites of head and neck squamous cell carcinoma metastases based on <span>DNA</span> methylation Open
In head and neck squamous cell cancers (HNSCs) that present as metastases with an unknown primary (HNSC‐CUPs), the identification of a primary tumor improves therapy options and increases patient survival. However, the currently available …
View article: PEDIA: Prioritization of Exome Data by Image Analysis
PEDIA: Prioritization of Exome Data by Image Analysis Open
Phenotype information is crucial for the interpretation of genomic variants. So far it has only been accessible for bioinformatics workflows after encoding into clinical terms by expert dysmorphologists. Here, we introduce an approach, dri…