Maximilian Reichert
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View article: Development of a translational radiobiology platform using pancreatic cancer patient-derived organoids for personalized radiation oncology
Development of a translational radiobiology platform using pancreatic cancer patient-derived organoids for personalized radiation oncology Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with neoadjuvant radio(chemo)therapy failing in approximately 70 % of cases due to high tumor heterogeneity, and intrinsic radioresistance. Patient-derived …
View article: Navigating rare cancer care: Patient-reported insights into patient journeys, time to diagnosis, decision-making and care coordination from a national cross-sectional study in Germany
Navigating rare cancer care: Patient-reported insights into patient journeys, time to diagnosis, decision-making and care coordination from a national cross-sectional study in Germany Open
Patients with RC in Germany experience longer diagnostic pathways and fragmented care, highlighting the need for targeted, cross-sectoral care coordination and greater patient empowerment.
View article: Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time
Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time Open
Resistance to chemotherapy of pancreatic ductal adenocarcinoma (PDAC) is largely driven by intratumoral heterogeneity (ITH) due to tumor cell plasticity and clonal diversity. To develop alternative strategies to overcome this defined mecha…
View article: Instrument design and performance of the first seven stations of RNO-G
Instrument design and performance of the first seven stations of RNO-G Open
The Radio Neutrino Observatory in Greenland (RNO-G) is the first in-ice radio array in the northern hemisphere for the detection of ultra-high energy neutrinos via the coherent radio emission from neutrino-induced particle cascades within …
View article: Accelerated maturation of branched organoids confined in collagen droplets
Accelerated maturation of branched organoids confined in collagen droplets Open
Droplet-based organoid culture offers several advantages over conventional bulk organoid culture, such as improved yield, reproducibility, and throughput. However, organoids grown in droplets typically display only a spherical geometry and…
View article: A floating collagen matrix triggers ring formation and stemness characteristics in human colorectal cancer organoids
A floating collagen matrix triggers ring formation and stemness characteristics in human colorectal cancer organoids Open
Intestinal organoids reflect the 3D structure and function of their original tissues. Organoid are typically cultured in Matrigel, an extracellular matrix (ECM) mimicking the basement membrane, which is suitable for epithelial cells but do…
View article: A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development Open
View article: Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy Open
View article: c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation
c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation Open
Pancreatic ductal adenocarcinoma remains one of the deadliest malignancies, with limited treatment options and a high recurrence rate. Recurrence happens often with metastasis, for which cancer cells must adapt to isolation stress to succe…
View article: Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response
Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response Open
The DNA-damaging agent Gemcitabine (GEM) is a first-line treatment for pancreatic cancer, but chemoresistance is frequently observed. Several clinical trials investigate the efficacy of GEM in combination with targeted drugs, including kin…
View article: TROPHIT1—a randomized, open-label, multicenter, phase II/III trial of sacituzumab govitecan compared to standard of care in metastatic colorectal cancer patients
TROPHIT1—a randomized, open-label, multicenter, phase II/III trial of sacituzumab govitecan compared to standard of care in metastatic colorectal cancer patients Open
Background: Colorectal cancer (CRC) ranks among the most common malignancies worldwide. Response rates to standard-of-care (SOC) treatment drop sharply beyond the second treatment line. Trophoblast cell surface antigen-2 (TROP2) acts in a …
View article: Accelerated maturation of branched organoids confined in collagen droplets
Accelerated maturation of branched organoids confined in collagen droplets Open
Droplet microfluidics enables the formation of branched PDAC organoids in collagen droplets. Morphological and transcriptomic data reveal accelerated maturation compared to bulk cultures.
View article: PKMYT1 Inhibition Enhances Radiosensitivity in Pancreatic Ductal Adenocarcinoma
PKMYT1 Inhibition Enhances Radiosensitivity in Pancreatic Ductal Adenocarcinoma Open
View article: A 3D patternoid model for the reproducible characterization of invasive phenotypes and drug sensitivity in PDAC
A 3D patternoid model for the reproducible characterization of invasive phenotypes and drug sensitivity in PDAC Open
A reproducible 3D patternoid platform enabling high-throughput analysis of PDAC invasion dynamics and drug sensitivities with biomimetic microcavities.
View article: Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma Open
In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural heterogeneity increases chemoresistance and mortality rates. However, such morphological and phenotypic diversities are not typically captured by org…
View article: Engineering de novo binder CAR-T cell therapies with generative AI
Engineering de novo binder CAR-T cell therapies with generative AI Open
Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized cancer treatment, with six CAR-T products currently in clinical use 1–4 . Despite their success, high resistance rates due to antigen escape remain a major challenge 5,…
View article: Instrument design and performance of the first seven stations of RNO-G
Instrument design and performance of the first seven stations of RNO-G Open
The Radio Neutrino Observatory in Greenland (RNO-G) is the first in-ice radio array in the northern hemisphere for the detection of ultra-high energy neutrinos via the coherent radio emission from neutrino-induced particle cascades within …
View article: Trametinib in combination with hydroxychloroquine or palbociclib in advanced metastatic pancreatic cancer: data from a retrospective, multicentric cohort (AIO AIO-TF/PAK-0123)
Trametinib in combination with hydroxychloroquine or palbociclib in advanced metastatic pancreatic cancer: data from a retrospective, multicentric cohort (AIO AIO-TF/PAK-0123) Open
Background Preclinical models of pancreatic cancer (PDAC) suggest a synergistic role for combined MEK and autophagy signaling inhibition, as well as MEK and CDK4/6 pathway targeting. Several case reports implicate clinical activity of the …
View article: <scp>KRAS<sup>G</sup></scp><sup>12<scp>C</scp></sup>‐inhibitor‐based combination therapies for pancreatic cancer: insights from drug screening
<span>KRAS<sup>G</sup></span><sup>12<span>C</span></sup>‐inhibitor‐based combination therapies for pancreatic cancer: insights from drug screening Open
Pancreatic ductal adenocarcinoma (PDAC) has limited treatment options, emphasizing the urgent need for effective therapies. The predominant driver in PDAC is mutated KRAS proto‐oncogene, KRA , present in 90% of patients. The emergence of d…
View article: Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids
Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids Open
View article: A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction
A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction Open
Cancer cells must develop strategies to adapt to the dynamically changing stresses caused by intrinsic or extrinsic processes, or therapeutic agents. Metabolic adaptability is crucial to mitigate such challenges. Considering metabolism as …
View article: Corrigendum to “A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer” [Bioorgan. Chem. 119 (2022) 105505]
Corrigendum to “A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer” [Bioorgan. Chem. 119 (2022) 105505] Open
View article: Comparison of endoscopic ultrasound-guided fine-needle aspiration and fine-needle biopsy to generate pancreatic cancer organoids: Randomized trial
Comparison of endoscopic ultrasound-guided fine-needle aspiration and fine-needle biopsy to generate pancreatic cancer organoids: Randomized trial Open
Background and study aims The prognosis for pancreatic cancer remains poor. Molecular diagnostics and customized therapies are becoming increasingly important in clinical routine. Patient-derived, predictive model systems such as organoids…
View article: Implementation of Modern Radiotherapy in a Multimodal Approach for Locally Advanced Pancreatic Cancer
Implementation of Modern Radiotherapy in a Multimodal Approach for Locally Advanced Pancreatic Cancer Open
View article: Heisenberg-Limited Quantum Lidar for Joint Range and Velocity Estimation
Heisenberg-Limited Quantum Lidar for Joint Range and Velocity Estimation Open
We propose a quantum lidar protocol to jointly estimate the range and velocity of a target by illuminating it with a single beam of pulsed displaced squeezed light. In the lossless scenario, we show that the mean-squared errors of both ran…
View article: Lenvatinib plus Pembrolizumab as first-line treatment in patients with advanced renal cell carcinoma – real world data from a retrospective multi-center analysis
Lenvatinib plus Pembrolizumab as first-line treatment in patients with advanced renal cell carcinoma – real world data from a retrospective multi-center analysis Open
View article: An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies
An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies Open
Our results suggest that PDAC characterized by SMAD4 deficiency and oncogenic NFATc1/SMAD3/cJUN complex formation exposes sensitivity to a mitogen-activated protein kinase signaling inhibition and gemcitabine combination therapy.
View article: Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion
Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion Open
Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled i…
View article: In-vitro model to mimic T cell subset change in human PDAC organoid co-culture
In-vitro model to mimic T cell subset change in human PDAC organoid co-culture Open
View article: Fulminant Liver Failure after Treatment with a Checkpoint Inhibitor for Gastric Cancer: A Case Report and Review of the Literature
Fulminant Liver Failure after Treatment with a Checkpoint Inhibitor for Gastric Cancer: A Case Report and Review of the Literature Open
Nivolumab is a promising monoclonal antibody inhibitor of programmed death-1, a protein on the surface of T-cells. As such, it is approved for use in patients with multiple advanced malignancies and can significantly elongate progression-f…